Insulin therapy initiation in a patient with type 2 diabetes in everday clinical practice: is there a delay?

  • Slobodan Antić Univerzitet u Nišu Medicinski Fakultet

Sažetak


Introduction: Adequate time to start insulin therapy implies when treatment of hyperglycemia is not achieved. The reasons for the delay in starting insulin therapy may be due to certain doubts that are present in patients, but also to the doctor.

Aims:  To investigate  conditions of the patients at the time of the introduction of insulin therapy in patients with type 2 diabetes and what was the condition of patients 6 months prior to the introduction of insulin therapy

Material and methods: The study included 70 patients with type 2 diabetes, introduced to  insulin therapy. The study involved an analysis of the anamnesis and clinical data according to the study protocol, and 6 months before the introduction of insulin therapy, and just before the introduction of insulin therapy.

Results:  At the time of the introduction to insulin therapy, glucose values ​​were 12.02 ± 2.54, and six months earlier values ​​were 12.18 ± 2.99. HbA1c values ​​at the time of the introduction to insulin amounted to 10.88 ± 1.65, and six months before 10.02 ± 1.67. The values ​​of BMI at the time of the introduction to insulin therapy were 28.90 ± 7:54, and six months before 28.23 ± 5.79.

Conclusion: there is deley in the initiation of insulin therapy with type 2 diabetes patients. Insulin therapy leads to improvement of glycemic control and significant reduction in HbA1c.

Reference

American Diabetes Association. Pharmacologic Approaches to Glycemic Treatment: Standards of Medical Care in Diabetes Pharmacologic Approaches to Glycemic Treatment. Diabetes Care 2020;43(1): S98–S110. [CrossRef][PubMed]

Brismar K, Benroubi M, Nicolay C, Schmitt H, Giaconia J, Reaney M. Evaluation of insulin initiation on re-source utilization and direct costs of treatment over 12 months in patients with type 2 diabetes in Europe: results from INSTIGATE and TREAT observational studies. J Med Econ 2013;16 (8):1022-35. [CrossRef][PubMed]

Buse J, Wexler D, Tsapas A, Rossing P, Mingrone G, Mathieu C, et al. 2019 update to: Management of hyperglycaemia in type 2 diabetes. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia 2020;63:221-8. [CrossRef][PubMed]

Chun J, Strong J, Urquhart S. Insulin Initiation and Titration in Patients With Type 2 Diabetes. Diabetes Spectrum 2019;32(2):104-11. [CrossRef][PubMed]

Diabetes Canada Clinical Practice Guidelines Expert Committee. Pharmacologic Glycemic Management of Type 2 Diabetes in Adults. Can J Diabetes 2018;42: S88–S103. [CrossRef][PubMed]

Đinđić B, Radić S, Antić S, Sokolović D. Znaćaj gliko-regulacije u patogenezi koronarne bolesti srca u dija-betes melitusu. Acta Medica Medianae 2000;4:12-8.

Hermansen K, Mortensen LS, Hermansen ML. Com-bining insulins with oral antidiabetic agents: effect on hyperglycemic control, markers of cardiovascular risk and disease. Vase Health Risk Manag 2008;4:561-74. [CrossRef][PubMed]

Hirsch IB, Bergenstal RM, Parkin CG, Wright E, Buse JB. A real-world approach to insulin therapy in primary care practice. Clinical Diabetes 2005;23:78-86. [CrossRef]

Holman RR, Paul SK, Bethel MA, Matthews D, Neil A. 10-Year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med 2008;359:1577-89. [CrossRef][PubMed]

Holman RR, Thome Kl, Farmer AJ, Davies M, Keenan J, Paul S, et al. Addition of biphasic, prandial, or basal insulin to oral therapy in type 2 diabetes. N Engl J Med 2007;357:1716-30. [CrossRef][PubMed]

Jenkins N, Hallowell N, Farmer AJ, Holman R, Lawton J. Initiating insulin as part of the treating to target in type 2 diabetes (4-T) trial: an interview study of patients' and health professionals' experiences. Dia-betes Care 2010;33:2178-80. [CrossRef][PubMed]

Karel K, Wolfgang R. Changes in time to insulin initiation in type 2 diabetes patients: A retrospective database analysis in Germany and UK (2005–2010). Prim Care Diabetes 2013;7(3):229-33. [CrossRef][PubMed]

Khaw KT, Wareham N, Bingham S, Luben R, Welch A, Day N. Association of hemoglobin A1c with cardio-vascular disease and mortality in adults: the European Prospective Investigation into Cancer in Norfolk. Ann Intern Med 2004;141:413-20. [CrossRef][PubMed]

Lalic NM, Micic D, Antic S, Bajovic L, Pantelinac P, Jotic A, et al. Effect of biphasic insulin aspart on glucose and lipid control in patients with Type 2 diabetes mellitus. Expert Opin Pharmacother 2007;8(17): 2895-901. [CrossRef][PubMed]

Liebl A, Jones S, Goday A, Benroubi M, Castell C, Haupt A, et al. Clinical Outcomes After Insulin Initia-tion in Patients with Type 2 Diabetes: 24-Month Re-sults from INSTIGATE. Diabetes Ther 2012;3(1):9-19. [CrossRef][PubMed]

Ligthelm R, Gylvin T, De Luzio T, Raskin P. A Comparison of Twice-Daily Biphasic Insulin Aspart 70/30 and Once-Daily Insulin Glargine in Persons with Type 2 Diabetes Mellitus Inadequately Controlled on Basal Insulin and Oral Therapy: A Randomized, Open-Label Study. Endocr Pract 2011;17(1):1-10. [CrossRef][PubMed]

Oguz A, Benroubi M, Brismar K, Melo P, Morar C, Cleall SP, et al. Clinical outcomes after 24 months of insulin therapy in patients with type 2 diabetes in five countries: results from the TREAT study. Curr Med Res Opin 2013;29(8):911-92. [CrossRef][PubMed]

Perez-Nieves M, Kabul S, Desai U, Ivanova J, Kirson N, Cummings A, et al. Basal insulin persistence, asso-ciated factors, and outcomes after treatment initi-ation among people with type 2 diabetes mellitus in the US. Curr Med Res Opin 2016;32(4):669-80. [CrossRef][PubMed]

Raskin P, Allen E, Hollander P, Lewin A, Gabbay RA, Hu P, et al. Initiating insulin therapy in type 2 dia-betes: a comparison of biphasic and basal insulin analogs. Diabetes Care 2005;28:260-65. [CrossRef][PubMed]

Republička stručna komisija za izradu i implementaciju vodiča u kliničkoj praksi. Prevencija tipa 2 dijabetesa. Nacionalni vodič za lekare u primarnoj zdravstvenoj zaštiti. Drugo izmenjeno i dopunjeno izdanje. Beograd: Ministarstvo zdravlja Republike Srbije, jul 2012.

Russell-Jones D, Vaag A, Schmitz O, Sethi BK, Lalic N, Antic S, et al. Liraglutide vs insulin glargine and pla-cebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): a randomised controlled trial. Diabetologia 2009;2 (10):2046-55. [CrossRef][PubMed]

Selvin E, Marinopoulos S, Berkenblit G, Rami T, Brancati F, Powe N, et al. Meta-analysis: glycosylated hemoglobin and cardiovascular disease in diabetes mellitus. Ann Intern Med 2004;141:421-31. [CrossRef][PubMed]

Stratton IM, Adler IM, Neil HA, Matthews DR, Manley SD, Cull CA. Association of glycaemia with macro-vascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ 2000;321:405-12. [CrossRef][PubMed]

The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993;329:977-86. [CrossRef][PubMed]

UKPDS. Intensive blood-glucose control with sulpho-nylureas or insulin compared with conventional treat-ment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet 1998;352:837-53. [CrossRef][PubMed]

Velojic-Golubovic M, Mikic D, Pesic M, Dimic D, Radenkovic S, Antic S. Biphasic insulin aspart 30: Better glycemic control than with premixed human insulin 30 in obese patients with Type 2 diabetes. J Endocrinol Invest 2009;32(1):23-27. [CrossRef][PubMed]

Virally M, Blicklé J-F, Girard J, Halimi S, Simon D, Guillausseau P.-J. Type 2 diabetes mellitus: epide-miology, pathophysiology, unmet needs and thera-peutical perspectives. Diabetes Metab 2007;33(4): 231-44. [CrossRef][PubMed]

Wattanakita K, Folsoma AR, Selvinb E, Weatherleyc B, Pankowa J, Brancatib FL, et al. Risk factors for peripheral arterial disease incidence in persons with diabetes: the Atherosclerosis Risk in Communities (ARIC) Study. Atherosclerosis 2005;180:389-97. [CrossRef][PubMed]

Objavljeno
2020/12/29
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