Use of hyperthermal heating and intraoperatively administered applicator for the treatment of local malignant tumors

  • Ilya Vasilchenko Regional Clinical Oncological Dispensary, Volgogradskaya Street, 35, Kemerovo, 650036, Russia; Kemerovo State University, Krasnaya Street, 6, Kemerovo, 650000, Russia
  • Vladimir Braginsky Kemerovo State University, Krasnaya Street, 6, Kemerovo, 650000, Russia
  • Vitaly Rynk Kemerovo State University, Krasnaya Street, 6, Kemerovo, 650000, Russia
  • Aleksey Osintsev Kemerovo State University, Krasnaya Street, 6, Kemerovo, 650000, Russia
Keywords: laryngeal cancer, induction heating, polymer matrix, ferromagnetic filler, intraoperative non-contact hyperthermia

Abstract


Background: This article describes a method for non-contact local hyperthermal heating of patient's tissue using inductive electromagnetic radiation. Aim: The aim of the study was a theoretical and experimental assessment of the thermal and electromagnetic parameters of the proposed method based on heating of intraoperatively administered, personal, tissue-replacing applicator using induction magnetic field. Methods: Theoretical estimates of the thermal and electromagnetic parameters of this method were performed based on heat conduction equations. An experimental study of the process was carried out using originally designed laboratory inverter and confirmed theoretical calculations. Results: The performed assessments and calculations confirmed the possibility of creating clinically effective hyperthermia in the removed tumor bed by the method of local non-contact intraoperative hyperthermia. Conclusion: The proposed method can be used both independently and in combination with chemo- and radiotherapy, thus reducing the risk of recurrence for locally advanced forms of malignant tumors of the oropharyngeal region after surgical treatment.

References

Pankratov VA, Andreev VG, Mardynsky US, Rozhnov VA, Kurpeshev OK, Akki ED. Current approaches to conservative and combined treatment for locally advanced laryngeal cancer. Sibirskiy onkologicheskiy zhurnal 2013; 56(2): 36-40 (in Russian).

Rudolph E, Dyckhoff G, Becher H, Dietz A, Ramroth H. Effects of tumour stage, comorbidity and therapy on survival of laryngeal cancer patients: a systematic review and a meta-analysis. Eur Arch Otorhinolaryngol. 2011;268(2): 165-179.

Alferov VS. Organ-saving therapy of laryngeal cancer. In: Materials of IV Russian Oncology Conference. Moscow, Russia; 2009. p. 80–81 (in Russian).

Wilkie MD, Lightbody KA, Lythgoe D, Tandon S, Lancaster J, Jones TM. Transoral laser microsurgery for early and moderately advanced laryngeal cancers: outcomes from a single centralised United Kingdom centre. Eur Arch Otorhinolaryngol. 2015;272(3): 695-704.

Obinata K, Ohmori K, Shirato H, Nakamura M. Experience of high-dose-rate brachytherapy for head and neck cancer treated by a customized intraoral mold technique. Radiat Med. 2007; 25(4): 181-186.

Pankratov VA, Andreev VG. Local hyperthermia in stay-alone and preoperative chemio-radiation therapy of locally advanced laryngeal cancer. Sibirskiy onkologicheskiy zhurnal 2006; 1(add.): 77 (in Russian).

Chin RB, Stauffer, PR. Treatment planning for ferromagnetic seed heating. Int J Radiat Oncol Biol Phys. 1999; 21(2): 431-439.

Huang HS, Hainfeld JF. Intravenous magnetic nanoparticle cancer hyperthermia. Int J Nanomedicine 2013; 8: 2521-2532.

Wust P, Hildebrandt B, Sreenivasa G, Rau B, Gellermann J, Riess H, et al.Hyperthermia in combined treatment of cancer. Lancet Oncol. 2002 Aug;3(8):487-97.

Vasilchenko IL, Osintsev AM, Glushkov AN, Kolomiets SA, Polikarpov AF, Maitakov AL, et al. Sposob personalizirovannogo lecheniya mestnorasprostranennykh zlokachestvennykh novoobrazovanii na osnove lokalnoi kontaktnoi gipertermii s ispolzovaniem individualnogo tkaneekvivalentnogo applikatora (A method for personalized treatment of locally advanced malignant neoplasms based on local contact hyperthermia using an individual tissue-equivalent applicator). Invention patent RU 2565810. Russian Federation; 2015.

Vasilchenko IL, Osintsev AM, Kolomiets SA. Metod personalizirovannoi kontaktnoi gipertermii zlokachestvennykh opukholei na osnove induktsionnogo nagreva applikatora vikhrevymi tokami submegagertsovogo diapazona v sochetanii s kontaktnoi luchevoi terapiei (The method of personalized contact hyperthermia of malignant tumors based on induction heating of the applicator by eddy currents of the sub-MHz range in combination with contact radiation therapy). Meditsina v Kuzbasse 2015; 14(1): 21-26.

Vinogradov VM, Samsonova NN, Judin AL, Vasilchenko IL, Pastushenko DA. The first experience of contact intraoperative radiation therapy in the combined treatment of locally advanced laryngeal cancer. Voprosy onkologii 2011; 2: 232-235 (in Russian).

Osintsev AM, Maytakov AL, Vasilchenko IL, Vinogradov VM, Rynk VV. Method for local induction heating of biological tissues. Patent RU2497489. Russian Federation; 2013 (in Russian).

Smythe WR. Static and dynamic electricity. CRC Press; 1989. 623 p.

Qin S, Xu C, Li S, Wang X, Sun X, Wang P, et al. Hyperthermia induces apoptosis by targeting Survivin in esophageal cancer. Oncol Rep. 2015; 34(5): 2656-2664. https://doi.org/10.3892/or.2015.4252

Published
2022/02/09
Section
Original Scientific Paper