UTICAJ COVID-19 PANDEMIJE NA STRUKTURU BOLESNIKA PODVRGNUTIH OPERATIVNOM LEČENJU ZBOG UROONKOLOŠKIH INDIKACIJA
Sažetak
Cilj ove retrospektivne studije bio je da ispita uticaj pandemije COVID-19 na strukturu bolesnika koji su zbog onkoloških indikacija bili podvrgnuti operativnom lečenju na Klinici za urologiju Univerzitetskog kliničkog centra u Nišu u periodu od marta 2018. godine do juna 2022. godine. Istraživanjem su bili obuhvaćeni sledeći operativni zahvati: nefrektomija zbog karcinoma bubrega, nefroureterektomija zbog karcinoma gornjeg urotela, prostatektomija zbog karcinoma prostate, cistektomija zbog karcinoma mokraćne bešike, orhiektomija zbog tumora testisa i amputacija penisa zbog karcinoma penisa. Uzeti su podaci o broju operacija, godinama starosti i polu bolesnika, kao i postoperativni histopatološki nalazi. Operativne procedure podeljene su u dve grupe: pre COVID grupa uključila je procedure sprovedene pre početka pandemije (1. mart 2018. godine – 1. mart 2020. godine), a COVID grupa one sprovedene nakon početka pandemije COVID-19 (jun 2020. godine – jun 2022. godine). Urađeno je ukupno 569 uroonkoloških operacija ‒ 320 pre početka pandemije i 249 nakon početka pandemije. U obema ispitivanim grupama najčešće sprovedene procedure bile su nefrektomije. Statistički značajan pad broja prostatektomija i nefrektomija registrovan je u toku pandemije. Udeo prostatektomija bio je statistički značajno manji u COVID grupi, dok je udeo cistektomija u njoj statistički značajno porastao. Učestalost T4 stadijuma karcinoma mokraćne bešike bila je statistički značajno veća tokom pandemije, a učestalost T3a stadijuma značajno manja. Rezultati u vezi sa tumorskim stadijumima, dobijeni nakon svih operativnih procedura ispitanih u ovoj studiji, pokazali su da je značajno više bolesnika sa T4 stadijumom registrovano u toku pandemije; pritom, u većini slučajeva radilo se o karcinomu mokraćne bešike.
Reference
Barbos V, Feciche B, Bratosin F, Bogdan I, Negrean RA, Latcu S, et al. A Retrospective Analysis of the Challenges of Urothelial Cancer Management during the COVID-19 Pandemic at a Single Academic Center in Romania. Healthcare (Basel) 2023;11(6):812. [CrossRef] [PubMed]
Brument M, Pfister C, Cornu JN. Differential Impact of COVID-19 on Urological Surgeries in Public and Private Institutions at a Nationwide Level: Towards the Day of Reckoning. Eur Urol 2022;81(4):435-6. [CrossRef] [PubMed]
Chow WH, Devesa SS. Contemporary epidemiology of renal cell cancer. Cancer J 2008; 14(5):288-301. [CrossRef] [PubMed]
Cvetkovic VM, Nikolic N, Radovanovic Nenadic U, Öcal A, K Noji E, Zecevic M. Preparedness and Preventive Behaviors for a Pandemic Disaster Caused by COVID-19 in Serbia. Int J Environ Res Public Health 2020;17(11):4124. [CrossRef] [PubMed]
Detti B, Ingrosso G, Becherini C, Lancia A, Olmetto E, Alì E, et al. Management of prostate cancer radiotherapy during the COVID-19 pandemic: A necessary paradigm change. Cancer Treat Res Commun 2021;27:100331. [CrossRef] [PubMed]
Epstein MM, Sundaresan D, Fair M, Fouayzi H, Warner ET, Garber LD et al. Trends in breast and prostate cancer screening and diagnostic procedures during the COVID-19 pandemic in central Massachusetts. Cancer Causes Control 2022;33(10):1313-23. [CrossRef] [PubMed]
Gertz AH, Pollack CC, Schultheiss MD, Brownstein JS. Delayed medical care and underlying health in the United States during the COVID-19 pandemic: A cross-sectional study. Prev Med Rep 2022;28:101882. [CrossRef] [PubMed]
Goulabchand R, Claret PG, Lattuca B. What if the worst consequences of COVID-19 concerned non-COVID patients? J Infect Public Health 2020;13(9):1237-9. [CrossRef] [PubMed]
Guan WJ, Ni ZY, Hu Y, Liang WH, OU CQ, He JX. Clinical characteristics of Coronavirus disease 2019 in China. N Engl J Med 2020;382:1708–20. [CrossRef] [PubMed]
Guerrieri R, Rovati L, Dell'Oglio P, Galfano A, Ragazzoni L, Aseni P. Impact of the COVID-19 Pandemic on Urologic Oncology Surgery: Implications for Moving Forward. J Clin Med 2021;11(1):171. [CrossRef] [PubMed]
Heinze A, Umari P, Basulto-Martínez M, Suárez-Ibarrola R, Liatsikos E, Rassweiler J, et al. Impact of COVID-19 on Clinical and Academic Urological Practice: A Survey from European Association of Urology Section of Uro-technology. Eur Urol Open Sci 2020;21:22-8. [CrossRef] [PubMed]
Heldwein FL, Loeb S, Wroclawski ML, Sridhar AN, Carneiro A, Lima FS, et al. A Systematic Review on Guidelines and Recommendations for Urology Standard of Care During the COVID-19 Pandemic. Eur Urol Focus 2020;6(5):1070-85. [CrossRef] [PubMed]
Kalemci S, Ergun KE, Akyol A, Kizilay F. How Does the COVID-19 Pandemic Influence Histopathological Outcomes for Urologic Cancers? Cureus 2022;14(7):e26500. [CrossRef] [PubMed]
Li Z, Jiang Y, Yu Y, Kang Q. Effect of COVID-19 Pandemic on Diagnosis and Treatment Delays in Urological Disease: Single-Institution Experience. Risk Manag Healthc Policy 2021;14:895-900. [CrossRef] [PubMed]
Mangone L, Marinelli F, Bonfante G, Bisceglia I, Morabito F, Masini C, et al. The Impact of COVID-19 on New Kidney Cancer Diagnosis: Stage and Treatment in Northern Italy. Int J Environ Res Public Health 2023;20(6):4755. [CrossRef] [PubMed]
Mostafavi Zadeh SM, Tajik F, Moradi Y, Kiani J, Ghods R, Madjd Z. Impact of COVID-19 pandemic on screening and diagnosis of patients with prostate cancer: a systematic review protocol. BMJ Open 2022;12(8):e063748. [CrossRef] [PubMed]
Sanchez-Ortiz RF, Huang WC, Mick R, Van Arsdalen KN, Wein AJ, Malkowicz SB. An interval longer than 12 weeks between the diagnosis of muscle invasion and cystectomy is associated with worse outcome in bladder carcinoma. J Urol 2003;169(1):110–5. [CrossRef] [PubMed]
Shukla P, Lee M, Whitman SA, Pine KH. Delay of routine health care during the COVID-19 pandemic: A theoretical model of individuals' risk assessment and decision making. Soc Sci Med 2022;307:115164. [CrossRef] [PubMed]
Taheri D, Jahanshahi F, Khajavi A, Kafi F, Pouramini A, Farsani RM et al. The Impact of Covid-19 Pandemic on Genitourinary Cancers Stage and Grade. Clin Genitourin Cancer 2023;21(1):84-90. [CrossRef] [PubMed]
Travassos TC, De Oliveira JMI, Selegatto IB, Reis LO. COVID-19 impact on bladder cancer-orientations for diagnosing, decision making, and treatment. Am J Clin Exp Urol. 2021;9(1):132-9. [PubMed]
Tsuruta K, Majima T, Nishikimi T, Kashima A, Soeda Y, Inoue S et al. Impact of the coronavirus disease 2019 pandemic on the number of undergoing radical nephroureterectomy and postoperative adjuvant systematic therapy for upper tract urothelial carcinomas in Japan: A multicenter retrospective study. Int J Urol 2023; 30(5): 464-71. [CrossRef] [PubMed]
Wang X, Zhou Y, Liu L, Ma J, Wu H, Zhao L, et al. Coronavirus disease 2019 (COVID-19): diagnosis and prognosis. Blood Genom 2020; 4(2): 96-107. [CrossRef] [PubMed]
Worldometers.info. Serbia COVID – Coronavirus Statistics [Internet]. Dover, Delaware, U.S.A: c2023 [updated 2023 May; cited 2023 May 01]. Available from: https://www.worldometers.info/coronavirus/country/serbia/
