Antioksidativna aktivnost derivata N,N’-disupstituisanih benzimidazol-2-tiona: in vitro studija

  • Jelena Lazarevic
  • Jelena Zvezdanović Univerzitet u Nišu, Tehnološki fakultet, Leskovac, Srbija
  • Neda Anastassova Institute of Organic Chemistry with Center of Phytochemistry, Bulgarian Academy of Sciences, Sofia, Bulgaria
  • Anelia Ts. Mavrova Institute of Organic Chemistry with Center of Phytochemistry, Bulgarian Academy of Sciences, Sofia, Bulgaria
  • Denitsa Yancheva Institute of Organic Chemistry with Center of Phytochemistry, Bulgarian Academy of Sciences, Sofia, Bulgaria
  • Andrija Šmelcerović Univerzitet u Nišu, Tehnološki fakultet, Leskovac, Srbija
DOI: https://doi.org/10.5937/afmnai39-36399
Ključne reči: antioksidantna aktivnost, lipidna peroksidacija, N,N’-disupstituisani benzimidazol-2-tioni

Sažetak


Antioksidativna aktivnost sedam N,N’-disupstituisanih benzimidazol-2-tiona, sa funkcionalizovanim bočnim nizovima u položajima 1- i 3- estarskim (1-4), odnosno hidrazidnim (5-7) grupama, ispitana je in vitro, metodom lipidne peroksidacije. Jedino hidrazidi 1,3-bis[3-(hidrazinooksi)-3-oksopropil]-1,3-dihidro-2H-benzimidazol-2-tion (5), 1,3-bis[3-(hidrazinooksi)-3-oxopropil]-5-metil-1,3-dihidro-2H-benzimidazol-2-tion (6) i 1,3-bis[3-(hidrazinooksi)-3-oxopropil]-5-benzoil-1,3-dihidro-2H-benzimidazol-2-tion (7) pokazuju dobra antioksidativna svojstva (IC50 < 100 μM), sa najboljim vrednostima inhibicije lipidne peroksidacije (IC50) za jedinjenja  5 (64 ± 10 μM) i 6 (73 ± 29 μM). Pomenuta dva jedinjenja, na osnovu in vitro dobijenih IC50 rezultata, predstavljaju dobru polaznu molekularnu osnovu i obećavajući sturkturni element u razvoju jedinjenja za prevenciju bolesti nastalih kao posledica oksidativnog oštećenja.

Reference

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Objavljeno
2025/12/21
Broj časopisa
Vol. 39 Br. 4 (2022): Acta facultatis medicae Naissensis
Rubrika
Originalni rad / Original article