FAKTORI RIZIKA ZA NASTANAK FANTOMSKOG BOLA KOD PACIJENATA NAKON AMPUTACIJE DONJIH EKSTREMITETA
Sažetak
Fantomski bol je česta i kompleksna komplikacijakoja se može javiti nakon amputacije ekstremiteta. S obzirom na to da su postojeće farmakološke, psihološke i rehabilitacione metode samo delimično efikasne u prevazilaženju kod problema, postoji potreba za dodatnim istraživanjima. Cilj ovog rada bilo je ispitivanje faktora rizika povezanih s pojavom fantomskog bola kod pacijenata kojima je obavljena amputacija donjih ekstremiteta. Studija preseka je sprovedena u Centru za fizikalnu medicinu i rehabilitaciju Univerzitetskog kliničkog centra Vojvodine. U studiju su bila uključena 53 pacijenta (39 muškaraca, 14 žena) podvrnuta amputaciji donjih ekstremiteta ispod kolena (22) i iznad kolena (31), u pretprotetičkoj i protetičkoj fazi rehabilitacije. Podaci su sakupljeni uvidom u medicinsku dokumentaciju i kliničkim pregledom pacijenata. Fantomski bol je zabeležen kod 16 (30,18%) pacijenata. Ustanovljena je statistički značajna povezanost između pojave fantomskog bola i nivoa amputacije (p = 0,046), kao i između pojave fantomskog bola i faze rehabilitacije (p = 0,011). Nivo amputacije i faza rehabilitacije predstavljaju statistički značajne faktore rizika za razvoj fantomskog bola.
Reference
Ahuja V, Thapa D, Ghai B. Strategies for prevention of lower limb post-amputation pain: A clinical narrative review. J Anaesthesiol Pharmacol 2018; 34(4):439-49. [CrossRef] [PubMed]
Bekrater-Bodmann R, Reinhard I, Diers M, Fuchs X, Flor H. Relationship of prosthesis ownership and phantom limb pain: results of a survey in 2383 limb amputees. Pain 2021; 162(2):630-40. [CrossRef] [PubMed]
Collins KL, Russell HG, Schumacher PJ, Robinson-Freeman KE, O’Conor EC, Gibney KD, et al. A review of current theories and treatments for phantom limb pain. J Clin Inv 2018; 128(6):2168-76. [CrossRef] [PubMed]
Diers M, Krumm B, Fuchs X, Bekrater-Bodmann R, Milde C, Trojan J, et al. The prevalence and characteristics of phantom limb pain and non-painful phantom phenomena in a nationwide survey of 3,374 unilateral limb amputees. J Pain 2022; 23(3):411-23. [CrossRef] [PubMed]
Hsu E, Cohen SP. Postamputation pain: epidemiology, mechanisms, and treatment. J Pain Res 2013; 6: 121-36. [CrossRef] [PubMed]
Hubbard G, McNinch N, Tullington J, Merino K, Nerad R, Adams D, et al. Factors associated with phantom limb pain. JVS-VI 2023; 1:100018. [CrossRef]
Huo X, Huang P, Di H, Ma T, Jiang S, Yao J, et al. Risk factors analysis of phantom limb pain in amputees with malignant tumors. J Pain Res 2023;16:3979-92. [CrossRef] [PubMed]
Ishigami S, Boctor C. Epidemiology and risk factors for phantom limb pain. Front Pain Res. 2024; 5:1425544. [CrossRef] [PubMed]
Jiang S, Zheng K, Wang W, Pei Y, Qiu E, Zhu G. Phantom limb pain and sensations in Chinese malignant tumor amputees: a retrospective epidemiological study. Neuropsych Dis Treat 2021;17:1579-87. [CrossRef] [PubMed]
Kulkarni PG, Paudel N, Magar S, Santilli MF, Kashyap S, Baranwal AK, et al. Overcoming challenges and innovations in orthopedic prosthesis design: an interdisciplinary perspective. Biomed Mater Devices 2024; 2(1):58-69. [CrossRef] [PubMed]
Lans J, Groot OQ, Hazewinkel MH, Kaiser PB, Lozano-Calderón SA, Heng M, et al. Factors related to neuropathic pain following lower extremity amputation. Plast Reconst Surg 2022; 150(2):446-55. [CrossRef] [PubMed]
Limakatso K, Bedwell GJ, Madden VJ, Parker R. The prevalence and risk factors for phantom limb pain in people with amputations: a systematic review and meta-analysis. PloS one 2020; 15(10):e0240431. [CrossRef] [PubMed]
Limakatso K, Ndhlovu F, Usenbo A, Rayamajhi S, Kloppers C, Parker R. The prevalence and risk factors for phantom limb pain: a cross-sectional survey. BMC Neurol 2024; 24(1):57. [CrossRef] [PubMed]
Mogil JS. Sex differences in pain and pain inhibition: multiple explanations of a controversial phenomenon. Nat Rev Neurosci 2012; 13(12):859-66. [CrossRef] [PubMed]
Münger M, Pinto CB, Pacheco‐Barrios K, Duarte D, Enes Gunduz M, Simis M, et al. Protective and risk factors for phantom limb pain and residual limb pain severity. Pain Pract 2020; 20(6):578-87. [CrossRef] [PubMed]
Nees TA, Matt C, Deisenhofer J, Block J, Wolf SI, Renkawitz T, et al. Pain after lower limb amputations: insights from the Heidelberg Amputation Registry. Medicina (Kaunas) 2024; 60(11):1887. [CrossRef] [PubMed]
Noguchi S, Saito J, Nakai K, Kitayama M, Hirota K. Factors affecting phantom limb pain in patients undergoing amputation: retrospective study. J Anesthes 2019; 33(2):216-20. [CrossRef] [PubMed]
Shi W, Prabhakaran B, Annaswamy T. Phantom pain: mechanisms and updates in management. Front Pain Res 2025; 6:1567956. [CrossRef] [PubMed]
Stankevicius A, Wallwork SB, Summers SJ, Hordacre B, Stanton TR. Prevalence and incidence of phantom limb pain, phantom limb sensations and telescoping in amputees: a systematic rapid review. Euro J Pain 2021; 25(1):23-38. [CrossRef] [PubMed]
Streit F, Bekrater-Bodmann R, Diers M, Reinhard I, Frank J, Wüst S, et al. Concordance of phantom and residual limb pain phenotypes in double amputees: evidence for the contribution of distinct and common individual factors. J Pain 2015; 16(12):1377-85. [CrossRef] [PubMed]
Subedi B, Grossberg GT. Phantom limb pain: mechanisms and treatment approaches. Pain Res Manag 2011; 2011:864605. [CrossRef] [PubMed]
