Однос триглицерида и липопротеина холестерола велике густине повишен је код пацијената са компликованим дијабетесом мелитусом типа 2
ТХР код ДМ типа 2 са хроничним компликацијама
Sažetak
Microvascular and macrovascular complications lead to recurrent hospital admissions, hospitalizations, disability and death in the course of type 2 diabetes mellitus (T2DM). Triglyceride to HDL cholesterol ratio (THR) is associated with insulin resistance. We aimed to find out whether there is a relationship between THR and diabetic complications in patients with T2DM.
Patients with T2DM were enrolled to the study. Study population grouped into two according to the presence or absence of diabetic complications. Characteristics and laboratory data of the patients with (group A) and without (group B) diabetic complications were compared.
Median THR values of the groups A and B were 3.86 (0.33-53.38) and 2.86 (0.63-17.88), respectively (p=0.006). THR level was significantly and positively correlated with HbA1c (r=0.12, p=0.04) and fasting glucose levels (r=0.14, p=0.02).
We suggest that THR should be monitored in patients with type 2 diabetes mellitus in order to detect diabetic microvascular complications earlier. Increased THR levels should prompt further investigation of diabetic complications in this population.
Reference
1. Deshpande AD, Harris-Hayes M, Schootman M. Epidemiology of diabetes and diabetes-related complications. Physical therapy. 2008;88(11):1254-64.
2. Hayfron-Benjamin C, van den Born B-J, Maitland-van der Zee AH, Amoah AG, Meeks KA, Klipstein-Grobusch K, et al. Microvascular and macrovascular complications in type 2 diabetes Ghanaian residents in Ghana and Europe: The RODAM study. Journal of Diabetes and its Complications. 2019;33(8):572-8.
3. Kalofoutis C, Piperi C, Kalofoutis A, Harris F, Phoenix D, Singh J. Type II diabetes mellitus and cardiovascular risk factors: current therapeutic approaches. Experimental & Clinical Cardiology. 2007;12(1):17.
4. Fuller J, Stevens L, Wang S. Risk factors for cardiovascular mortality and morbidity: The WHO multinational study of vascular disease in diabetes. Diabetologia. 2001;44(2):S54-S64.
5. Chawla A, Chawla R, Jaggi S. Microvasular and macrovascular complications in diabetes mellitus: distinct or continuum? Indian journal of endocrinology and metabolism. 2016;20(4):546.
6. Almdal T, Scharling H, Jensen JS, Vestergaard H. The independent effect of type 2 diabetes mellitus on ischemic heart disease, stroke, and death: a population-based study of 13 000 men and women with 20 years of follow-up. Archives of internal medicine. 2004;164(13):1422-6.
7. Chahil TJ, Ginsberg HN. Diabetic dyslipidemia. Endocrinology and Metabolism Clinics. 2006;35(3):491-510.
8. Ginsberg HN, Bonds DE, Lovato LC, Crouse JR, Elam MB, Linz PE, et al. Evolution of the lipid trial protocol of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial. The American journal of cardiology. 2007;99(12):S56-S67.
9. McLaughlin T, Abbasi F, Cheal K, Chu J, Lamendola C, Reaven G. Use of metabolic markers to identify overweight individuals who are insulin resistant. Annals of internal medicine. 2003;139(10):802-9.
10. Kim-Dorner S-J, Deuster PA, Zeno SA, Remaley AT, Poth M. Should triglycerides and the triglycerides to high-density lipoprotein cholesterol ratio be used as surrogates for insulin resistance? Metabolism. 2010;59(2):299-304.
11. He S, Wang S, Chen X, Jiang L, Peng Y, Li L, et al. Higher ratio of triglyceride to high-density lipoprotein cholesterol may predispose to diabetes mellitus: 15-year prospective study in a general population. Metabolism. 2012;61(1):30-6.
12. Kocak MZ, Aktas G, Duman TT, Atak BM, Kurtkulagi O, Tekce H, et al. Monocyte lymphocyte ratio As a predictor of Diabetic Kidney Injury in type 2 Diabetes mellitus; The MADKID Study. Journal of Diabetes & Metabolic Disorders. 2020:1-6.
13. Atak BM, Duman TT, Aktas G, Kocak MZ, Savli H. Platelet distribution width is associated with type 2 diabetes mellitus and diabetic nephropathy and neuropathy. National J Health Sci. 2018;3(3):95-8.
14. Kocak MZ, Aktas G, Duman TT, Atak BM, Savli H. Is Uric Acid elevation a random finding or a causative agent of diabetic nephropathy? Revista da Associação Médica Brasileira. 2019;65(9):1155-60.
15. Aktas G, Kocak MZ, Bilgin S, Atak BM, Duman TT, Kurtkulagi O. Uric acid to HDL cholesterol ratio is a strong predictor of diabetic control in men with type 2 diabetes mellitus. The Aging Male. 2020;23(5): 1098-1102.
16. Kocak MZ, Aktas G, Atak BM, Duman TT, Yis OM, Erkus E, et al. Is Neuregulin‐4 a predictive marker of microvascular complications in type 2 diabetes mellitus? European journal of clinical investigation. 2020;50(3):e13206.
17. Tekce BK, Tekce H, Aktas G, Sit M. Evaluation of the urinary kidney injury molecule-1 levels in patients with diabetic nephropathy. Clinical and Investigative Medicine. 2014:E377-E83.
18. Tekce H, Tekce BK, Aktas G, Alcelik A, Sengul E. Serum omentin-1 levels in diabetic and nondiabetic patients with chronic kidney disease. Experimental and Clinical Endocrinology & Diabetes. 2014;122(08):451-6.
19. Anderson JL, Bakker SJ, Tietge UJ. Triglyceride/HDL cholesterol ratio and premature all-cause mortality in renal transplant recipients. Nephrology Dialysis Transplantation. 2020.
20. Anderson JL, Bakker SJ, Tietge UJ. The triglyceride to HDL-cholesterol ratio and chronic graft failure in renal transplantation. Journal of Clinical Lipidology. 2021.
21. Xia W, Yao X, Chen Y, Lin J, Vielhauer V, Hu H. Elevated TG/HDL-C and non-HDL-C/HDL-C ratios predict mortality in peritoneal dialysis patients. BMC nephrology. 2020;21(1):1-9.
22. Olabode OP, Akinlade OM, Babatunde AS, Abdulazeez MI, Biliaminu SA, Oyabambi AO, et al. Triglyceride/HDL-cholesterol ratio and plasminogen activator inhibitor-1 independently predict high pulse pressure in sickle cell trait and disease. Archives of physiology and biochemistry. 2020;126(2):166-71.
23. Engin M, Güvenç O, editors. Investigation of the predictive values of triglyceride/HDL cholesterol ratio and whole blood viscosity with regard to severe peripheral or carotid artery disease in patients scheduled for coronary bypass. Heart Surg Forum; 2020.
24. Woo M-H, Lee KO, Chung D, Choi J-W, Kim S-H, Oh S-H. Triglyceride/HDL-Cholesterol Ratio as an Index of Intracranial Atherosclerosis in Nonstroke Individuals. Frontiers in Neurology. 2021;11:1822.
2. Hayfron-Benjamin C, van den Born B-J, Maitland-van der Zee AH, Amoah AG, Meeks KA, Klipstein-Grobusch K, et al. Microvascular and macrovascular complications in type 2 diabetes Ghanaian residents in Ghana and Europe: The RODAM study. Journal of Diabetes and its Complications. 2019;33(8):572-8.
3. Kalofoutis C, Piperi C, Kalofoutis A, Harris F, Phoenix D, Singh J. Type II diabetes mellitus and cardiovascular risk factors: current therapeutic approaches. Experimental & Clinical Cardiology. 2007;12(1):17.
4. Fuller J, Stevens L, Wang S. Risk factors for cardiovascular mortality and morbidity: The WHO multinational study of vascular disease in diabetes. Diabetologia. 2001;44(2):S54-S64.
5. Chawla A, Chawla R, Jaggi S. Microvasular and macrovascular complications in diabetes mellitus: distinct or continuum? Indian journal of endocrinology and metabolism. 2016;20(4):546.
6. Almdal T, Scharling H, Jensen JS, Vestergaard H. The independent effect of type 2 diabetes mellitus on ischemic heart disease, stroke, and death: a population-based study of 13 000 men and women with 20 years of follow-up. Archives of internal medicine. 2004;164(13):1422-6.
7. Chahil TJ, Ginsberg HN. Diabetic dyslipidemia. Endocrinology and Metabolism Clinics. 2006;35(3):491-510.
8. Ginsberg HN, Bonds DE, Lovato LC, Crouse JR, Elam MB, Linz PE, et al. Evolution of the lipid trial protocol of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial. The American journal of cardiology. 2007;99(12):S56-S67.
9. McLaughlin T, Abbasi F, Cheal K, Chu J, Lamendola C, Reaven G. Use of metabolic markers to identify overweight individuals who are insulin resistant. Annals of internal medicine. 2003;139(10):802-9.
10. Kim-Dorner S-J, Deuster PA, Zeno SA, Remaley AT, Poth M. Should triglycerides and the triglycerides to high-density lipoprotein cholesterol ratio be used as surrogates for insulin resistance? Metabolism. 2010;59(2):299-304.
11. He S, Wang S, Chen X, Jiang L, Peng Y, Li L, et al. Higher ratio of triglyceride to high-density lipoprotein cholesterol may predispose to diabetes mellitus: 15-year prospective study in a general population. Metabolism. 2012;61(1):30-6.
12. Kocak MZ, Aktas G, Duman TT, Atak BM, Kurtkulagi O, Tekce H, et al. Monocyte lymphocyte ratio As a predictor of Diabetic Kidney Injury in type 2 Diabetes mellitus; The MADKID Study. Journal of Diabetes & Metabolic Disorders. 2020:1-6.
13. Atak BM, Duman TT, Aktas G, Kocak MZ, Savli H. Platelet distribution width is associated with type 2 diabetes mellitus and diabetic nephropathy and neuropathy. National J Health Sci. 2018;3(3):95-8.
14. Kocak MZ, Aktas G, Duman TT, Atak BM, Savli H. Is Uric Acid elevation a random finding or a causative agent of diabetic nephropathy? Revista da Associação Médica Brasileira. 2019;65(9):1155-60.
15. Aktas G, Kocak MZ, Bilgin S, Atak BM, Duman TT, Kurtkulagi O. Uric acid to HDL cholesterol ratio is a strong predictor of diabetic control in men with type 2 diabetes mellitus. The Aging Male. 2020;23(5): 1098-1102.
16. Kocak MZ, Aktas G, Atak BM, Duman TT, Yis OM, Erkus E, et al. Is Neuregulin‐4 a predictive marker of microvascular complications in type 2 diabetes mellitus? European journal of clinical investigation. 2020;50(3):e13206.
17. Tekce BK, Tekce H, Aktas G, Sit M. Evaluation of the urinary kidney injury molecule-1 levels in patients with diabetic nephropathy. Clinical and Investigative Medicine. 2014:E377-E83.
18. Tekce H, Tekce BK, Aktas G, Alcelik A, Sengul E. Serum omentin-1 levels in diabetic and nondiabetic patients with chronic kidney disease. Experimental and Clinical Endocrinology & Diabetes. 2014;122(08):451-6.
19. Anderson JL, Bakker SJ, Tietge UJ. Triglyceride/HDL cholesterol ratio and premature all-cause mortality in renal transplant recipients. Nephrology Dialysis Transplantation. 2020.
20. Anderson JL, Bakker SJ, Tietge UJ. The triglyceride to HDL-cholesterol ratio and chronic graft failure in renal transplantation. Journal of Clinical Lipidology. 2021.
21. Xia W, Yao X, Chen Y, Lin J, Vielhauer V, Hu H. Elevated TG/HDL-C and non-HDL-C/HDL-C ratios predict mortality in peritoneal dialysis patients. BMC nephrology. 2020;21(1):1-9.
22. Olabode OP, Akinlade OM, Babatunde AS, Abdulazeez MI, Biliaminu SA, Oyabambi AO, et al. Triglyceride/HDL-cholesterol ratio and plasminogen activator inhibitor-1 independently predict high pulse pressure in sickle cell trait and disease. Archives of physiology and biochemistry. 2020;126(2):166-71.
23. Engin M, Güvenç O, editors. Investigation of the predictive values of triglyceride/HDL cholesterol ratio and whole blood viscosity with regard to severe peripheral or carotid artery disease in patients scheduled for coronary bypass. Heart Surg Forum; 2020.
24. Woo M-H, Lee KO, Chung D, Choi J-W, Kim S-H, Oh S-H. Triglyceride/HDL-Cholesterol Ratio as an Index of Intracranial Atherosclerosis in Nonstroke Individuals. Frontiers in Neurology. 2021;11:1822.
Objavljeno
2025/12/19
Broj časopisa
Rubrika
Originalni rad / Original article