IRISIN AND INTERLEUKINS-33 AND -37 LEVELS IN PATIENTS WITH ISCHEMIC HEART DISEASE UNDER OBESITY INFLUENCE
IRISIN AND INTERLEUKINS-33 AND -37 AND ISCHEMIC HEART DISEASE
Ključne reči:
English
Sažetak
Cilj. Cilj ovog rada bio je istražiti uticaj gojaznosti na nivo irisina i interleukina 33 i 37 kod pacijenata sa koronarnom bolešću srca.
Metode. Prvu grupu je predstavljalo 36 pacijenata sa koronarnom arterijskom bolešću (KAB) i gojaznošću. Uporednu grupu činilo je 33 pacijenta sa koronarnom bolešću sa normalnom telesnom težinom. Kontrolnu grupu činilo je 30 praktično zdravih osoba. Nivo irisina i interleukina meren je ELISA testom. Gojaznost je naznačena kao povećan indeks telesne mase (BMI) ≥ 30 kg/m2.
Rezultati. Studija je pokazala da je irisin smanjen za 127,36 (107,52 - 137,88) ng / ml) u grupi sa stabilnom anginom pektoris u poređenju sa kontrolom 147,92 (139,04 - 172,55) ng / ml, p = 0,290. Pacijenti sa kombinovanom koronarnom arterijskom bolešću i gojaznošću imali su značajno povećan nivo IL-33 (123,56 ± 32,38 pg / ml, p = 0,004) i IL-37 (131,74 ± 24,17 pg / ml, p = 0,004). Multivarijantne regresione analize pokazale su da je BMI pozitivno korelirao sa irisinom u serumu kod gojaznih pacijenata sa KAB (β = 0,255, p = 0,039).
Zaključak. Koegzistencija gojaznosti kod pacijenata sa stabilnom anginom se smatra značajnim faktorom smanjenja irisina i povećanjem nivoa 33 i 37 interleukina. Indeks telesne mase imao je direktnu korelaciju sa koncentracijom irisina kod gojaznih pacijenata sa koronarnom bolešću.
Reference
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26. Liu R. and Nikolajczyk BS. Tissue Immune Cells Fuel Obesity-Associated Inflammation in Adipose Tissue and Beyond. Front Immunol 2019; 10:1587.
27. Hasan A, Al-Ghimlas F, Warsame S, et al. IL-33 is negatively associated with the BMI and confers a protective lipid/metabolic profile in non-diabetic but not diabetic subjects. BMC Immunol 2014; 15:19.
28. Zeyda M, Wernly B, Demyanets S, et al. Severe obesity increases adipose tissue expression of interleukin-33 and its receptor ST2, both predominantly detectable in endothelial cells of human adipose tissue. Int J Obes 2013; 37:658–65.
29. Demyanets S, Konya V, Kastl SP, et al. Interleukin-33 induces expression of adhesion molecules and inflammatory activation in human endothelial cells and in human atherosclerotic plaques. Arterioscler Thromb Vasc Biol 2011; 31:2080–89.
30. Chai M, Zhang HT, Zhou YJ, et al. Elevated IL-37 levels in the plasma of patients with severe coronary artery calcification. J Geriatr Cardiol 2017; 14(5):285–91.
31. Polyzos SA, Anastasilakis AD, Efstathiadou ZA, et al. Irisin in metabolic diseases. Endocrine 2018; 59(2):260-74.
32. Korta P, Pocheć E, Mazur-Biały A. Irisin as a Multifunctional Protein: Implications for Health and Certain Diseases. Medicina (Kaunas) 2019; 55(8):485.
2. Mohammed SE, Ismail P, Huzwah K, Asmah R, Yehia A. Obesity and inflammation:the linking mechanism and the complications. Arch Med Sci 2017; 13(4):851–63.
3. Rodríguez-Hernández H, Simental-Mendía LE, Rodríguez-Ramírez G, Reyes-Romero MA. Obesity and Inflammation:Epidemiology, Risk Factors, and Markers of Inflammation. Int J Endocrinol 2013; Article ID 678159.
4. Schwartz C, O’Grady K, Lavelle EC, Fallon PG. Interleukin 33:an innate alarm for adaptive responses beyond Th2 immunity-emerging roles in obesity, intestinal inflammation, and cancer. Eur J Immunol 2016; 46:1091–1100.
5. Boraschi D, Lucchesi D, Hainzl S, et al. IL-37:a new anti-inflammatory cytokine of the IL-1 family. Eur Cytokine Netw 2011; 22(3):127–47.
6. Briganti SI, Gaspa G, Tabacco G, et al. Irisin as a regulator of bone and glucose metabolism. Minerva Endocrinol 2018; 43(4):489-500.
7. Knuuti J, Wijns W, Saraste A, et al. ESC Scientific Document Group, 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes:The Task Force for the diagnosis and management of chronic coronary syndromes of the European Society of Cardiology (ESC). Eur Heart J 2020; 41(3):407–77.
8. Perakakis N, Triantafyllou GA, Fernández-Real JM, et al. Physiology and role of irisin in glucose homeostasis. Nat Rev Endocrinol 2017; 13(6):324-37.
9. Sahin-Efe A, Upadhyay J, Ko BJ, et al. Irisin and leptin concentrations in relation to obesity, and developing type 2 diabetes:a cross sectional and a prospective case-control study nested in the Normative Aging Study. Metabolism 2018; 79:24–32.
10. Yin C, Hu W, Wang M, Lv W, Jia T, Xiao Y. Irisin as a mediator between obesity and vascular inflammation in Chinese children and adolescents. Nutr Metab Cardiovasc Dis 2020; 30(2):320–29.
11. Löffler D, Müller U, Scheuermann K, et al. Serum irisin levels are regulated by acute strenuous exercise. J Clin Endocrinol Metab 2015; 100(4):1289–99.
12. Stengel A, Hofmann T, Goebel-Stengel M, Elbelt U, Kobelt P, Klapp BF. Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity–correlation with body mass index. Peptides 2013; 39:125–30.
13. Crujeiras AB, Pardo M, Arturo RR, et al. Longitudinal variation of circulating irisin after an energy restriction-induced weight loss and following weight regain in obese men and women. Am J Hum Biol 2014; 26(2):198–207.
14. Bonfante ILP, Chacon-Mikahil MPT, Brunelli DT, et al. Obese with higher FNDC5/Irisin levels have a better metabolic profile, lower lipopolysaccharide levels and type 2 diabetes risk. Arch Endocrinol Metab 2017; 61(6):524–33.
15. Shim YS, Kang MJ, Yang S, Hwang IT. Irisin is a biomarker for metabolic syndrome in prepubertal children. Endocr J 2018; 65(1):23–31.
16. Liu BW, Yin FZ, Qi XM, Fan DM, Zhang Y. The levels of serum irisin as a predictor of insulin resistance in han chinese adults with metabolically healthy obesity. Clin Lab 2017; 63(5):881–86.
17. Jia J, Yu F, Wei WP, et al. Relationship between circulating irisin levels and overweight/obesity:A meta-analysis. World J Clin Cases 2019; 7(12):1444-55.
18. Fukushima Y, Kurose S, Shinno H, et al. Effects of Body Weight Reduction on Serum Irisin and Metabolic Parameters in Obese Subjects. Diabetes Metab J 2016; 40(5):386-95.
19. Elizondo-Montemayor L, Gonzalez-Gil AM, Tamez-Rivera O, et al. Association between Irisin, hs-CRP, and Metabolic Status in Children and Adolescents with Type 2 Diabetes Mellitus. Mediators Inflamm 2019; 2019:6737318.
20. Eslampour E, Ebrahimzadeh F, Abbasnezhad A, Khosroshahi MZ, Choghakhori R, Asbaghi O. Association between Circulating Irisin and C-Reactive Protein Levels:A Systematic Review and Meta-Analysis. Endocrinol Metab (Seoul) 2019; 34(2):140-49.
22. Altara R, Giordano M, Norden ES, et al. Targeting obesity and diabetes to treat heart failure with preserved ejection fraction. Front Endocrinol 2017; 8:160.
22. Wensveen FM, Valentić S, Šestan M, Turk Wensveen T, Polić B. Polic B. The “Big Bang” in obese fat:events initiating obesity-induced adipose tissue inflammation. Eur J Immunol 2015; 45:2446–56.
23. Helmersson-Karlqvist J, Björklund-Bodegård K, Larsson А, Basu S. 24-Hour ambulatory blood pressure associates inversely with prostaglandin F (2α), interleukin-6 and F(2)-isoprostane formation in a Swedish population of older men. Int. J. Clin. Exp. Med 2012; 5(2):145-53.
24. Thomas D. and Apovian C. Macrophage functions in lean and obese adipose tissue. Metabolism 2017; 72:120-43.
25. Pirola L. and Ferraz JC. Role of pro- and anti-inflammatory phenomena in the physiopathology of type 2 diabetes and obesity. World J Biol Chem 2017; 8(2):120-28.
26. Liu R. and Nikolajczyk BS. Tissue Immune Cells Fuel Obesity-Associated Inflammation in Adipose Tissue and Beyond. Front Immunol 2019; 10:1587.
27. Hasan A, Al-Ghimlas F, Warsame S, et al. IL-33 is negatively associated with the BMI and confers a protective lipid/metabolic profile in non-diabetic but not diabetic subjects. BMC Immunol 2014; 15:19.
28. Zeyda M, Wernly B, Demyanets S, et al. Severe obesity increases adipose tissue expression of interleukin-33 and its receptor ST2, both predominantly detectable in endothelial cells of human adipose tissue. Int J Obes 2013; 37:658–65.
29. Demyanets S, Konya V, Kastl SP, et al. Interleukin-33 induces expression of adhesion molecules and inflammatory activation in human endothelial cells and in human atherosclerotic plaques. Arterioscler Thromb Vasc Biol 2011; 31:2080–89.
30. Chai M, Zhang HT, Zhou YJ, et al. Elevated IL-37 levels in the plasma of patients with severe coronary artery calcification. J Geriatr Cardiol 2017; 14(5):285–91.
31. Polyzos SA, Anastasilakis AD, Efstathiadou ZA, et al. Irisin in metabolic diseases. Endocrine 2018; 59(2):260-74.
32. Korta P, Pocheć E, Mazur-Biały A. Irisin as a Multifunctional Protein: Implications for Health and Certain Diseases. Medicina (Kaunas) 2019; 55(8):485.
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2022/03/07
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