ОДНОС ОДНОСА НЕУТРОФИЛА И ЛИМФОЦИТА И КЛИНИЧКО-ЛАБОРАТОРИЈСКИХ ПОДАТАКА КОД АКУТНОГ панкреатитиса

DOI: https://doi.org/10.5937/afmnai39-34988

Sažetak


Introduction: Neutrophil-lymphocyte ratio (NLR) is one of the laboratory biomarkers used in clinical practice to predict severity and mortality of AP, but there is currently insufficient information about changes of NLR in relationship with other clinical and laboratory data.

Objectives: to assess the relationship between NLR values and other demographics, clinical and simple laboratory data in patients with acute pancreatitis.

Materials and methods: 229 patients data with AP were analyzed.  They were divided into two groups: with a positive and fatal outcome. NLR was counted on the 1st, 3rd and 5th day after admission.

Results: The level of NLR rate itself was significantly higher on 1st, 3rd and 5th days in group with fatal result compared with the group with a positive result (p<0,05). The significant negative relationship of Spearman's rank correlation coefficient between NLR on 1st, 3rd days with fatal outcomes was revealed. In the group of patients with a positive result was found correlation between NLR and stabs, segmental forms, serum amylase and level of lymphocytes on 1st day (rs=-0.98, p<0001). In the group of patients with fatal outcome high correlation was found with the level of segmental forms (rs= 0.7) and the level of lymphocytes on 1st day (rs=-0.99).

Conclusions: Elevated NLR levels on 1st and 3rd days seem to be associated with hospital mortality in patients with AP. No correlation was found between NLR rate and clinical data in the group with fatal outcome. 

Biografije autora

Tetiana Formanchuk, Associate Professor

surgery department 2, Vinnytsya National Pirogov Memorial Medical University, Ukraine

Hryhoriy Lapshyn, PhD, Dr. med

a head of the Transplant Surgery Department, specialist in general and visceral surgery, surgery clinic, University Medical Center Schleswig-Holstein, Lübeck Campus, Germany

Mariya Pokidko, MD, Professor

a head of the Department of Surgery №2 with course of basic stomatology, National Pirogov Memorial Medical University, Vinnytsya, Ukraine

Andrii Formanchuk, PhD, Associate Professor

Department of Surgery №1 with course of urology, National Pirogov Memorial Medical University, Vinnytsya, Ukraine

Igor Vovchuk, PhD, Associate Professor

Department of Surgery №2 with course of basic stomatology, National Pirogov Memorial Medical University, Vinnytsya, Ukraine

Olha Tkachenko, Student

National Pirogov Memorial Medical University, Vinnytsya, Ukraine

Anastasiia Sychevska, student

National Pirogov Memorial Medical University, Vinnytsya, Ukraine

Olexii Lopushanskyi, student

National Pirogov Memorial Medical University, Vinnytsya, Ukraine

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Objavljeno
2025/12/21
Broj časopisa
Vol. 39 Br. 4 (2022): Acta facultatis medicae Naissensis
Rubrika
Originalni rad / Original article