Intestinalne matične ćelije

Sanja B Bojić; Miodrag Stojković; Bojana Simović Marković; Ana Volarević

doi:10.5937/mckg47-3311

Sanja B Bojić Univerzitet u Kragujevcu, Fakultet medicinskih nauka, Katedra za genetiku
Miodrag Stojković Univerzitet u Kragujevcu, Fakultet medicinskih nauka, Katedra za genetiku
Bojana Simović Marković Univerzitet u Kragujevcu, Fakultet medicinskih nauka
Ana Volarević Univerzitet u Kragujevcu, Fakultet medicinskih nauka

DOI: https://doi.org/10.5937/mckg47-3311

Sažetak

Tkivo koje najbrže proliferiše u organizmu je epitel gastrointestinalnog trakta. Sve terminalno diferentovane ćelije intestinuma potiču od iste populacije multipotentnih ćelija koje se nalaze unutar intestinalnih kripti. U literaturi se pominju dva osnovna modela pozicije matičnih ćelija unutar intestinalnih kripti, model '' + 4 pozicije'' po kome se matične ćelije nalaze neposredno iznad Panetovih ćelija i model ''stem ćelijske zone'' po kome se matične ćelije nalaze između samih Panetovih ćelija dok ćelije iznad Panetovih predstavljaju njihove direktne potomke. Do sada je identifikovano više različitih markera intestinalnih matičnih ćelija ali ni jedan od njih nije specifičan isključivo za intestinalne matične ćelije što otežava njihovu identifikaciju i izolaciju. Svrha ovog članka je revizija dosadašnjih saznanja i literature o markerima, nišama, izolaciji i kultivaciji intestinalnih matičnih ćelija.

Biografije autora

Sanja B Bojić, Univerzitet u Kragujevcu, Fakultet medicinskih nauka, Katedra za genetiku

doktor medicine

Miodrag Stojković, Univerzitet u Kragujevcu, Fakultet medicinskih nauka, Katedra za genetiku

Prof. dr

Bojana Simović Marković, Univerzitet u Kragujevcu, Fakultet medicinskih nauka

doktor medicine

Ana Volarević, Univerzitet u Kragujevcu, Fakultet medicinskih nauka

dipl.psiholog

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