EXTRACT OF Morinda lucida LEAF RESCUES HYPOGLYCAEMIC AND DYSLIPIDAEMIC CONDITIONS IN Plasmodium berghei-INFECTED MICE

  • Adam Olaitan Abdulkareem Animal Physiology Unit, Department of Zoology, University of Ilorin, Ilorin, Nigeria; Pharmacology Division, CSIR-Central Drug Research Institute, Lucknow, India
  • Abdulkareem Olarewaju Babamale Parasitology Unit, Department of Zoology, University of Ilorin, Ilorin, Nigeria; Taiwan International Graduate Program in Molecular Medicine, National Yang-Ming Chiao Tung University and Academia Sinica, Taipei Taiwan
  • Abass Toba Anifowoshe Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, India; Department of Zoology, Faculty of Life Sciences, University of Ilorin, Ilorin, Nigeria
  • Olufunke Adenike Opeyemi Parasitology Unit, Department of Zoology, University of Ilorin, Ilorin, Nigeria
  • Nusirat Oloriegbe Animal Physiology Unit, Department of Zoology, University of Ilorin, Ilorin, Nigeria
  • Comfort Adamolekun Parasitology Unit, Department of Zoology, University of Ilorin, Ilorin, Nigeria
  • Samson Adetula Animal Physiology Unit, Department of Zoology, University of Ilorin, Ilorin, Nigeria
  • Adeola Adefoluke Ala Animal Physiology Unit, Department of Zoology, University of Ibadan, Ibadan, Nigeria
Keywords: Malaria, Hypoglycaemia, Dyslipidaemia, Morinda lucida, Plasmodium berghei

Abstract


Increasing drug resistance is a great threat to malaria control. Therefore, a continuous investigation into alternative therapy to mitigate malaria-associated damages is important. In this study, we investigated the anti-hypoglycaemic and anti-hyperlipidaemic effects of aqueous extract of Morinda lucida leaf in Plasmodium berghei­-infected mice. Twenty-five mice were randomly grouped into five: Uninfected, infected-untreated, chloroquine (20 mg/kg, per oral), and extract-treated (400 mg/kg and 800 mg/kg, respectively, per oral) groups. Fasting blood glucose was measured before parasite inoculation and after the last treatment. Blood was collected for lipid profile assay at the end of the 4-day treatment. Our results revealed that both chloroquine and the extract lowered parasite growth (p <0.05), while chloroquine and 400 mg/kg of the extract improved blood glucose in Plasmodium berghei-infection. More so, all the treated groups showed attenuated Plasmodium berghei-induced dyslipidaemia, with 400 mg/kg of the extract exhibiting better efficacy. Therefore, this study suggests that Morinda lucida leaf extract can be harnessed as a therapeutic regimen for improved malaria treatments and associated complications. Further study is recommended to elucidate the mechanism of anti-hypoglycaemic and anti-hyperlipidaemic activities of the extract and the possible bioactive compound(s) involved.

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Published
2022/09/11
Section
Original Scientific Paper