KLINIČKI ZNAČAJ EKSPRESIJE CD44 KOD SEROZNOG KARCINOMA JAJNIKA
EKSPRESIJA CD44 KOD KARCINOMA JAJNIKA
Sažetak
Karacinom jajnika je bolest koja uzrokuje više od 180.000 smrtnih slučajeva godišnje, sa često podmuklim tokom, kasnom simptomima i kliničkom dijagnozom i ograničenim odgovorom na terapiju. Površinski glikoprotein CD44 je uključen u širenje i pojavu metastaza u različitim vrstama karcinoma, uključujući i serozni karcinom jajnika. Ovo istraživanje imalo je za cilj da istraži profil imunohistohemijske ekspresije CD44 kod seroznog karcinoma jajnika i da utvrdi njegov potencijalni značaj u prognozi bolesti. Na ekspresiju CD44 analizirano je ukupno 124 primarnih seroznih karcinoma janika imunohistohemijskim metodama i procenjena je moguća povezanost sa kliničkim i patološkim parametrima, kao i sa preživljavanjem pacijenata. Primećena je visoka ekspresija CD44 kod 67,7% ispitivanih tumora. Pozitivna porodična anamneza maligniteta bila je povezana sa niskom ekspresijom CD44 u ćelijama karcinoma (p = 0,004). Niska ekspresija CD44 bila je češća kod tumora u FIGO stadijumu IV nego u ostalim stadijumima, kao i kod karcinoma visokog gradusa u poređenju sa karcinomima niskog gradusa, međutim ove razlike nisu bile statistički značajne. Prosečno preživljavanje bilo je značajno duže kod pacijenata sa visokom ekspresijom CD44 u poređenju sa onima kod kojih je bila odsutna ili slaba ekspresija CD 44 (p = 0,009). Smrtni ishod tokom perioda praćenja dogodio se kod 65% pacijenata sa niskom ekspresijom CD44 i u 42,86% pacijenata sa visokom ekspresijom CD44, sa statistički značajnom razlikom između grupa (p = 0,035). Istraživanje je pokazalo da je nepovoljni klinički tok seroznog karcinoma jajnika bio povezan sa odsutvom ekspresije ili slabom ekspresijom CD44.
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