Hidrolat matičnjaka (Melissa officinalis L.) nema velikog uticaja na motilitet izolovanog fundusa pacova

  • Nikola M Stojanović Faculty of Medicine, University of Niš, Niš, Serbia
  • Sara Stojanović Medicinski fakultet, Univerzitet u Nišu, Niš, Srbija
  • Bogdan Stojiljković Medicinski fakultet, Univerzitet u Nišu, Niš, Srbija
  • Aleksandar Marković Medicinski fakultet, Univerzitet u Nišu, Niš, Srbija
  • Dragana Pavlović Departman za farmaciju, Medicinski fakultet, Univerzitet u Nišu, Niš, Srbija
  • Pavle Randjelović Departman za fiziologiju, Medicinski fakultet u Nišu, Univerzitet u Nišu, Niš, Srbija
  • Jelena Zvezdanović Tehhnološki fakultet, Univerzitet u Nišu, Leskovac, Srbija
  • Ljiljana Stanojević Tehhnološki fakultet, Univerzitet u Nišu, Leskovac, Srbija
DOI: https://doi.org/10.5937/afmnai40-38933
Ključne reči: Melissa officinalis, hidrolat, gastrični fundus, kontrakcije

Sažetak


Matičnjak se vekovima koristio kao lekovita biljka zbog svojih sedativnih, antibakterijskih, antivirusnih i spazmolitičnih efekata. Osim različitih vrsta ekstrakata i etarskih ulja, hidrolati, koji se dobijaju kao nusprodukt u procesu ekstrakcije eterskih ulja, su preparati aromatičnog medicinskog bilja sa potencijalnom farmakološkim aktivnošću. Da bi se procenio uticaj hidrolata iz lista matičnjaka na poremećaje gastrične aktivnosti, njegova aktivnost je ispitivana in vitro u vodenom kupatilu na spontane kontrakcije preparata fundusa želuca pacova. Hidrolati su dodavani u rastućim koncentracijama (sa konačnom koncntracijom 0,5 – 910 µl/ml), sukcesivno, u vodeno kupatilo. Niže doze nisu uzrokovale značajnije promene u kontrakcijama fundusa želuca, dok su više dovele do statistički značajnog povećanja u bazalnom tonusu. Međutim, ove promene su bile umerene. Fitohemijska kvalitatvna karakterizacija, uređena metodom tečne hromatografije sa ultra visokim performansama, pokazala je dominantnost rozmarinske kiseline u hidrolatu M. officinalis. Iako testirani hidrolat ima slab uticaj na kontrakcije preparata fundusa želuca, dalja istraživanja bi mogla da razjasne farmakološki efekat i potencijalnu upotrebu ovog nusprodukta hidrodestilacije matičnjaka.

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Objavljeno
2025/12/09
Broj časopisa
Vol. 40 Br. 1 (2023): Acta facultatis medicae Naissensis
Rubrika
Originalni rad / Original article