PREVENTIVNI PRISUPI ORALNIM MUKOZITIMA: PREGLED LITERATURE
PREVENCIJA ORALNIH MUKOZITA
Ključne reči:
stomatitis, oralni mukozitis, hemioterapija, radioterapija, prevencija, oralni kancer
Sažetak
Uvod: Oralni mukozitis predstavlja akutno, inflamatorno i ulcerozno stanje oralne sluzokože koje je uzrokovano hemioterapijom i/ili radioterapijom. S obzirom na učestalost oralnih mukozitisa, njihov uticaj na fizičko i mentalno zdravlje pacijenata, kao i crpljenje ekonomskih kapaciteta pojedinaca i društva, jasno je naglašen njihov značaj u prevenciji i lečenju. Cilj našeg istraživanja je bio da se utvrde savremeni modaliteti u prevenciji oralnih mukozita, Materijal i metode: Pretraživanje studija indeksiranih u literaturi od 2002. do 2022. godine je sprovedeno korišićenjem Pubmed baze podataka. Pretraga je vršena prema ključnim rečima: stomatitis, mukozitis, oralni mukozitis, hemioterapija, radioterapija, prevencija, oralni karcinom. Rezultati i diskusija: Postoje brojni preventivni modaliteti za oralni mukozit, koji uključuju: edukaciju pacijenata, profesionalnu oralnu zdravstvenu zaštitu, kućnu higijenu, rastvore za ispiranje, antiinflamatorna sredstva kao što su benzidiamin, fotobiomodulacija, krioterapija, mikonazol, tečni mukoadhezivni hidrogel, polimerizovani visoko potentni umreženi sukralfat, rastvor morfijuma za ispiranje usta, faktori rasta i citokini, med, vitamin C, vitamin E, vitamin B2, cink i glutamin, Zaključak: U literaturi se kao najznačajniji izdvajaju sledeći modaliteti prevencije oralnih mukozita: benzidiamin, terapija laserom prema uputstvima dostupnim u literaturi, krioterapija, 0,2% rastvor tečnosti za ispiranje usta na bazi morfijuma i oralno primenjeni glutamin. Varijabilnost u rezultatima ukazuje na kompleksnu prirodu ovog kliničkog entiteta i potrebu za dodatnim istraživanjima koja će potkrepiti već postojeće rezultate i obogatiti literaturu novim preventivnim pristupima.
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2025/11/19
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Pregledni rad / Review article