MED, VIŠE OD HRANE: MOGUĆNOST PRIMENE U REGENERATIVNOJ MEDICINI
Sažetak
Med je od davnina prepoznat kao dragoceni prirodni produkt, ne samo zbog svoje nutritivne vrednosti, već i zbog svojih lekovitih svojstava. Iako je u najvećoj meri sačinjen od ugljenih hidrata, on sadrži i brojne enzime, aminokiseline, organske kiseline, polifenole, minerale, vitamine i druge supstance, čija zastupljenost varira u zavisnosti od vrste meda i njegovog botaničkog i geografskog porekla. Zahvaljujući svojim antimikrobnim svojstvima, kao i blagotvornom efektu na zarastanje rana, reparaciju i regeneraciju tkiva, med može imati potencijalnu ulogu u oblastima tkivnog inženjerstva i regenerativne medicine.
Reference
Alvarez-Suarez JM, Gasparrini M, Forbes-Hernández TY, Mazzoni L, Giampieri F. The Composition and Biological Activity of Honey: A Focus on Manuka Honey. Foods 2014;3(3):420-32. [CrossRef] [PubMed]
Kunieda T, Fujiyuki T, Kucharski R, Foret S, Ament SA, Toth AL, et al. Carbohydrate metabolism genes and pathways in insects: insights from the honey bee genome. Insect Mol Biol 2006;15(5):563-76. [CrossRef] [PubMed]
Schievano E, Finotello C, Uddin J, Mammi S, Piana L. Objective Definition of Monofloral and Polyfloral Honeys Based on NMR Metabolomic Profiling. J Agric Food Chem 2016;64(18):3645-52. [CrossRef] [PubMed]
Martinotti S, Calabrese G, Ranzato E. Honeydew honey: biological effects on skin cells. Mol Cell Biochem 2017;435(1-2):185-92. [CrossRef] [PubMed]
Eteraf-Oskouei T, Najafi M. Traditional and modern uses of natural honey in human diseases: a review. Iran J Basic Med Sci 2013;16(6):731-42. [PubMed]
Miguel MG, Antunes MD, Faleiro ML. Honey as a Complementary Medicine. Integr Med Insights 2017; 12:1178633717702869. [CrossRef] [PubMed]
Ahmed S, Sulaiman SA, Baig AA, Ibrahim M, Liaqat S, Fatima S, et al. Honey as a Potential Natural Anti-oxidant Medicine: An Insight into Its Molecular Mecha-nisms of Action. Oxid Med Cell Longev 2018: 8367846. [CrossRef] [PubMed]
Krafts KP. Tissue repair: The hidden drama. Organo-genesis. 2010;6(4):225-33. [CrossRef] [PubMed]
Martinotti S, Ranzato E. Honey, Wound Repair and Regenerative Medicine. J Funct Biomater 2018;9(2): 34. [CrossRef] [PubMed]
Samarghandian S, Farkhondeh T, Samini F. Honey and Health: A Review of Recent Clinical Research. Pharmacognosy Res 2017;9(2):121-7. [CrossRef] [PubMed]
Kamal MA, Klein P. Determination of sugars in honey by liquid chromatography. Saudi J Biol Sci 2011; 18(1):17-21. [CrossRef] [PubMed]
Albaridi NA. Antibacterial Potency of Honey. Int J Microbiol 2019:2464507. [CrossRef] [PubMed]
Bogdanov S, Jurendic T, Sieber R, Gallmann P. Honey for nutrition and health: a review. J Am Coll Nutr 2008;27(6):677-89. [CrossRef] [PubMed]
da Silva PM, Gauche C, Gonzaga LV, Costa AC, Fett R. Honey: Chemical composition, stability and authenti-city. Food Chem 2016;196:309-23. [CrossRef] [PubMed]
Cianciosi D, Forbes-Hernández TY, Afrin S, Gasparrini M, Reboredo-Rodriguez P, Manna PP, et al. Phenolic Compounds in Honey and Their Associated Health Benefits: A Review. Molecules 2018;23(9):2322. [CrossRef] [PubMed]
Oryan A, Alemzadeh E, Moshiri A. Biological properties and therapeutic activities of honey in wound healing: A narrative review and meta-analysis. J Tissue Viability 2016;25(2):98-118. [CrossRef] [PubMed]
Erban T, Shcherbachenko E, Talacko P, Harant K. The Unique Protein Composition of Honey Revealed by Comprehensive Proteomic Analysis: Allergens, Venom-like Proteins, Antibacterial Properties, Royal Jelly Proteins, Serine Proteases, and Their Inhibitors. J Nat Prod 2019;82(5):1217-26. [CrossRef] [PubMed]
Anklam E. A review of the analytical methods to determine the geographical and botanical origin of honey. Food Chem 1998;63:549-62. [CrossRef]
Pereira DM, Valentão P, Pereira JA, Andrade PB. Phenolics: From Chemistry to Biology. Molecules 2009;14(6):2202-11. [CrossRef] [PubMed]
Mato I, Huidobro JF, Simal-Lozano J, Sancho MT. Significance of nonaromatic organic acids in honey. J Food Prot 2003;66(12):2371-6. [CrossRef] [PubMed]
Singh V, Pal US, Singh R, Soni N. Honey a sweet approach to alveolar osteitis: a study. Natl J Maxillofac Surg 2014;5(1):31-4. [CrossRef] [PubMed]
Masoura M, Passaretti P, Overton TW, Lund PA, Gkatzionis K. Use of a model to understand the synergies underlying the antibacterial mechanism of H2O2-producing honeys. Sci Rep 2020;10(1):17692. [CrossRef] [PubMed]
Matzen RD, Zinck Leth-Espensen J, Jansson T, Nielsen DS, Lund MN, Matzen S. The Antibacterial Effect In Vitro of Honey Derived from Various Danish Flora. Dermatol Res Pract 2018;2018:7021713. [CrossRef]
Nolan VC, Harrison J, Cox JAG. Dissecting the Anti-microbial Composition of Honey. Antibiotics (Basel) 2019;8(4):251. [CrossRef] [PubMed] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963415/
Schepartz AI, Subers MH. The glucose oxidase of honey. I. Purification and some general properties of the enzyme. Biochim Biophys Acta 1964;85:228-37. [CrossRef] [PubMed]
Bang LM, Buntting C, Molan P. The effect of dilution on the rate of hydrogen peroxide production in honey and its implications for wound healing. J Altern Com-plement Med 2003;9(2):267-73. [CrossRef] [PubMed]
Brudzynski K. Effect of hydrogen peroxide on anti-bacterial activities of Canadian honeys. Can J Microbiol 2006;52(12):1228-37. [CrossRef] [PubMed]
Kwakman PH, te Velde AA, de Boer L, Speijer D, Vandenbroucke-Grauls CM, Zaat SA. How honey kills bacteria. FASEB J 2010;24(7):2576-82. [CrossRef] [PubMed]
Brudzynski K. A current perspective on hydrogen peroxide production in honey. A review. Food Chem 2020;332:127229. [CrossRef] [PubMed]
Bucekova M, Buriova M, Pekarik L, Majtan V, Majtan J. Phytochemicals-mediated production of hydrogen peroxide is crucial for high antibacterial activity of honeydew honey. Sci Rep 2018;8(1):9061.[CrossRef] [PubMed]
Srećković NZ, Mihailović VB, Katanić Stanković JS. Physico-chemical, antioxidant and antibacterial pro-perties of three different types of honey from Central Serbia. Kragujevac J Sci 2019;41:53-68.
Leyva-Jimenez FJ, Lozano-Sanchez J, Borras-Linares I, Cadiz-Gurrea MDLL, Mahmoodi-Khaledi E, Cadiz-Gurrea ML. Potential antimicrobial activity of honey phenolic compounds against Gram positive and Gram negative bacteria. LWT 2019;101:236-45. [CrossRef]
Kwakman PH, Zaat SA. Antibacterial components of honey. IUBMB Life. 2012;64(1):48-55. [CrossRef] [PubMed]
Ganz T. Defensins: antimicrobial peptides of innate immunity. Nat Rev Immunol 2003;3(9):710-20. [CrossRef] [PubMed]
Casteels P, Ampe C, Jacobs F, Tempst P. Functional and chemical characterization of Hymenoptaecin, an antibacterial polypeptide that is infection-inducible in the honeybee (Apis mellifera). J Biol Chem 1993; 268(10):7044-54. [PubMed]
Rabie E, Serem JC, Oberholzer HM, Gaspar AR, Bester MJ. How methylglyoxal kills bacteria: An ultra-structural study. Ultrastruct Pathol 2016;40(2):107-11. [CrossRef] [PubMed]
Iftikhar F, Arshad M, Rasheed F, Amraiz D, Anwar P, Gulfraz M. Effects of Acacia Honey on Wound Healing in Various Rat Models. Phytother Res 2010;24:583-6. [CrossRef] [PubMed]
Mphande AN, Killowe C, Phalira S, Jones HW, Harrison WJ. Effects of honey and sugar dressings on wound healing. J Wound Care 2007;16(7):317-9. [CrossRef] [PubMed]
Abd Ghafar N, Ker-Woon C, Hui CK, Mohd Yusof YA, Wan Ngah WZ. Acacia honey accelerates in vitro corneal ulcer wound healing model. BMC Complement Altern Med. 2016;16:259. [CrossRef] [PubMed]
Cho M, Hunt TK, Hussain MZ. Hydrogen peroxide stimulates macrophage vascular endothelial growth factor release. Am J Physiol Heart Circ Physiol. 2001; 280(5):H2357-63. [CrossRef] [PubMed]
Najdanović J, Cvetković V, Vukelić-Nikolić M, Stojanović S, Živković J, et al. Vasculogenic potential of adipose-derived mesenchymal stem cells in vitro induced into osteoblasts applied with platelet-rich plasma in an ectopic osteogenic model. Acta med Median. 2019;58(4):57-65.
Najdanović J, Cvetković V, Stojanović S, Vukelić-Nikolić M, Stanisavljević M, Živković JM, et al. The Influence of Adipose-Derived Stem Cells Induced into Endothelial Cells on Ectopic Vasculogenesis and Osteogenesis. Cel Mol Bioeng 2015;8:577-90. [CrossRef]
Najdanović JG, Cvetković VJ, Stojanović S, Vukelić-Nikolić MĐ, Čakić-Milošević MM, Živković J M, et al. Effects of bone tissue engineering triad components on vascularization process: comparative gene ex-pression and histological evaluation in an ectopic bone-forming model. Biotechnol Biotechnol Equip 2016;30(6):1122-31. [CrossRef]
Živković JM, Vukelić-Nikolić MĐ, Najdanović JG, Stojanović S, Vitorović JS, Radenković MB, et al. Bone tissue engineering based on bone marrow in blood clot loaded on mineral matrix carrier: Experimental study in subcutaneous mice model. Acta med Median 2017; 56(3):5-11.
Martinotti S, Laforenza U, Patrone M, Moccia F, Ranzato E. Honey-Mediated Wound Healing: H₂O₂ Entry through AQP3 Determines Extracellular Ca2+ Influx. Int J Mol Sci 2019;20(3):764. [CrossRef] [PubMed]
Majtan J. Honey: an immunomodulator in wound healing. Wound Repair Regen. 2014;22(2):187-92. [CrossRef] [PubMed]
Živković JM, Stojanović ST, Vukelić-Nikolić MĐ, Radenković MB, Najdanović JG, Ćirić M, et al. Macrophages' contribution to ectopic osteogenesis in combination with blood clot and bone substitute: possibility for application in bone regeneration strategies. Int Orthop 2021;45(4):1087-95. [CrossRef] [PubMed]
Živković JM, Najman SJ, Vukelić MĐ, Stojanović S, Aleksić MV, Stanisavljević MN, et al. Osteogenic effect of inflammatory macrophages loaded onto mineral bone substitute in subcutaneous implant. Arch Biol Sci, Belgrade 2015;67(1):173-86. [CrossRef]
Živković JM, Najman SJ, Stojanović S, Najdanović JG. Interactions between skeletal system and macro-phages in homeostasis and bone injury. FU Med Biol 2016;18(1):6-11.
Tonks AJ, Cooper RA, Jones KP, Blair S, Parton J, Tonks A. Honey stimulates inflammatory cytokine production from monocytes. Cytokine 2003;21(5): 242-7. [CrossRef] [PubMed]
Candiracci M, Piatti E, Dominguez-Barragán M, García-Antrás D, Morgado B, Ruano D, et al. Anti-inflam-matory activity of a honey flavonoid extract on lipopolysaccharide-activated N13 microglial cells. J Agric Food Chem 2012;60(50):12304-11. [CrossRef] [PubMed]
Martinotti S, Bucekova M, Majtan J, Ranzato E. Honey: An Effective Regenerative Medicine Product in Wound Management. Curr Med Chem 2019;26(27):5230-40. [CrossRef] [PubMed]
Bucekova M, Sojka M, Valachova I, Martinotti S, Ranzato E, Szep Z, et al. Bee-derived antibacterial peptide, defensin-1, promotes wound re-epithelia-lisation in vitro and in vivo. Sci Rep. 2017;7(1):7340. [CrossRef] [PubMed]
Hajizadeh F, Derakhshan B, Peimani A, Abbasi Z. Effect of Topical Honey on Mandibular Bone Defect Healing in Rats. J Contemp Dent Pract. 2018;19(1): 47-51. [CrossRef] [PubMed]
Vukelić-Nikolić MĐ, Najman SJ, Vasiljević PJ, Jevtović-Stoimenov TM, Cvetković VJ, Andrejev MN, et al. Osteogenic capacity of diluted platelet-rich plasma in ectopic bone-forming model: Benefits for bone rege-neration. J Craniomaxillofac Surg. 2018;46(11): 1911-8. [CrossRef] [PubMed]
Najman SJ, Cvetković VJ, Najdanović JG, Stojanović S, Vukelić-Nikolić MĐ, Vučković I, et al. Ectopic osteo-genic capacity of freshly isolated adipose-derived stromal vascular fraction cells supported with platelet-rich plasma: A simulation of intraoperative procedure. J Craniomaxillofac Surg 2016;44(10):1750-60. [CrossRef] [PubMed] https://www.sciencedirect.com/science/article/pii/S1010518216301792?via%3Dihub
Cvetković VJ, Najdanović JG, Vukelić-Nikolić MĐ, Stojanović S, Najman SJ. Osteogenic potential of in vitro osteo-induced adipose-derived mesenchymal stem cells combined with platelet-rich plasma in an ectopic model. Int Orthop 2015;39(11):2173-80. [CrossRef] [PubMed]
Bigham-Sadegh A, Karimi I, Hoseini F, Oryan A, Sharifi S, Pakzad A. Effects of Honey and Hydro-xyapatite on Bone Healing in Rats. Trauma Monthly 2018;23(4). [CrossRef]
Elbagoury EF, Fayed NA. Application of "natural honey" after surgical removal of impacted third molar. Egypt Dent J 1985;31(3):203-11. [PubMed]
Bonifacio MA, Cochis A, Cometa S, Scalzone A, Gentile P, Procino G, Milano S, Scalia AC, Rimondini L, De Giglio E. Advances in cartilage repair: The influence of inorganic clays to improve mechanical and healing properties of antibacterial Gellan gum-Manuka honey hydrogels. Mater Sci Eng C Mater Biol Appl 2020;108: 110444. [CrossRef] [PubMed]
Hixon KR, Lu T, Carletta MN, McBride-Gagyi SH, Janowiak BE, Sell SA. A preliminary in vitro evaluation of the bioactive potential of cryogel scaffolds in-corporated with Manuka honey for the treatment of chronic bone infections. J Biomed Mater Res B Appl Biomater 2018;106(5):1918-33. [CrossRef] [PubMed]
Leong AG, Herst PM, Harper JL. Indigenous New Zealand honeys exhibit multiple anti-inflammatory activities. Innate Immun 2012;18(3):459-66. [CrossRef] [PubMed]
Ranzato E, Martinotti S, Burlando B. Epithelial mesenchymal transition traits in honey-driven kera-tinocyte wound healing: comparison among different honeys. Wound Repair Regen 2012;20(5):778-85. [CrossRef] [PubMed]
Sell SA, Wolfe PS, Spence AJ, Rodriguez IA, McCool JM, Petrella RL, Garg K, Ericksen JJ, Bowlin GL. A preliminary study on the potential of manuka honey and platelet-rich plasma in wound healing. Int J Biomater 2012;2012:313781. [CrossRef] [PubMed]
Minden-Birkenmaier BA, Bowlin GL. Honey-Based Templates in Wound Healing and Tissue Engineering. Bioengineering 2018;5:46. [CrossRef] [PubMed]