IMPLIKACIJE OKSIDATIVNOG STRESA KOD BOLESNIKA U ZAVRŠNOJ FAZI HRONIČNE BOLESTI BUBREGA: PREGLED KAUZATIVNIH MEHANIZAMA I TRENUTNIH KONCEPATA
Sažetak
Oksidativni stres (OS), označen kao disbalans između antioksidanasa i prooksidanasa, u korist potonjih, ima izraženu prevalenciju kod hronične bolesti bubrega (HBB), čak i u ranim fazama bolesti i postepeno se povećava, paralelno sa deterioracijom bubrega. U završnoj fazi hronične bolesti bubrega, OS se dalje pogoršava i povezuje se različitim nepovoljnim isho-dima, uključujući aterosklerozu i kardiovaskularne bolesti. U ovom pregledu, cilj je da predstavimo kliničke implikacije OS, patogenetske kauzativne mehanizme i potencijalne terapeutske intervencije, kod bolesnika na hemodijalizi i peritonealnoj dijalizi.
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