SINTEZA I PROCENA ANTIMIKROBNE AKTIVNOSTI MONOSUPSTITUISANIH DERIVATA 3′,4′-DIMETOKSIHALKONA

  • Valentina Gocić
  • Ana Marković Katedra Farmacija, Medicinski fakultet Univerzitet u Nišu, Bulevar Dr Zorana Đinđića 81, 18000, Niš, Srrbia
  • Nikola Krstić
  • Jelena Lazarevic
Ključne reči: halkonski derivati, sinteza, antibakterijska aktivnost

Sažetak


Monosupstituisani 3′,4′-dimetoksihalkonski derivati sintetisani su bazno katalizovanom Klajzen-Šmitovom kondenzacijom, strukturno okarakterisani i podvrgnuti in vitro ispitivanju antibakterijske aktivnosti na laboratorijske sojeve Gram-pozitivnih (Bacillus subtilis ATCC 6633 i Staphylococcus aureus ATCC 6538) i Gram-negativnih (Escherichia coli ATCC 8739 i Salmonela typhimurium ATCC 14028) bakterija. 4-Brom-3′,4′-dimetoksihalkon deluje baktericidno na Gram-negativne sojeve, ispoljavajući snažniji antimikrobni efekat prema E. coli (11 mm ± 0,3 mm), u odnosu na S. typhimurium (15 mm ± 0,7 mm). Rezultati antimikrobnog testa ukazuju na potencijalni značaj pozicije 4-A-prstena halkona u kreiranju antibakterijskih agenasa selektivnog dejstva.

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Objavljeno
2023/02/06
Broj časopisa
Vol. 61 Br. IV (2022): Acta medica Medianae
Rubrika
Originalni rad