Ефекат оралне конзумације екстракта лаванде (Лавандула) на пред-хипертензију код пензионера пензионих центара: насумично клиничко испитивање
Oral Consumption of Lavender Extract on pre-hypertension
Sažetak
Hypertension is a common disorder of old age, which could be prevented by medicinal herbs. The present study aimed to evaluate the effect of lavender extract on pre-hypertension in the retired population.
This triple-blind clinical trial was conducted on 60 retired men and women who were divided into two groups of lavender extract and placebo using the permuted block technique. Lavender extract and placebo were used twice a day (3 cc each time) for two weeks. Blood pressure was measured before use, in the first and second week after use, and one week after the discontinuation of the medication to evaluate the stability of the drug effects. Data analysis was performed in STATA software version 14 at the significance level of P<0.05.
Before the intervention, the mean systolic blood pressure in the lavender extract and placebo groups was 133.9±9.3 and 127.3±6.3 mmHg, respectively. After the one-week intervention, the mean blood pressure of the groups was respectively 123.1±12.6 and 125.8±7.2, while it was 120.8±10.7 and 127.9±2 after two weeks. One week after drug discontinuation, these levels were estimated at 123.7±10.7 and 129.2±10.10, respectively. The results of repeated measures ANOVA indicated that lavender extract had significant effects on systolic and diastolic blood pressure in the intervention group (P<0.05).
According to the results, lavender extract was effective in pre-hypertension control in the retired subjects.
Reference
References
1. Barimani A, Donyavi R, Taghizade S. The Effectiveness of Positive Psychotherapy on Optimism and Alexithymia in Retired Female Teachers with Anxiety. Positive Psychology Research. 2020;6(2):49-64. Available from:
https://ppls.ui.ac.ir/article_25272.html?lang=en
2. Tajvar M, Arab M, Montazeri A. Determinants of health-related quality of life in elderly in Tehran, Iran. BMC public health. 2008 Dec;8(1):1-8. https://doi.org/10.1186/1471-2458-8-323
3. Hedayati B. Effect of Family-Based Empowerment Model on the Self-Efficacy of Hypertensive Elderly People. Iranian Journal of Ageing. 2018 Apr 10;13(1):86-97 . URL: http://salmandj.uswr.ac.ir/article-1-1281-en.html
4. Ursua RA, Aguilar DE, Wyatt LC, Trinh-Shevrin C, Gamboa L, Valdellon P, Perrella EG, Dimaporo MZ, Nur PQ, Tandon SD, Islam NS. A community health worker intervention to improve blood pressure among Filipino Americans with hypertension: A randomized controlled trial. Preventive medicine reports. 2018 Sep 1;11:42-8.
https://doi.org/10.1016/j.pmedr.2018.05.002
5. Chiang CE, Wang TD, Lin TH, Yeh HI, Liu PY, Cheng HM, etal. The 2017 Focused Update of the Guidelines of the Taiwan Society of Cardiology (TSOC) and the Taiwan Hypertension Society (THS) for the Management of Hypertension. Acta Cardiol Sin. 2017 May;33(3):213-225. doi: 10.6515/acs20170421a. PMID: 28559651; PMCID: PMC5445238.
6. Mahmoodabad SSM, et al. The Rate of Compliance of Prehypertension Individuals from Dietary Approaches to Stop Hypertension (DASH): An Application of the Theory of Planned Behavior. Ann Med Health Sci Res. 2019;9:448-452 Available from: https://www.amhsr.org/articles/the-rate-of-compliance-of-prehypertension-individuals-from-dietary-approaches-to-stop-hypertension-dash-an-application-o.pdf
7. Nerenberg KA, Zarnke KB, Leung AA, Dasgupta K, Butalia S, McBrien K, Harris KC, Nakhla M, Cloutier L, Gelfer M, Lamarre-Cliche M. Hypertension Canada’s 2018 guidelines for diagnosis, risk assessment, prevention, and treatment of hypertension in adults and children. Canadian Journal of Cardiology. 2018 May 1;34(5):506-25. https://doi.org/10.1016/j.cjca.2018.02.022
8. Kanamori S, Takamiya T, Inoue S. Group exercise for adults and elderly: Determinants of participation in group exercise and its associations with health outcome. The Journal of Physical Fitness and Sports Medicine. 2015 Sep 25;4(4):315-20. https://doi.org/10.7600/jpfsm.4.315
9. Ataie Z, Allahverdi A, Dehnoalian A, Orooji A. The relationship between lifestyle and general health among elderly people in Neyshabur. Iran Journal of Nursing. 2018;31(111):10-19. Available from: http://eprints.nums.ac.ir/333/1/%D8%AF%D9%87%D9%86%D9%88%D8%B9%D9%84%DB%8C%D8%A7%D9%86-%20%D8%A7%D8%B1%D8%AA%D8%A8%D8%A7%D8%B7%20%D8%B3%D8%A8%DA%A9%20%D8%B2%D9%86%D8%AF%DA%AF%DB%8C.pdf
10. Cheraghi P, Eskandari Z, Bozorgmehr S, Zanjari N, Cheraghi Z. Quality of Life and its Related Factors among Elderly People. J Educ Community Health. 2019 Jul 10;6(3):145-51. Available from: http://jech.umsha.ac.ir/article-1-620-en.html
11. Momen Abadi S, Sameni H, Zahedi Khorasani M, Vakili A. Evaluation the Nutritional Effect of Lavandula angustifolia L. Essential Oil on Normal and High Blood Pressure and Changes of the Aorta in the Rat. J. Med. Plants. 2015; 14 (56) :55-63
Available from: http://jmp.ir/article-1-1225-fa.html
12. Alizadeh A, Aghaee Z. Essential oil constituents, phenolic content and antioxidant activity of Lavandula stricta Delile growing wild in southern Iran. Natural product research. 2016 Oct 1;30(19):2253-7. https://doi.org/10.1080/14786419.2016.1155578
13. Firoozeei TS, Barekatain M, Karimi M, Zargaran A, Akhondzadeh S, Rezaeizadeh H. Lavender and dodder combined herbal syrup versus citalopram in major depressive disorder with anxious distress: A double-blind randomized trial. Journal of Integrative Medicine. 2020 Sep 1;18(5):409-15.
https://doi.org/10.1016/j.joim.2020.06.002
14. Sharma Y, Jeyabalan G, Singh R. Potential wound healing agents from medicinal plants: a review. Pharmacologia. 2013;4(5):349-58. doi : 10.5567/pharmacologia.2013.349.358
15. Nugraha A, Widyawaty E, Hernanto F, Indrianita V, Kristianto H. effect of nutmeg and lavender essential oil on blood pressure in the elderly with hypertension. PalArch's Journal of Archaeology of Egypt/Egyptology. 2020 Dec 1;17(6):10076-83. https://archives.palarch.nl/index.php/jae/article/view/2570
16. Gilani A, Aziz N, Khan M, Shaheen F, Jabeen Q, Siddiqui B, et al. Ethnopharmacological evaluation of the anticonvulsant, sedative and antispasmodic activities of Lavandula stoechas L. Journal of Ethnopharmacology. 2000;71(1-2):161-7. https://doi.org/10.1016/S0378-8741(99)00198-1
17. Lytle J, Mwatha C, Davis KK. Effect of lavender aromatherapy on vital signs and perceived quality of sleep in the intermediate care unit: a pilot study. American journal of critical care. 2014 Jan;23(1):24-9. https://doi.org/10.4037/ajcc2014958
18. Maisi S, Suryono S, Widyawati MN, Suwondo A, Kusworowulan S. Effectiveness of lavender aromatherapy and classical music therapy in lowering blood pressure in pregnant women with hypertension. Belitung Nursing Journal. 2017 Dec 28;3(6):750-6. https://doi.org/10.33546/bnj.301
19. Ahmad R, Naqvi AA, Al-Bukhaytan HM, Al-Nasser AH, Al-Ebrahim AH. Evaluation of aromatherapy with lavender oil on academic stress: a randomized placebo controlled clinical trial. Contemporary clinical trials communications. 2019 Jun 1;14:100346. https://doi.org/10.1016/j.conctc.2019.100346
20. Salamati A, Mashouf S, Mojab F. Effect of Inhalation of Lavender Essential Oil on Vital Signs in Open Heart Surgery ICU. Iran J Pharm Res. 2017 Winter;16(1):404-409. PMID: 28496494; PMCID: PMC5423266.
1. Barimani A, Donyavi R, Taghizade S. The Effectiveness of Positive Psychotherapy on Optimism and Alexithymia in Retired Female Teachers with Anxiety. Positive Psychology Research. 2020;6(2):49-64. Available from:
https://ppls.ui.ac.ir/article_25272.html?lang=en
2. Tajvar M, Arab M, Montazeri A. Determinants of health-related quality of life in elderly in Tehran, Iran. BMC public health. 2008 Dec;8(1):1-8. https://doi.org/10.1186/1471-2458-8-323
3. Hedayati B. Effect of Family-Based Empowerment Model on the Self-Efficacy of Hypertensive Elderly People. Iranian Journal of Ageing. 2018 Apr 10;13(1):86-97 . URL: http://salmandj.uswr.ac.ir/article-1-1281-en.html
4. Ursua RA, Aguilar DE, Wyatt LC, Trinh-Shevrin C, Gamboa L, Valdellon P, Perrella EG, Dimaporo MZ, Nur PQ, Tandon SD, Islam NS. A community health worker intervention to improve blood pressure among Filipino Americans with hypertension: A randomized controlled trial. Preventive medicine reports. 2018 Sep 1;11:42-8.
https://doi.org/10.1016/j.pmedr.2018.05.002
5. Chiang CE, Wang TD, Lin TH, Yeh HI, Liu PY, Cheng HM, etal. The 2017 Focused Update of the Guidelines of the Taiwan Society of Cardiology (TSOC) and the Taiwan Hypertension Society (THS) for the Management of Hypertension. Acta Cardiol Sin. 2017 May;33(3):213-225. doi: 10.6515/acs20170421a. PMID: 28559651; PMCID: PMC5445238.
6. Mahmoodabad SSM, et al. The Rate of Compliance of Prehypertension Individuals from Dietary Approaches to Stop Hypertension (DASH): An Application of the Theory of Planned Behavior. Ann Med Health Sci Res. 2019;9:448-452 Available from: https://www.amhsr.org/articles/the-rate-of-compliance-of-prehypertension-individuals-from-dietary-approaches-to-stop-hypertension-dash-an-application-o.pdf
7. Nerenberg KA, Zarnke KB, Leung AA, Dasgupta K, Butalia S, McBrien K, Harris KC, Nakhla M, Cloutier L, Gelfer M, Lamarre-Cliche M. Hypertension Canada’s 2018 guidelines for diagnosis, risk assessment, prevention, and treatment of hypertension in adults and children. Canadian Journal of Cardiology. 2018 May 1;34(5):506-25. https://doi.org/10.1016/j.cjca.2018.02.022
8. Kanamori S, Takamiya T, Inoue S. Group exercise for adults and elderly: Determinants of participation in group exercise and its associations with health outcome. The Journal of Physical Fitness and Sports Medicine. 2015 Sep 25;4(4):315-20. https://doi.org/10.7600/jpfsm.4.315
9. Ataie Z, Allahverdi A, Dehnoalian A, Orooji A. The relationship between lifestyle and general health among elderly people in Neyshabur. Iran Journal of Nursing. 2018;31(111):10-19. Available from: http://eprints.nums.ac.ir/333/1/%D8%AF%D9%87%D9%86%D9%88%D8%B9%D9%84%DB%8C%D8%A7%D9%86-%20%D8%A7%D8%B1%D8%AA%D8%A8%D8%A7%D8%B7%20%D8%B3%D8%A8%DA%A9%20%D8%B2%D9%86%D8%AF%DA%AF%DB%8C.pdf
10. Cheraghi P, Eskandari Z, Bozorgmehr S, Zanjari N, Cheraghi Z. Quality of Life and its Related Factors among Elderly People. J Educ Community Health. 2019 Jul 10;6(3):145-51. Available from: http://jech.umsha.ac.ir/article-1-620-en.html
11. Momen Abadi S, Sameni H, Zahedi Khorasani M, Vakili A. Evaluation the Nutritional Effect of Lavandula angustifolia L. Essential Oil on Normal and High Blood Pressure and Changes of the Aorta in the Rat. J. Med. Plants. 2015; 14 (56) :55-63
Available from: http://jmp.ir/article-1-1225-fa.html
12. Alizadeh A, Aghaee Z. Essential oil constituents, phenolic content and antioxidant activity of Lavandula stricta Delile growing wild in southern Iran. Natural product research. 2016 Oct 1;30(19):2253-7. https://doi.org/10.1080/14786419.2016.1155578
13. Firoozeei TS, Barekatain M, Karimi M, Zargaran A, Akhondzadeh S, Rezaeizadeh H. Lavender and dodder combined herbal syrup versus citalopram in major depressive disorder with anxious distress: A double-blind randomized trial. Journal of Integrative Medicine. 2020 Sep 1;18(5):409-15.
https://doi.org/10.1016/j.joim.2020.06.002
14. Sharma Y, Jeyabalan G, Singh R. Potential wound healing agents from medicinal plants: a review. Pharmacologia. 2013;4(5):349-58. doi : 10.5567/pharmacologia.2013.349.358
15. Nugraha A, Widyawaty E, Hernanto F, Indrianita V, Kristianto H. effect of nutmeg and lavender essential oil on blood pressure in the elderly with hypertension. PalArch's Journal of Archaeology of Egypt/Egyptology. 2020 Dec 1;17(6):10076-83. https://archives.palarch.nl/index.php/jae/article/view/2570
16. Gilani A, Aziz N, Khan M, Shaheen F, Jabeen Q, Siddiqui B, et al. Ethnopharmacological evaluation of the anticonvulsant, sedative and antispasmodic activities of Lavandula stoechas L. Journal of Ethnopharmacology. 2000;71(1-2):161-7. https://doi.org/10.1016/S0378-8741(99)00198-1
17. Lytle J, Mwatha C, Davis KK. Effect of lavender aromatherapy on vital signs and perceived quality of sleep in the intermediate care unit: a pilot study. American journal of critical care. 2014 Jan;23(1):24-9. https://doi.org/10.4037/ajcc2014958
18. Maisi S, Suryono S, Widyawati MN, Suwondo A, Kusworowulan S. Effectiveness of lavender aromatherapy and classical music therapy in lowering blood pressure in pregnant women with hypertension. Belitung Nursing Journal. 2017 Dec 28;3(6):750-6. https://doi.org/10.33546/bnj.301
19. Ahmad R, Naqvi AA, Al-Bukhaytan HM, Al-Nasser AH, Al-Ebrahim AH. Evaluation of aromatherapy with lavender oil on academic stress: a randomized placebo controlled clinical trial. Contemporary clinical trials communications. 2019 Jun 1;14:100346. https://doi.org/10.1016/j.conctc.2019.100346
20. Salamati A, Mashouf S, Mojab F. Effect of Inhalation of Lavender Essential Oil on Vital Signs in Open Heart Surgery ICU. Iran J Pharm Res. 2017 Winter;16(1):404-409. PMID: 28496494; PMCID: PMC5423266.
Objavljeno
2025/12/21
Broj časopisa
Rubrika
Originalni rad / Original article