Evaluacija kliničkih i biohemijskih parametara hospitaliziranih COVID-19 pacijenata -retrospektivna studija iz Bosne i Hercegovine

Sažetak

For the first time, to evaluate and present the socio-demographic and clinical manifestations, laboratory findings, and outcomes of hospitalized Coronavirus Disease 2019 (COVID-19) patients from Canton Sarajevo, Bosnia and Herzegovina. This retrospective, single-centre study included 159 RT-PCR verified COVID-19 patients (92 mild/moderate and 67 severe/critical) consecutively hospitalized at the General Hospital "Prim. dr Abdulah Nakaš" in Sarajevo, Bosnia and Herzegovina. Socio-demographic, clinical, and laboratory data on admission were retrospectively obtained from each patient's electronic medical record and patient files by two experienced physicians.

The study was conducted from November 1st, 2020 to March 15th, 2021. Most of the patients (43.4%) belonged to the age range of 46 - 65 years; 71.1% were men, and 68.6% had comorbidities. Among the patients who had comorbidities, hypertension was the most prevalent comorbidity (100%), followed by diabetes (91.7%), and ischemic heart disease (35.8%). The leading clinical symptoms were fever (87.44%), tiredness (77.8%), and body/muscle aches (73%). There was significant reduction of blood oxygen saturation (p=0.005), and significant elevation of D-dimer (p=0.003), CRP (p=0.044), and fasting plasma glucose (p=0.047) in the severe/critical patients group compared to mild/moderate group.

Older age, the male gender, confirmed comorbidities, decreased blood oxygen saturation, increased levels of CRP, D-dimer, and fasting plasma glucose, together with symptoms of chest pain/shortness of breath and/or diarrhea occurred more frequently in severe/critical than mild/moderate COVID-19 and contributed to adverse outcomes.