engleski

Sažetak

Numerous studies have been conducted in order to identify the ideal marker when it comes to the  inflamatory bowel disease.  In addition to Fecal calprotectin (FC) is  mentioned as markers of inflammation. Elevated  of FC can be detected in the stool and indicate  intestinal inflammation. The main goal of this study is to examine the concentration of FC and CRP depending on the clinical-endoscopic-histological characteristics of patients with Cronhs disease (CD) and whether there is a correlation of these markers with disease activity. The study included subjects who had been diagnosed with CD. The study involved 45 respondents, aged 20-58 years. All subjects included in the study underwent a colonoscopic examination with biopsy and pathohistological analysis. Fecal calprotectin was determined in one stool sample in all subjects, and determination of serum CRP concentrations was performed  by standard methods.Fecal concentrations of calprotectin are elevated in all three forms of the disease, while they are significantly higher in moderately severe and severe forms of the disease compared to the mild form. Fecal concentrations of calprotectin are significantly higher at endoscopic grade 3, compared to the other three endoscopic grades. Fecal concentrations of calprotectin are  higher in extensive pathological findings compared to normal epithelial surface , as well as in extensive pathological findings compared to focal pathological findings. The severe form of clinical disease activity is accompanied by higher fecal values ​​of calprotectin and higher endoscopic grade  and severe histological grade of disease is accompanied by higher fecal values ​​of calprotectin.