Distribution of histopathological types of thyroid tumors in 1999-2015 compared to 1966-1988 year period

Tanja Makazlieva; Olivija Vaskova; Aleksandra Nikolovska; Vesna Velikj Stefanovska

doi:10.2298/AOO190402005M

Tanja Makazlieva Institute of Pathophysiology and Nuclear Medicine, Medical Faculty University of "Ss. Cyril and Methodius",
Olivija Vaskova Institute of Pathophysiology and Nuclear Medicine, Medical Faculty University of "Ss. Cyril and Methodius",
Aleksandra Nikolovska Department of Oncology, Clinical hospital, Tetovo
Vesna Velikj Stefanovska Institute of Epidemiology and Biostatistics with Medical Informatics, Medical Faculty, University of "Ss. Cyril and Methodius",

DOI: https://doi.org/10.2298/AOO190402005M

Keywords: Thyroid carcinomas, Histopathological change, PTC/FTC ratio, Periodicity,

Abstract

Background: The most common thyroid tumors originate from the epithelial follicular cells. Etiology involved in the development of thyroid carcinoma is multifactorial, including external influences and genetic predisposition. Aim: The objective of our study was to analyze the distribution of the histopathological types of thyroid carcinoma during 1999-2015 year period, to evaluate papillary and follicular thyroid carcinoma ratio and to compare thyroid carcinoma types with the data from prior epidemiological study referring to the period from 1966 -1988. Methods: A retrospective analysis was performed. The trend for thyroid carcinoma cases was evaluated in the time period of 50 years. Percentages of different histopathological types of thyroid carcinoma were presented and papillary and follicular thyroid carcinoma ratio was calculated for the two evaluated periods. Results: A total number of 422 thyroid carcinoma patients were diagnosed in the 1999-2015 year period vs. 323 patients in the period from 1966-1988. Analysis revealed no statistically significant difference in histopathological types of thyroid carcinoma during 1999-2015 year period, but statistically significant difference was detected between the two analyzed periods with a significant increase of papillary and follicular thyroid carcinoma ratio (from 3.1 to 7.3), and a significant reduction of anaplastic thyroid carcinomas cases in the more recent evaluated period (1999-2015). Conclusion: The analysis of the fifty-year-period in population of North Macedonia showed an increase in number of thyroid carcinoma cases, especially papillary and reduction of follicular thyroid carcinoma and anaplastic thyroid carcinomas cases. Further, genetic profiling studies could be useful in evaluating possible mechanisms behind this shift in histopathology of the thyroid carcinomas.

Author Biographies

Tanja Makazlieva, Institute of Pathophysiology and Nuclear Medicine, Medical Faculty University of "Ss. Cyril and Methodius",

Nuclear Medicine, MD PhD

Olivija Vaskova, Institute of Pathophysiology and Nuclear Medicine, Medical Faculty University of "Ss. Cyril and Methodius",

Nuclear Medicine, Prof PhD

Aleksandra Nikolovska, Department of Oncology, Clinical hospital, Tetovo

Department of Oncology, MD

Vesna Velikj Stefanovska, Institute of Epidemiology and Biostatistics with Medical Informatics, Medical Faculty, University of "Ss. Cyril and Methodius",

Institute of Epidemiology and Biostatistics with Medical Informatics, Prof PhD

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