SADRŽAJ BETAINA U SIROVOM KRAVLJEM I OVČIJEM MLEKU

  • Jelena Zivkovic
  • Nataša Trutić University of Niš, Faculty of Medicine, Department of Chemistry, Niš, Serbia
  • Slavica Sunarić University of Niš, Faculty of Medicine, Research Centre for Biomedicine Niš, Serbia
  • Slavoljub Živanović University of Niš, Faculty of Medicine, Department of Physics, Niš, Serbia
  • Tatjana Jovanović University of Niš, Faculty of Medicine, Department of Biochemistry, Niš, Serbia
  • Gordana Kocić University of Niš, Faculty of Medicine, Department of Biochemistry, Niš, Serbia
  • Radmila Pavlović University of Milan, Department of Veterinary Science and Public Health, Milan, Italy
Ključne reči: betain, kravlje mleko, ovčije mleko, HPLC metoda

Sažetak


Betain (trimetilglicin) postoji na fiziološkoj pH vrednosti u cviterjonskom obliku. Deluje kao donor metil grupa, osmolit i lipotropni agens. Iako je ovaj mikronutrijent vredan sastojak zdrave ishrane, još uvek postoje samo ograničeni podaci o njegovom sadržaju u različitim namirnicama. Cilј ovog istraživanja bio je da se utvrdi sadržaj betaina u sirovom, neprerađenom kravlјem i ovčijem mleku sa gazdinstava u Jugoistočnoj Srbiji. Sadržaj masti i proteina u sirovom kravlјem mleku iznosio je 4,20% ± 0,38% i 3,25% ± 0,12%, respektivno. Zatim, sadržaj masti i proteina u sirovom ovčijem mleku bio je 6,67% ± 0,33% i 5,58% ± 0,16%, respektivno. Sadržaj betaina u sirovom kravlјem i ovčijem mleku iznosio je 7,51 mg/l ± 0,66 mg/l i 15,68 mg/l ± 3,52 mg/l, respektivno. S obzirom na značaj betaina, kao važnog mikronutrijenta, njegov dvostruko veći sadržaj, u ovčijem nego u kravljem mleku, doprinosi visokoj nutritivnoj vrednosti ovčijeg mleka.

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Balthazar CF, Pimentel TC, Ferrão LL, Almada CN, Santillo A, Albenzio M, et al. Sheep Milk: Physico-chemical Characteristics and Relevance for Functional Food Development. Compr Rev Food Sci Food Saf 2017;16(2):247-62. [CrossRef] [PubMed]

ChemDraw. Available from: http://www.cambridgesoft.com/software/overview.aspx 

Cho E, Zeisel SH, Jacques P, Selhub J, Dougherty L, Colditz GA, et al. Dietary choline and betaine assessed by food-frequency questionnaire in relation to plasma total homocysteine concentration in the Framingham Offspring Study. Am J Clin Nutr 2006;83(4):905-11. [CrossRef] [PubMed]

Chu DM, Wahlqvist ML, Chang HY, Yeh NH, Lee MS. Choline and betaine food sources and intakes in Taiwanese. Asia Pac J Clin Nutr 2012;21(4):547-57. [PubMed]

Craig AS. Betaine in human nutrition. Am J Clin Nutr 2004:80(3);539-49.  [CrossRef] [PubMed]

de Zwart FJ, Slow S, Payne RJ, Lever M, George PM, Gerrard JA, Chambers ST. Glycine betaine and glycine betaine analogues in common foods. Food Chem 2003;83(2):197-204. [CrossRef]

Fedotova MV. Compatible osmolytes-bioprotectants: is there a common link between their hydration and their protective action under abiotic stresses? J Mol Liq 2019;292:1-19. [CrossRef] [PubMed]

Ferro MM, Tedeschi LO, Atzori AS. The comparison of the lactation and milk yield and composition of selected breeds of sheep and goats. Transl Anim Sci 2017;1(4):498-506. [CrossRef] [PubMed]

Figueroa-Soto CG, Valenzuela-Soto EM. Glycine betaine rather than acting only as an osmolyte also plays a role as regulator in cellular metabolism. Biochimie 2018;147:89-97. [CrossRef] [PubMed]

Flis Z, Molik E. Importance of Bioactive Substances in Sheep's Milk in Human Health. Int J Mol Sci 2021; 22(9):4364. [CrossRef] [PubMed]

Forcato DO, Carmine MP, Echeverría GE, Pécora RP, Kivatinitz SC. Milk Fat Content Measurement by a Simple UV Spectrophotometric Method: An Alternative Screening Method. J Dairy Sci 2005:88(2);478-81. [CrossRef] [PubMed]

IBM Corp. IBM SPSS Statistics for Windows [Internet]. Armonk, NY: IBM Corp; 2017. Available from: https://hadoop.apache.org

Kempson SA, Vovor-Dassu K, Day C. Betaine transport in kidney and liver: use of betaine in liver injury. Cell Physiol Biochem 2013;32(7):32-40. [CrossRef] [PubMed]

Lever M, George PM, Atkinson W, Molyneux SL, Elmslie JL, Slow S et al.  Plasma lipids and betaine are related in an acute coronary syndrome cohort. PLoS One 2011;6(7):e21666. [CrossRef] [PubMed]

Lever M, Slow S. The clinical significance of betaine, an osmolyte with a key role in methyl group metabo-lism. Clin Biochem 2010;43(9):732-44. [CrossRef] [PubMed]

Lowry OH, Rosebrough NJ, Farr A.L., Randall R.J., Protein measurement with the Folin phenol reagent.  J Biol Chem 1951:193(1);265-75. [CrossRef] [PubMed]

Mahmoud AM, Ali MM. Methyl Donor Micronutrients that Modify DNA Methylation and Cancer Outcome. Nutrients 2019;11(3):608. [CrossRef] [PubMed]

Melse-Boonstra A. Bioavailability of Micronutrients From Nutrient-Dense Whole Foods: Zooming in on Dairy, Vegetables, and Fruits. Front Nutr 2020;7:101. [CrossRef] [PubMed]

Michaelidou MA. Factors influencing nutritional and health profile of milk and milk products. Small Rum Res 2008;79(1):42-50. [CrossRef]

Obeid R. The metabolic burden of methyl donor deficiency with focus on the betaine homocysteine methyltransferase pathway. Nutrients 2013;5(9): 3481-95. [CrossRef] [PubMed]

Polberger S, Lönnerdal B. Simple and rapid macro-nutrient analysis of human milk for individualized fortification: basis for improved nutritional manage-ment of very-low-birth-weight infants? J Pediatr Gastroenterol Nutr 1993:17(3);283-90. [CrossRef] [PubMed]

Pulina G, Milán MJ, Lavín MP, Theodoridis A, Morin E, Capote J, Thomas DL, Francesconi AHD, Caja G. Invited review: Current production trends, farm structures, and economics of the dairy sheep and goat sectors. J Dairy Sci 2018;101(8):6715-29. [CrossRef] [PubMed]

Radišić R, Sredojević Z, Perišić P. Some economic indicators of production of cow's milk in the Republic of Serbia. Ekonomika Poljoprivrede 2021;68(1):113-26. [CrossRef]

Roy D, Ye A, Moughan PJ, Singh H. Composition, Structure, and Digestive Dynamics of Milk From Different Species-A Review. Front Nutr 2020;7: 577759. [CrossRef] [PubMed]

Slow S, Donaggio M, Cressey PJ, Lever M, George PM, Chambers ST. The betaine content of New Zealand foods and estimated intake in the New Zealand diet. J Food Compos Anal 2005;18:473-85. [CrossRef]

Thorning TK, Raben A, Tholstrup T, Soedamah-Muthu SS, Givens I, Astrup A. Milk and dairy products: good or bad for human health? An assessment of the totality of scientific evidence. Food Nutr Res 2016;60: 32527. [CrossRef] [PubMed]

Valayanopoulos V, Schiff M, Guffon N, Nadjar Y, García-Cazorla A, Martinez-Pardo Casanova M, et al. Betaine anhydrous in homocystinuria: results from the RoCH registry. Orphanet J Rare Dis 2019;14(1):66. [CrossRef] [PubMed]

Verduci E, D'Elios S, Cerrato L, Comberiati P, Calvani M, Palazzo S, et al. Cow's Milk Substitutes for Children: Nutritional Aspects of Milk from Different Mammalian Species, Special Formula and Plant-Based Beverages. Nutrients 2019;11(8):1739. [CrossRef] [PubMed]

Wang Z, Yao T, Pini M, Zhou Z, Fantuzzi G, Song Z. Betaine improved adipose tissue function in mice fed a high-fat diet: a mechanism for hepatoprotective effect of betaine in nonalcoholic fatty liver disease. Am J Physiol Gastrointest Liver Physiol 2010;298(5):G634-42. [CrossRef] [PubMed]

Yonemori KM, Lim U, Koga KR, Wilkens LR, Au D, Boushey CJ, et al. Dietary choline and betaine intakes vary in an adult multiethnic population. J Nutr 2013; 143(6): 894-9. [CrossRef] [PubMed]

Zeisel SH, Blusztajn JK. Choline and human nutrition. Annu Rev Nutr 1994;14:269-96. [CrossRef] [PubMed]

Zeisel SH, Mar MH, Howe JC, Holden JM. Concen-trations of choline-containing compounds and betaine in common foods. J Nutr 2003;133(5):1302-7. [CrossRef] [PubMed]

Zeisel SH. Metabolic crosstalk between choline/1-carbon metabolism and energy homeostasis. Clin Chem Lab Med 2013;51(3):467-75. [CrossRef] [PubMed]

Živković J, Trutić N, Sunarić S, Živanović S, Jovanović T, Kocić G, et al. Assessment of betaine content in commercial cow and goat milk. Int Food Res J 2021:28(5):1048-56. [CrossRef]

Objavljeno
2022/11/25
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