Efekat antiinflamatornog refleksa na srce
Ključne reči:
heart disease, inflammatory reflex, vagal stimulation
Sažetak
Nativni imuni sistem je glavna komponenta odbrane od patogena, povrede i traume. Vagalna vlakna sadrže senzorne i motorne komponente koje kontrolišu funkcije kao što su srčana frekvenca i varenje. Ovaj antiinflamatorni put je bitan iz više razloga, brz je, funcioniše separatno od imunog i lokalizovan je na tkivo iz koga je povreda započela, može indukovati humoralni sistemski antiinflamatorni odgovor sa više poziticnih efekata po srce.
Reference
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33. Beaumont E, Southerland E, Hardwick J, Ryan S, KenKnight B and Ardell J. Chronic autonomic regulation therapy mitigates adverse remodeling induced by pressure overload in the guinea pig heart. J Am Coll Cardiol. 2014;63.
2. Nathan C. Points of control in inflammation. Nature 2002; 420: 846-852.
3. Wang H, Yang H and Tracey KJ. Extracellular role of HMGB1 in inflammationand sepsis. J Intern Med 2004; 255: 320-331.
4. Webster JI, Teonelli L and Sternberg EM. Neuroendocrine regulation of immunity. Annu Rev Immunol 2002; 20: 125-163.
5. Borovikova LV et al. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 2000; 405: 458-461.
6. Wang H Nicotinic acetylcholine receptor α7 subunit is an essential regulator of imflammation. Nature 2003; 421: 384-388.
7. Aderem A and Ulevitch RJ. Toll-like receptors in the induction of innate immune response. Nature 2000; 406: 782-787.
8. Seaffidi P, Misteli T and Bianchi ME. Release of chromatin protein HMGB1 by necrotic cells triggers inflamation. Nature 2002; 418: 191-195.
9. Zhang M, Wang H and Tracey KJ. Regulation of macrophage activation and inflammation by spermine: a new chapter in an old story. Crit Care Med 2000; 28 Suppl N60-N66.
10. Cohen J. The immunopathogenesis of sepsis. Nature 2002; 420: 885-891.
11. Blalock JE and Smith EM. Conceptual development of the immune system as a sixt sense. Brain Behav Immun 2007; 21: 23-33-
12. Da Salva JA. Sex hormones and glucocorticoids: interactions with the immune system. Ann N Y Acid Sci 1999; 876: 102-117.
13. Cekić S, Filipović M, Nešić M, Dimitrijević O, Pavlović M, Branković S, Ćirić M. Long-term effect of neonatal monosodium glutamate (MSG) treatment on hypothalamus pituitary-adrenal-thymus axis of rats. Virchows Archiv 2003; 443(3): 257.
14. Cekić S, Filipović M, Jović Z, Nešić M, Pešić G, Ćirić M, Petrović A, Branković S, Živanov J, Radenković M. Histopathological changes at the hypothalamic nucleus arcuatus and thyroid level in rats treated with monosodium glutamate. Acta Facultatis Medicae Naissensis 2004; 21(2): 89-94. (M53-1)
15. Cekić S, Filipović M, Pavlović V, Ćirić M, Nešić M, Jović, Branković S. Histopathologic changes at the hypothalamic nucleus arcuatus adrenal and thymus in rats treated with monosodium glutamate. Acta Medica Medianae 2005; 44(3): 35-42. (M52-1,5)
16. Rivest S, Lacroix S, Valihres I, Nadeau S. How the blood talks to the brain parenschyma and the paraventricular nucleus of the hypothalamus during systemic inflammatory and infectious stimuli. Proc Soc Exp Biol Med 2000; 223: 22-38.
17. Davis CN. MyD88-dependent and –independent signaling by IL-1 neurons probed by bifunctional Toll/IL-1 receptor domain/BB-loop mimetics. Proc Natl Acad Sci USA 2006; 103: 2953-2958.
18. Mattson MP. NF-κB in the survival and plasticity of neurons. Neurochem Res 2005; 30: 883-893.
19. Ferri CC, Yulli EA, Ferguson AV. Interleukin-1β depolarizesmagnocellular neurons in the paraventricular nucleus of the hypothalamus through prostaglandin-mediated activation of a non selective cationic conductance. Regul Pept 2005; 129: 63-71.
20. Medzihtov R. Origin and physiological roles of inflammation. Nature 2008; 428-435.
21. Blanchi ME. DAMPs, PAMPs and alarmins. All we need to know about danger. J Leukoc Biol 2007; 81: 1-5.
22. Bellinger DL, Lorton D, Lubahn C and Felten DL, in Psychoneuroimmunology (eds Ader R, Felten DL and Cohen N), Academic San Diego 2001; 55-112.
23. Houston JM. Splenectomy inactivates the cholynergic antiinflamatory pathway during lethal endotoxemia and polymicrobial sepsis. J Exp Med 2006; 203: 1623-1628.
24. Chia JE, Blennerhasset P and Collins SM. Impaired parasymphatetic function increases susceptability to inflammatory bowel disease in a mouse model of depression. J Clin Invest 2008; 118: 2209-2218
25. Parrish WR. Modulation of TNF release by choline requires α7 subunit nicotinic acetylcholine receptor-mediated signaling. Mol Med 2008; 14: 567-574.
26. Razani-Boroujerdi. T-cells ewpress α7-nicotinic acetylcholine receptor subunits that require a functional TCR and leucocyte-specific protein tyrosine kinase for nicotine-induced Ca2+ response. J Immunol 2007; 179: 2889-2898.
27. Bernik TR, et al. Pharmacological stimulation of the cholinergic antiinflammatory pathway. J Exp Med 2002; 195: 781-788.
28. Hommes D et al. Inhibiton of stress-activated MAP kinases induces clinical improvement in moderate to severe Crohns disease. Gastroenterology 2002; 122: 7-14.
29. Dias DS. Opposite effects of iv amiodarone on cardiovascular vagal and sympathetic efferent activities in rats. Am J Physiol Regul Integr Comp Physiol 2002; 283: R543-R548.
30. Li M, Zheng C, Sato T, Kawada T, Sugimachi M and Sunagawa K. Vagal nerve stimulation markedly
improves long-term survival after chronic heart failure in rats. Circulation. 2004;109:120-4.
31. Sabbah HN, Rastogi S, Mishra S, Gupta RC, Ilsar I, Imai M, Cohen U, BenDavid T and Ben- Ezra O. Long-term therapy with neuroselective electric vagus nerve stimulation improves LV function and attenuates global LV remodelling in dogs with chronic heart failure. Eur J Heart Fail. 2005:166.
32. Zhang Y, Popovic ZB, Bibevski S, Fakhry I, Sica Da, Van Wagoner DR and Mazgalev TN. Chronic vagus nerve stimulation improves autonomic control and attenuates systemic inflammation and heart failure progression in a canine high-rate pacing model. Circulation Heart failure. 2009;2:692-629.
33. Beaumont E, Southerland E, Hardwick J, Ryan S, KenKnight B and Ardell J. Chronic autonomic regulation therapy mitigates adverse remodeling induced by pressure overload in the guinea pig heart. J Am Coll Cardiol. 2014;63.
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2020/08/27
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