Концентрација хемокина у серуму ЦЦЛ2 / МЦП-1 код пацијената са одонтогеним заразним и упалним обољењима меких ткива максилофацијалног подручја и медијастинума
Sažetak
The paper was aimed at determining the CCL2/ MCP-1 level in patients with OIIDs of soft tissues of the maxillofacial area and mediastinum.
The study involved 46 patients with odontogenic infectious and inflammatory diseases of soft tissues of the maxillofacial area and 12 healthy volunteers. The level of patients’ plasma CCL2 / MCP-1 level was determined using a kit for specific ELISA.
The findings of the studies showed a statistically significant increase in the concentration of plasma CCL2 / MCP-1 in patients of all study groups. Our studies show a significant increase of plasma CCL2 / MCP-1 level in patients with odontogenic phlegmons, abscesses and mediastinitis, compared to the group of healthy subjects. CCL2 / MCP-1 may play an important role in the pathogenesis of OIIDs of soft tissues of the maxillofacial area and mediastinum, which requires careful follow up study.
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3. Bali RK, Sharma P, Gaba S, Kaur A, Ghanghas P. A review of complications of odontogenic infections. Natl J Maxillofac Surg. 2015;6(2):136–143. doi:10.4103/0975-5950.183867
4. Bakathir AA, Moos KF, Ayoub AF, Bagg J. Factors Contributing to the Spread of Odontogenic Infections: A prospective pilot study. Sultan Qaboos Univ Med J. 2009;9(3):296-304.
5. Arias-Chamorro B, Contreras-Morillo M, Acosta-Moyano A, Ruiz-Delgado F, Bermudo-Añino L, Valiente-Álvarez A. Multiple odontogenic abscesses. Thoracic and abdomino-perineal extension in an immuno competent patient. Med Oral Patol Oral Cir Bucal. 2011;16:e772–5.
6. Gerrick KY, Gerrick ER, Gupta A, Wheelan SJ, Yegnasubramanian S, Jaffee EM. Transcriptional profiling identifies novel regulators of macrophage polarization. PLoS One. 2018;13(12):e0208602. Published 2018 Dec 7. doi:10.1371/journal.pone.0208602
7. Faustova MO, Ananieva MM, Basarab YO, Loban GA. Neutrophil bactericidal activity through the stages of placement of different dental implants depending on their chemical composition. Wiad Lek.2017;70(5):921-924
8. Macanas-Pirard P, Quezada T, Navarrete L, et al. The CCL2/CCR2 Axis Affects Transmigration and Proliferation but Not Resistance to Chemotherapy of Acute Myeloid Leukemia Cells. PLoS One. 2017;12(1):e0168888. Published 2017 Jan 3. doi:10.1371/journal.pone.0168888
9. Conti P, D'Ovidio C, Conti C, et al. Progression in migraine: Role of mast cells and pro-inflammatory and anti-inflammatory cytokines. Eur J Pharmacol. 2019;844:87-94. doi:10.1016/j.ejphar.2018.12.004
10. Yoshimura T. The chemokine MCP-1 (CCL2) in the host interaction with cancer: a foe or ally?. Cell Mol Immunol. 2018;15(4):335-345. doi:10.1038/cmi.2017.135
11. Declaration of Helsinki. World Medical Association. Available from: http://www.wma.net/e/ethicsunit/helsinki.htm [accessed on 24 June 2008].
12. Weise H, Naros A, Weise C, Reinert S, Hoefert S. Severe odontogenic infections with septic progress - a constant and increasing challenge: a retrospective analysis. BMC Oral Health. 2019;19(1):173. Published 2019 Aug 2. doi:10.1186/s12903-019-0866-6
13. Ananieva MM, Faustova MO, Loban GA, Avetikov DS. Microbiological aspects of chlorophyllipt extract used for prevention of candida postoperative complications Euromediterranean biomedical journal 2018;13 (39): 178–80
14. Gomes RN, Teixeira-Cunha MG, Figueiredo RT, et al. Bacterial clearance in septic mice is modulated by MCP-1/CCL2 and nitric oxide. Shock. 2013;39(1):63-69. doi:10.1097/SHK.0b013e31827802b5
15. Avetikov D. S., Buchanhenko O. P., Shlykova O. A. [et al.] Presence of Type 1 Collagen Alpha-2 (COL1A2) (rs42524) Gene Polymorphism and Scar Tissue Formation in Different Areas of Head and Neck. Pesquisa Brasileira em Odontopediatria e Clínica Integrada. 2020; Vol. 20 : e4422: P. 1–6.
16. Bianconi V, Sahebkar A, Atkin SL, Pirro M. The regulation and importance of monocyte chemoattractant protein-1. Curr Opin Hematol. 2018;25(1):44-51. doi:10.1097/MOH.0000000000000389
17. Wang Y, Liu Q, Liu T, et al. Early plasma monocyte chemoattractant protein 1 predicts the development of sepsis in trauma patients: A prospective observational study. Medicine (Baltimore). 2018;97(14):e0356. doi:10.1097/MD.0000000000010356
18. Jia T, Serbina NV, Brandl K, et al. Additive roles for MCP-1 and MCP-3 in CCR2-mediated recruitment of inflammatory monocytes during Listeria monocytogenes infection. J Immunol. 2008;180(10):6846-6853. doi:10.4049/jimmunol.180.10.6846
19. Matsumoto H, Ogura H, Shimizu K, et al. The clinical importance of a cytokine network in the acute phase of sepsis. Sci Rep. 2018;8(1):13995. Published 2018 Sep 18. doi:10.1038/s41598-018-32275-8
Objavljeno
2025/12/21
Broj časopisa
Rubrika
Originalni rad / Original article