https://aseestant.ceon.rs/index.php/medi/issue/feed
Medicinska istraživanja
2024-11-20T08:29:37+01:00
Prof. dr Olivera Stanojlović
ostanoj@gmail.com
SCIndeks Assistant
<p>Medicinska istraživanja“ je recenzirani naučni časopis Medicinskog fakulteta Univerziteta u Beogradu, koji je prvi put objavljen 1971 godine, dakle, pre pola veka. Časopis „Medicinska istraživanja“ je prvenstveno posvećen publikovanju rezultata naučno-istraživačkog rada nastavnika i saradnika Medicinskog fakulteta, kao i drugih naučnika u oblasti biomedicinskih istraživanja. Časopis „Medicinska istraživanja“ objavljuje naučne radove na engleskom jeziku uz sažetak na srpskom jeziku i ima usvojenu politiku otvorenog pristupa (open access). Izlazi tri puta godišnje, dok se u četvrtoj svesci objavljuju i sažeci izlaganja na simpozijumu „Stremljenja i novine u medicini“. U časopisu „Medicinska istraživanja“ se objavljuju originalni i prethodno neobjavljeni radovi: a. originalni radovi u kojima se prvi put objavljuju rezultati sopstvenih istraživanja; b. pregledni radovi (Review), kritički i originalno prikazani (sa autocitatima); c. prikazi bolesnika i slučajeva (Case report). Radovi koji se objavljuju u časopisu „Medicinska istraživanja“ pripadaju oblastima: bazičnih biomedicinskih istraživanja, kliničkih istraživanja i preventivne medicine. U cilju stručne recenzije prispelih radova, Uređivački odbor časopisa je podeljen u tri sekcije: bazične, kliničke i preventivne nauke, a njihovim radom koordiniraju Urednici sekcija. Sekcija za statističku analizu podataka će biti uključena u evaluaciju statističkih podataka prispelih radova.</p>
https://aseestant.ceon.rs/index.php/medi/article/view/53710
Hirurška zamena aortne valvule istog dana nakon stentiranja karotidne arterije- manje invazivna procedura za visoko-rizične pacijente
2024-11-20T08:29:30+01:00
Slobodan Mićović
bobanmic@gmail.com
Zoran Tabaković
zokitaba@gmail.com
Ivan Soldatović
soldatovicivan@gmail.com
Petar Vuković
petarvuk02@gmail.com
Petar Milačić
petar_milacic@yahoo.com
Ivana Petrović
petrovicivana4@gmail.com
Miloš Matković
dr.matko@hotmail.com
Stefan Grujić
drstefangrujic@gmail.com
Igor Živkovic
igor88zivkovic@gmail.com
<p class="MsoNormal" style="text-align: justify; text-indent: 36.0pt; line-height: 200%;"><a name="_Hlk149509019"></a><strong><span style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif; color: black; mso-themecolor: text1; mso-ansi-language: SR-LATN-RS;">Uvod:</span></strong><span style="mso-bookmark: _Hlk149509019;"><span style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif; color: black; mso-themecolor: text1; mso-ansi-language: SR-LATN-RS;"> Etiologija stenoze aortne valvule (SOAS) je multifaktorijalna; hipertenzija, hiperlipidemija i dijabetes melitus su najčešći faktori rizika za nastanak ovog oboljenja. Ovi faktori rizika povećavaju i učestalost ateroskleroze u perifernim arterijskim krvnim sudovima. Hemodinamski poremećaj kod oba oboljenja povećava rizik od cerebrovaskularnih događaja. Zbog preklapanja simptoma kod pacijenata sa udruženom stenozom aortne valvule i karotidnom bolešću, nije lako doneti odluku o indikaciji za adekvatnim tretmanom. Postoji nekoliko strategija lečenja: hibridna procedura, simultana hirurgija, etapna procedura, transkateterska tehnika ili medikamentozno lečenje.</span></span></p> <p class="MsoNormal" style="text-align: justify; text-indent: 36.0pt; line-height: 200%;"><span style="mso-bookmark: _Hlk149509019;"><strong><span lang="EN-US" style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif; color: black; mso-themecolor: text1;">Cilj:</span></strong></span><span style="mso-bookmark: _Hlk149509019;"><span lang="EN-US" style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif; color: black; mso-themecolor: text1;"> Cilj studije je ispitivanje izvodljivosti i sigurnosti hibridne procedure SAVR i CAS kod pacijenata sa udruženom aortnom stenozom i stenozom karotidnih arterija. </span></span></p> <p class="MsoNormal" style="text-align: justify; text-indent: 36.0pt; line-height: 200%;"><span style="mso-bookmark: _Hlk149509019;"><strong><span lang="EN-US" style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif; color: black; mso-themecolor: text1;">Materijal i metode:</span></strong></span><span style="mso-bookmark: _Hlk149509019;"><span lang="EN-US" style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif; color: black; mso-themecolor: text1;"> Prospektivna nerandomizovana studija je izvedena na našem Institutu od avgusta 2015. do avgusta 2023. godine i pacijenti su bili podvrgnuti hibridnoj procedure (istog dana je urađena hirurgija aortne valvule i implantacija stenta u karotidnoj arteriji).</span></span></p> <p class="MsoNormal" style="text-align: justify; text-indent: 36.0pt; line-height: 200%;"><span style="mso-bookmark: _Hlk149509019;"><strong><span lang="EN-US" style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif; color: black; mso-themecolor: text1;">Rezultati: </span></strong></span><span style="mso-bookmark: _Hlk149509019;"><span lang="EN-US" style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif; color: black; mso-themecolor: text1;">Studijom je obuhvaćeno 34 pacijenta sa udruženom karotidnom bolešću i stenozom aortne valvule. Osim <span style="mso-spacerun: yes;"> </span>same hirurgije aortne valvule, u najvećem broju slučajeva pacijentima je rađena i konkomitantna hirurška revaskularizacija miokarda. Ukupno su evidentirana 3 neželjenja kardiovaskularna događaja. </span></span></p> <p class="MsoNormal" style="text-align: justify; text-indent: 36.0pt; line-height: 200%;"><span style="mso-bookmark: _Hlk149509019;"><strong><span lang="EN-US" style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif; color: black; mso-themecolor: text1;">Zaključak:</span></strong></span><span style="mso-bookmark: _Hlk149509019;"><span lang="EN-US" style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif; color: black; mso-themecolor: text1;"> Nema mnogo istraživanja na ovu temu, te nema jasnih preporuka o strategiji lečenja. Simultano hirurško lečenje aortne valvule i karotidne arterije se izvodi uz prihvatljivo dobre rezultate, ali može biti previse invazivno za visoko-rizične pacijente. U tom slučaju treba razmotriti hiruršku zamenu aortnog zaliska <span style="mso-spacerun: yes;"> </span>i CAS kao manje invazivnu opciju lečenja. </span></span></p>
2024-10-10T00:00:00+02:00
Sva prava zadržana (c) 2024 Medicinska istraživanja
https://aseestant.ceon.rs/index.php/medi/article/view/51138
Zapaljenske manifestacije infekcije virusima Herpesviridae na prednjem segmentu oka
2024-11-20T08:29:31+01:00
Aleksandra Radosavljevic
alexandra.radosavljevic@gmail.com
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Name="List Table 7 Colorful Accent 6"/> </w:LatentStyles> </xml><![endif]--><!-- [if gte mso 10]> <style> /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin-top:0in; mso-para-margin-right:0in; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0in; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri",sans-serif; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} </style> <![endif]--></p> <p class="MsoNormal" style="margin-bottom: .0001pt; text-align: justify; text-justify: inter-ideograph; line-height: 150%;"><strong><span style="font-size: 12.0pt; line-height: 150%; font-family: 'Times New Roman',serif;">Uvod: </span></strong><em style="mso-bidi-font-style: normal;"><span style="font-size: 12.0pt; line-height: 150%; font-family: 'Times New Roman',serif; mso-bidi-font-weight: bold;">Herpesviridae</span></em><span style="font-size: 12.0pt; line-height: 150%; font-family: 'Times New Roman',serif; mso-bidi-font-weight: bold;"> predstvaljaju veliku familiju dvolančanih DNK virusa od kojih osam tipova </span><span style="font-size: 12.0pt; line-height: 150%; font-family: 'Times New Roman',serif;">inficira ljude: Herpes simplex virus (HSV) tip 1 i 2, Varicella zoster virus (VZV), Cytomegalovirus (CMV), Epstein Barr virus (EBV), Human herpesvirus (HHV) 6, 7 i 8. <span style="mso-bidi-font-weight: bold;">Herpetična bolest oka može zahvatiti prednji i/ili zadnji segment oka. U ovom radu biće prikazane manifestacije na prednjem segment oka.</span></span></p> <p class="MsoNormal" style="margin-bottom: .0001pt; text-align: justify; text-justify: inter-ideograph; line-height: 150%;"><strong><span style="font-size: 12.0pt; line-height: 150%; font-family: 'Times New Roman',serif;">Metodologija: </span></strong><span style="font-size: 12.0pt; line-height: 150%; font-family: 'Times New Roman',serif; mso-bidi-font-weight: bold;">U revijskom radu su analizirani naučni radovi publikovanim u PubMed databazi do 30.4.2024. sa ključnim rečima: scleritis, keratitis, anterior uveitis, herpetic, HSV, VZV, CMV, EBV. </span></p> <p class="MsoNormal" style="margin-bottom: .0001pt; text-align: justify; text-justify: inter-ideograph; line-height: 150%;"><strong><span style="font-size: 12.0pt; line-height: 150%; font-family: 'Times New Roman',serif;">Rezultati: </span></strong><span style="font-size: 12.0pt; line-height: 150%; font-family: 'Times New Roman',serif; mso-bidi-font-weight: bold;">Dobro je poznato da HSV1, VZV i CMV uzrokuju inflamaciju prednjeg segmenta oka<strong>, </strong>i to skleritis, keratitis i prednji uveitis ili njihovu kombinaciju. Ipak, postoje prikazi slučajeva uzrokovanih EBV, HSV2 ili HHV6. Bolest obično ima hronični ili recidivirajući tok i dugotrajna inflamacija može uzrokovati ozbiljna oštećenja tkiva oka, koja mogu značajno oštetiti vid. Iako neki tipovi zapaljenja oka se mogu efikasno lečiti antivirusnim lekovima tokom aktivne faze bolesti (npr. HSV1, HSV2, VZV, CMV), za sada nema finalnog rešenja koje bi trajno sprečilo recidive bolesti. Glavne komplikacije uključuju ožiljke rožnjače, istanjenje sklere, glaukom, sinehije, atrofiju dužice i katarakta.</span></p> <p class="MsoNormal" style="margin-bottom: .0001pt; text-align: justify; text-justify: inter-ideograph; line-height: 150%;"><strong style="mso-bidi-font-weight: normal;"><span style="font-size: 12.0pt; line-height: 150%; font-family: 'Times New Roman',serif;">Zaključak</span></strong><span style="font-size: 12.0pt; line-height: 150%; font-family: 'Times New Roman',serif;">: Usled hroničnog i recidivirajućeg toka bolesti, herpetične zapajenske manifestacije prednjeg segmenta oka još uvek predstavljaju izazov za kliničara. Iako u nekim slučajevima postoje tipični klinički znaci koji vode oftalmologa da posumnja na herpetični izrok zapaljenja, finalna dijagnoza (posebno u atipičnim slučajevima) se može doneti jedino potvrdom virusne DNK iz tkiva oka pomoću PCR metode ili u slučajevima uveitisa detekcijom lokalne produkcije specifičnih antivirusnih antitela u očnoj vodici pomoću Goldmann-Witmer-ovog koeficijenta </span></p>
2024-10-14T10:04:41+02:00
Sva prava zadržana (c) 2024 Medicinska istraživanja
https://aseestant.ceon.rs/index.php/medi/article/view/51060
Stres kod trudnica tokom pandemije COVID-19 pandemije
2024-11-20T08:29:31+01:00
Konstantin Kostić
k.ginekos@gmail.com
Aleksandra Kostić
a.ginekos@gmail.com
Nikolina Banjanin
nikolina.banjanin85@gmail.com
Jelena Milin-Lazović
milinjelena@gmail.com
<p class="MsoNormal" style="margin-bottom: .0001pt; line-height: 200%;"><strong><span lang="EN-US" style="font-size: 12.0pt; mso-bidi-font-size: 11.0pt; line-height: 200%; font-family: 'Times New Roman',serif;">Uvod:</span></strong><span lang="EN-US" style="font-size: 12.0pt; mso-bidi-font-size: 11.0pt; line-height: 200%; font-family: 'Times New Roman',serif;"> Trudnoća je osetljiv period u životu žene kada psihološki distres može imati negativne posledice po majku i plod. Trudnice i porodilje su pod povećanim rizikom za oboljevanje težom kliničkom slikom od COVID-19 infekcije u poređenju sa ženama koje nisu trudne.</span></p> <p class="MsoNormal" style="margin-bottom: .0001pt; line-height: 200%;"><strong><span lang="EN-US" style="font-size: 12.0pt; mso-bidi-font-size: 11.0pt; line-height: 200%; font-family: 'Times New Roman',serif;">Cilj rada:</span></strong><span lang="EN-US" style="font-size: 12.0pt; mso-bidi-font-size: 11.0pt; line-height: 200%; font-family: 'Times New Roman',serif;"> Ispitivanje stresa kod trudnica u Srbiji tokom COVID-19 pandemije.</span></p> <p class="MsoNormal" style="margin-bottom: .0001pt; line-height: 200%;"><strong><span lang="EN-US" style="font-size: 12.0pt; mso-bidi-font-size: 11.0pt; line-height: 200%; font-family: 'Times New Roman',serif;">Materijal i metode:</span></strong><span lang="EN-US" style="font-size: 12.0pt; mso-bidi-font-size: 11.0pt; line-height: 200%; font-family: 'Times New Roman',serif;"> Anonimni upitnik dat je na popunjavanje trudnicama prilikom ambulantnog pregleda. Ispitivane su socijalno-demografske karakteristike, akušerski faktori, COVID-19 istorija, DASS-21 upitnik i PREPS upitnik.</span></p> <p class="MsoNormal" style="margin-bottom: .0001pt; line-height: 200%;"><strong><span lang="EN-US" style="font-size: 12.0pt; mso-bidi-font-size: 11.0pt; line-height: 200%; font-family: 'Times New Roman',serif;">Rezultati:</span></strong><span lang="EN-US" style="font-size: 12.0pt; mso-bidi-font-size: 11.0pt; line-height: 200%; font-family: 'Times New Roman',serif;"> U okviru PREPS upitnika, prosečna ocena za domen ,,pripremljenosti za porođaj“ je 2,4±0,9, za domen ,,infekcija“ 2,9±1,0, a za domen ,,pozitivno vrednovanje trudnoće“ 3,7±0,8. Pozitivna, slaba statistički značajna povezanost je registrovana između domena pripremljenost za porođaj sa domenima depresija i anksioznost na DASS-21 upitniku. Pozitivna, umerena statistički značajna povezanost je registrovana između domena pripremeljenost za porođaj sa domenom stres na DASS-21 upitniku. Pozitivna, slaba statistički značajna povezanost je registrovana između domena infekcija i stres na DASS-21 upitniku.</span></p> <p class="MsoNormal" style="margin-bottom: .0001pt; line-height: 200%;"><strong><span lang="EN-US" style="font-size: 12.0pt; mso-bidi-font-size: 11.0pt; line-height: 200%; font-family: 'Times New Roman',serif;">Zaključak:</span></strong><span lang="EN-US" style="font-size: 12.0pt; mso-bidi-font-size: 11.0pt; line-height: 200%; font-family: 'Times New Roman',serif;"> Dve godine od početka pandemije trudnice su preležale COVID-19 infekciju ili su vakcinisane, pa su dobijeni skorovi domena ,,pripremljenosti za porođaj“ i ,,infekcija“ očekivano niži, dok je skor za domen ,,pozitivno vrednovanje trudnoće“ viši u poređenju sa studijama koje su sprvedene na početku pandemije. Dobijeni rezultati osnažuju buduća istraživanja o povezanosti depresije, stresa i anksioznosti sa stresom u trudnoći prouzrokovanog COVID-19 pandemijom.</span></p> <p> </p> <p class="MsoNormal" style="margin-bottom: .0001pt; line-height: 200%;"><strong><span lang="EN-US" style="font-size: 10.0pt; mso-bidi-font-size: 11.0pt; line-height: 200%; font-family: 'Times New Roman',serif;">Ključne reči:</span></strong><span lang="EN-US" style="font-size: 10.0pt; mso-bidi-font-size: 11.0pt; line-height: 200%; font-family: 'Times New Roman',serif;"> <em>trudnoća, stres, COVID-19</em></span></p>
2024-10-14T10:07:17+02:00
Sva prava zadržana (c) 2024 Medicinska istraživanja
https://aseestant.ceon.rs/index.php/medi/article/view/51761
Grejvsova orbitopatija
2024-11-20T08:29:32+01:00
Biljana Beleslin
biljana_beleslin@yahoo.com
<p class="MsoNormal"><strong style="mso-bidi-font-weight: normal;"><span style="font-size: 12.0pt; line-height: 115%; font-family: 'Times New Roman',serif;">Sa</span></strong><strong style="mso-bidi-font-weight: normal;"><span lang="SR-LATN-RS" style="font-size: 12.0pt; line-height: 115%; font-family: 'Times New Roman',serif; mso-ansi-language: SR-LATN-RS;">žetak</span></strong></p> <p class="MsoNormal"><span lang="SR-LATN-RS" style="font-size: 12.0pt; line-height: 115%; font-family: 'Times New Roman',serif; mso-ansi-language: SR-LATN-RS;">Grejvsova orbitopatija (GO) je autoimino oboljenje orbite i glavna ekstratiroidna manifestacija Grejvsove bolesti. Oko 30% pacijenata sa <span style="mso-spacerun: yes;"> </span>Grejvsovom bolešću ima GO, dok manje od 10% razvije težu formu koja zahteva lečenje. Lečenje GO je multidisciplinarno. Izbor terapije se zasniva na proceni aktivnosti i težine bolesti Aktivnost predstavlja stepen inflamacije. Težina predstavlja stepen kozmetičkih i funkcionalnih poremećaja. Za blage i aktivne GO se savetuje kontrola faktora rizika, lokalna oftalmološka terapija i selen (posebno u oblastima deficitarnim selenom). Lečenje aktivnih srednje do teških formi GO u većini slučajeva se zasniva na primeni visokih doza<span style="mso-spacerun: yes;"> </span>intravenski primenjenih glukokortikoida kao monoterapijja ili u kombinaciji sa mikofenolatom. Druga linija lečenja obuhvata ponovljeni ciklus glukokortikoida intravenski, oralne glukokortikoide u kombinaciji sa ciklosporinom ili azatioprinn, radioterapiju u kombinaciji sa intravenskim glukokortikoidima, teprotumumab, rituksimab ili tocilizumab. U slučaju veoma teških, po vid ugrožavajućih GO se primenjuje više visokih, pojedinačnih<span style="mso-spacerun: yes;"> </span>doza metilprednizolona tokom nedelju dana. U slučaju da ne postoji povoljan odgovor na terapiju sprovodi se hitna hirurška dekompresija. Rekonstruktivna hirurgija (dekompresija, strabološka operacija ili operacija kapaka) je indikovana za neaktivne, posle medikamentne terapije zaostale, manifestacije GO. </span></p> <p class="MsoNormal"><strong style="mso-bidi-font-weight: normal;"><span lang="SR-LATN-RS" style="font-size: 12.0pt; line-height: 115%; font-family: 'Times New Roman',serif; mso-ansi-language: SR-LATN-RS;">Ključne reči: </span></strong><span lang="SR-LATN-RS" style="font-size: 12.0pt; line-height: 115%; font-family: 'Times New Roman',serif; mso-ansi-language: SR-LATN-RS;">Grejvsova orbitopatija, Grejvsova bolest, glukokortikoidi, mofetil, orbitalna dekompresija</span></p>
2024-10-14T10:18:23+02:00
Sva prava zadržana (c) 2024 Medicinska istraživanja
https://aseestant.ceon.rs/index.php/medi/article/view/52237
AKUTNA RADIJACIONA TOKSIČNOST KOD PACIJENATA SA GLIOBLASTOMOM KOJI SU LEČENI HIPOFRAKCIONISANOM RADIOTERAPIJOM
2024-11-20T08:29:32+01:00
Aleksandar Stepanović
a.stepanovic@ncrc.ac.rs
Tatjana Arsenijević
tatjanaarsenijevic96@gmail.com
Aleksandar Tomašević
alektom@gmail.com
Ivan Bogdanović
ivanbg83@gmail.com
Katarina Kopčalić
kaca.obradovic83@gmail.com
Bojana Poparić-Banđur
bojanapoparic@yahoo.com
Marina Nikitović
marina.nikitovic@ncrc.ac.rs
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Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Mention"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Smart Hyperlink"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Hashtag"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Unresolved Mention"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Smart Link"/> </w:LatentStyles> </xml><![endif]--><!-- [if gte mso 10]> <style> /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin-top:0cm; mso-para-margin-right:0cm; mso-para-margin-bottom:8.0pt; mso-para-margin-left:0cm; line-height:107%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Aptos",sans-serif; mso-ascii-font-family:Aptos; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Aptos; mso-hansi-theme-font:minor-latin; mso-font-kerning:1.0pt; mso-ligatures:standardcontextual; mso-fareast-language:EN-US;} </style> <![endif]--></p> <p class="MsoNormal" style="line-height: 250%;"><strong><span lang="SR-LATN-RS" style="font-size: 12.0pt; line-height: 250%; font-family: 'Times New Roman',serif; mso-ansi-language: SR-LATN-RS;">Uvod.</span></strong><span lang="SR-LATN-RS" style="font-size: 12.0pt; line-height: 250%; font-family: 'Times New Roman',serif; mso-ansi-language: SR-LATN-RS;"> Hipofrakcionisana radioterapija je preporučeni režim radioterapije za starije pacijente sa glioblastomom, kao i pacijente sa nepovoljnim prognostičkim faktorima. Pojava akutna radijacione toksičnosti je jedna od dilema kod primene hipofrakcionisanog režima radioterapije.</span></p> <p class="MsoNormal" style="line-height: 250%;"><strong><span lang="SR-LATN-RS" style="font-size: 12.0pt; line-height: 250%; font-family: 'Times New Roman',serif; mso-ansi-language: SR-LATN-RS;">Cilj</span></strong><span lang="SR-LATN-RS" style="font-size: 12.0pt; line-height: 250%; font-family: 'Times New Roman',serif; mso-ansi-language: SR-LATN-RS;">. Sproveli smo ovu retrospektivnu studiju sa ciljem da prikažemo profil akutne toksičnosti kod pacijenata sa glioblastomom lečenih hipofrakcionisanim režimom radioterapije, sa ili bez primene temozolomida. </span></p> <p class="MsoNormal" style="line-height: 250%;"><strong><span lang="SR-LATN-RS" style="font-size: 12.0pt; line-height: 250%; font-family: 'Times New Roman',serif; mso-ansi-language: SR-LATN-RS;">Materijal i metode</span></strong><span lang="SR-LATN-RS" style="font-size: 12.0pt; line-height: 250%; font-family: 'Times New Roman',serif; mso-ansi-language: SR-LATN-RS;">. Ova studija je obuhvatila 25 pacijenata sa dijagnostikovanim glioblastomom koji su bili lečeni hipofrakcionisanom radioterapijom, sa ukupnom dozom od 40 Gy u 15 frakcija ili 34 Gy u 10 frakcija. Akutna radijaciona toksičnost koja je zabeležena tokom tretmana, gradirana je prema <em>Common Terminology Criteria for Adverse Events, version 5.0.</em></span></p> <p class="MsoNormal" style="line-height: 250%;"><strong><span lang="SR-LATN-RS" style="font-size: 12.0pt; line-height: 250%; font-family: 'Times New Roman',serif; mso-ansi-language: SR-LATN-RS;">Rezultati</span></strong><span lang="SR-LATN-RS" style="font-size: 12.0pt; line-height: 250%; font-family: 'Times New Roman',serif; mso-ansi-language: SR-LATN-RS;">. Akutna radijaciona toksičnost je zabeležena kod 60% pacijenata. Većina pacijenata sa toksičnošću (80%) imala je gradus 1 toksičnosti. Jedan pacijent (6,7%) je imao radijacionu toksičnost gradusa 3. Nije zabeležena radijaciona toksičnost gradusa 4. Statistički značajno veći broj pacijenata koji su imali radiotoksičnost bili su raspoređeni u grupi pacijenata koji su imali tumor u više od jednog moždanog režnja, multifokalni ili multicentrični tumor, u poređenju sa pacijentima koji su imali tumor u jednom moždanom režnju (p < 0.01). </span></p> <p class="MsoNormal" style="line-height: 250%;"><strong><span lang="SR-LATN-RS" style="font-size: 12.0pt; line-height: 250%; font-family: 'Times New Roman',serif; mso-ansi-language: SR-LATN-RS;">Zaključci</span></strong><span lang="SR-LATN-RS" style="font-size: 12.0pt; line-height: 250%; font-family: 'Times New Roman',serif; mso-ansi-language: SR-LATN-RS;">. Hipofrakcionisani režim radioterapije predstavlja povoljnu opciju za lečenje starijih pacijenata sa glioblastomom ili onih pacijenata sa lošom prognozom, sa prihvatljivim profilom akutne radijacione toksičnosti. </span></p>
2024-10-14T10:20:37+02:00
Sva prava zadržana (c) 2024 Medicinska istraživanja
https://aseestant.ceon.rs/index.php/medi/article/view/52338
CAR indeks u predikciji mortaliteta hospitalizovanih pacijenata sa Kovid-19 pneumonijom
2024-11-20T08:29:32+01:00
Nataša Milić
silly_stat@yahoo.com
<p class="MsoNormal" style="text-align: justify; line-height: 200%;"><strong style="mso-bidi-font-weight: normal;"><span lang="EN-CA">Uvod/Cilj rada: </span></strong><span lang="EN-CA" style="mso-no-proof: yes;">Kovid-19 pneumonija je ozbiljan oblik bolesti koji može dovesti do teških komplikacija koje ugrožavaju život. Ova studija ima za cilj da proceni prognostičku vrednost CAR indeksa kod hospitalizovanih pacijenata sa kovid-19 pneumonijom. </span></p> <p class="MsoNormal" style="text-align: justify; line-height: 200%;"><strong style="mso-bidi-font-weight: normal;"><span lang="EN-CA">Metod: </span></strong><span lang="EN-CA">Istraživanje je sprovedeno kao prospektivna kohortna studija u Univerzitetskom kliničkom centru Zvezdara tokom aprila 2020. Godine. U studiju su uključeni pacijenati hospitalizovani zbog dijagnostikovane umerene do teške kovid-19 pneumonije. Kovid-19 infekcija je potvrđena reakcijom lančane polimeraze reverznom transkripcijom u realnom vremenu (RT-PCR) iz brisa nazofarinksa. CAR indeks je izračunat kao količnik CRP-a i albumina. </span></p> <p class="MsoNormal" style="text-align: justify; line-height: 200%;"><strong style="mso-bidi-font-weight: normal;"><span lang="EN-CA">Rezultati:</span></strong><span lang="EN-CA"> U studiju je uključeno 208 hospitalizovanih pacijenata sa Kovid-19 pneumonijom, prosečne starosti 54,5±14,6 godina, pretežno muškog pola (64,4%). Komorbiditeti su bili prisutni kod 67,3% pacijenata. Ukupan bolnički mortalitet iznosio je 14,4%. Vrednost CAR indeksa od 2,0 identifikovana je kao tačka preseka za predikciju mortaliteta, uz senzitivnost od 86% i specifičnost od 72% (AUC=0,844). U univarijantnoj regresionoj analizi, starost, komorbiditeti, otežano disanje i CAR indeks identifikovani su kao značajni prediktori mortaliteta (p<0,050, za sve analize). U multivarijantnoj analizi, starost (RR=1,06; 95% CI: 1,02-1,09; p=0,001) i CAR indeks (RR=1,12; 95% CI: 1,02-1,23; p=0,019) bili su nezavisni prediktori mortaliteta kod hospitalizovanih pacijenata sa Kovid-19 pneumonijom.</span></p> <p class="MsoNormal" style="text-align: justify; line-height: 200%;"><strong style="mso-bidi-font-weight: normal;"><span lang="EN-CA">Zaključak: </span></strong><span lang="EN-CA">Rutinska analiza krvi može biti korisna u identifikaciji pacijenata sa Kovid-19 pneumonijom koji su pod povećanim rizikom od letalnog ishoda. CAR indeks je široko dostupan, jednostavan inflamatorni marker koji može biti indikator za ranu diferencijaciju težine bolesti pacijenata sa Kovid-19 pneumonijom.</span></p>
2024-10-14T10:22:41+02:00
Sva prava zadržana (c) 2024 Medicinska istraživanja
https://aseestant.ceon.rs/index.php/medi/article/view/52718
KLINIČKE MANIFESTACIJE SINDROMA POLICISTIČNIH JAJNIKA
2024-11-20T08:29:33+01:00
Radmila M Sparic
radmila@rcub.bg.ac.rs
Jelena Zlatar
zlatarjelenamed@gmail.com
Luka Nikolić
luka.nikolic.med@gmail.com
Milica Opalić Palibrk
opalicmilica@gmail.com
Lena Radić
lena_radic@outlook.com
Jelica Bjekić Macut
jbjekic@yahoo.com
Sanja Ognjanović
ognjanovicsanja1@gmail.com
Djuro Macut
djmacut@gmail.com
<p class="MsoNormal" style="mso-margin-top-alt: auto; mso-margin-bottom-alt: auto; line-height: 200%;"><span style="font-family: 'Times New Roman',serif;">Sindrom policističnih jajnika, odnosno PCOS, kao najčešće endokrino oboljenje kod žena u reproduktivnom periodu predstavlja kompleksno oboljenje koje se karakteri</span><span lang="SR-LATN-RS" style="font-family: 'Times New Roman',serif; mso-ansi-language: SR-LATN-RS;">še različitim hormonskim poremećajima i brojnim varijacijama u kliničkoj slici.</span><span style="font-family: 'Times New Roman',serif;"> Dijagnoza i lečenje PCOS-a otežani su izrazito varijabilnom kliničkom slikom </span><span lang="SR-LATN-RS" style="font-family: 'Times New Roman',serif; mso-ansi-language: SR-LATN-RS;">i </span><span style="font-family: 'Times New Roman',serif;">nedovoljno poznatom etiologijom i patogenezom ovog poremećaja. Primarni klinički znaci PCOS-a obuhvataju hiperandrogenizam, ovlatornu disfunkciju i policističnu morfologiju jajnika, iako sva tri ne moraju biti prisutna kod svih pacijentkinja sa PCOS.</span></p> <p class="MsoNormal" style="mso-margin-top-alt: auto; mso-margin-bottom-alt: auto; line-height: 200%;"><span style="font-family: 'Times New Roman',serif;">Hiperandrogenizam, koji se manifestuje kao hirzutizam, akne ili androgena alopecija, </span><span lang="SR-LATN-RS" style="font-family: 'Times New Roman',serif; mso-ansi-language: SR-LATN-RS;">značajno </span><span style="font-family: 'Times New Roman',serif;">utiče kako na fizičko, tako i na psihičko stanje ovih pacijentkinja. Ovulatorna disfunkcija, koja se manifestuje iregularnim menstruacionim ciklusima kao posledica oligo/anovulacije, predstavlja zna</span><span lang="SR-LATN-RS" style="font-family: 'Times New Roman',serif; mso-ansi-language: SR-LATN-RS;">čajan element kliničke prezentacije PCOS-a i uzrokuje infertilitet koji se sreće kod pojedinih </span><span style="font-family: 'Times New Roman',serif;">pacjentkinja. Takođe, insulinska rezistencija koja je karakteristična za PCOS dovodi do hiperinsulinemije i metaboličkih poremećaja koji se sreću kod ovih pacijentkinja. Posledično, </span><span lang="SR-LATN-RS" style="font-family: 'Times New Roman',serif; mso-ansi-language: SR-LATN-RS;">ž</span><span style="font-family: 'Times New Roman',serif;">ene sa PCOS imaju povećan rizik gojaznosti, displipidemije, dijabetesa, i kardiovaskularnih bolesti, naročito u kasnijoj životnoj dobi. Učestalost poremećaja raspoloženja, pre svega depresije i anksioznosti takođe je značajno povećana u ovoj populaciji. </span></p> <p class="MsoNormal" style="mso-margin-top-alt: auto; mso-margin-bottom-alt: auto; line-height: 200%;"><span style="font-family: 'Times New Roman',serif;">Kompleksnost sindroma otežava brigu o pacijentkinjama, a njegova hronična priroda ističe potrebu za proaktivnim pristupom lečenju i pažljivom procenom svih elemenata oboljenja.</span></p>
2024-10-14T10:26:25+02:00
Sva prava zadržana (c) 2024 Medicinska istraživanja
https://aseestant.ceon.rs/index.php/medi/article/view/50984
Primarni lejomiosarkom donje šuplje vene - radikalna resekcija i vaskularna rekonstrukcija - prikaz slučaja
2024-11-20T08:29:33+01:00
Ognjen Petrovic
ognjenpetrovic54@gmail.com
Srdjan Nikolic
onkosurge1@yahoo.com
Igor Djurisic
drigordjurisic@gmail.com
Milan Kocic
kocic011@gmail.com
Andjela Babic
andjela.ug@gmail.com
Vladimir Jokic
vladimir.jokic90@gmail.com
Luka Pejnovic
lpejnovic14@gmail.com
Nikola Vucic
nikola.vucic91@gmail.com
Stefan Gacic
stefan.gacic@yahoo.com
Lila Rajacic
lilaa.rajacic@gmail.com
<p class="MsoNormal" style="text-indent: 0in;"><strong style="mso-bidi-font-weight: normal;"><span style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman','serif';">Uvod:</span></strong><span style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman','serif';"> Sarkomi su retki tumori koji čine manje od 1% malignih tumora kod odraslih. Primarni lejomiosarkom donje šuplje vene je veoma redak tumor čija je incidencija<span style="mso-spacerun: yes;"> </span><1/100 000 svih malignih bolesti kod odraslih. U ovom radu predstavljen je slučaj žene, upravo, sa lejomiosarkomom donje šuplje vene kojoj je urađena radikalna resekcija tumora uz vaskularnu rekonstrukciju.</span></p> <p class="MsoNormal" style="text-indent: 0in;"><strong style="mso-bidi-font-weight: normal;"><span style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman','serif';">Prikaz bolesnika:</span></strong><span style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman','serif';"> Žena stara 71 godinu, javila se lekaru zbog bezbolne hematurije. U sklopu dijagnostičke evaluacije pored UZ i CT pregleda abdomena učinjena je i CT angiografija sa 3D rekonstrukcijom. Zaključak radiologa je bio da opisana tumorska masa najpre odgovara primarnom lejomiosarkomu donje šuplje vene koji se lateralno levo propagirao u lumen leve bubrežne vene, dok je desna bubrežna arterija bila infiltrisana tumorom. Pacijentkinja je prikazana konzilijumu na Institutu za onkologiju i radiologiju Srbije koji je doneo odluku o operativnom lečenju. Tumor je u celosti odstranjen u bloku sa desnim bubregom, desnom nadbubrežnom žlezdom i ušćem leve bubrežne vene u donju šuplju venu. Donja šuplja vena je rekonstruisana uz pomoć grafta termino-terminalnom anastomozom, dok je leva bubrežna vena implantirana u graft termino-lateralnom anastomozom. Postoperativni tok kod pacijentkinje je uredno protekao i ona je VIII postoperativnog dana otpuštena iz bolnice.</span></p> <p class="MsoNormal" style="text-indent: 0in;"><strong style="mso-bidi-font-weight: normal;"><span style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman','serif';">Zaključak:</span></strong><span style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman','serif';"> <span style="color: black;">Lejomiosarkom donje šuplje vene je ekstremno redak tumor. Hirurška resekcija tumora I zahvaćenog krvnog suda sa negativnim ivicama resekcije je jedina terapijska opcija koja poboljšava preživljavanje. Vrlo često uz komplikovane vaskularne rekonstrukcije, hirurgija uključuje i multivisceralne resekcije, kako bi se postigao najbolji mogući terapijski efekat.</span></span></p>
2024-10-21T10:28:21+02:00
Sva prava zadržana (c) 2024 Medicinska istraživanja
https://aseestant.ceon.rs/index.php/medi/article/view/52532
Хистопатолошки алати у дијагнози Хиршпрунгове болести и сродних обољења
2024-11-20T08:29:33+01:00
Radmila Janković
radmila.jankovic@med.bg.ac.rs
Miloš Đuknić
milos.djuknic@med.bg.ac.rs
Jovan Jevtić
jovan.jevtic@med.bg.ac.rs
Milica Labudović Borović
milica.labudovic-borovic@med.bg.ac.rs
Dragana Vujović
dr.v.dragana@gmail.com
Sanja Sinđić-Antunović
sanja.sindjic.antunovic@gmail.com
Đorđe Topličić
drdjordjetoplicic@gmail.com
Milena Backović
mimab1997@gmail.com
Dunja Putniković
putnikovicc@gmail.com
Jelena Jovanović
mmjeka@hotmail.com
<p> </p> <p class="MsoNormal" style="margin-bottom: 0cm; line-height: 150%;"><span lang="SR-CYRL-RS" style="font-size: 12.0pt; line-height: 150%; font-family: 'Times New Roman',serif; mso-ansi-language: SR-CYRL-RS;">Дијагностика Хиршпрунгове болести</span> <span lang="SR-CYRL-RS" style="font-size: 12.0pt; line-height: 150%; font-family: 'Times New Roman',serif; mso-ansi-language: SR-CYRL-RS;">(ХБ) и сродних поремећаја може бити сложена и захтева добро познавање механизама који регулишу цревни мотилитет, као што су ентерички нервни систем (ЕНС), интерстицијске Кахалове ћелије (ИКЋ) и мишићни омотач црева. Лондонска класификација идентификује три групе гастроинтестиналних неуромускуларних поремећаја: неуропатије, миопатије и абнормалности ИКЋ. Хирсчспрунгова болест коју одликује одсуство ганглијских ћелија, је најчешћа цревна неуропатија и резултат је поремећене миграције ћелија нервног гребена током развоја. Погађа око 1 од 5 000 живорођене деце и укључује више гена, међу којима је најзначајнији </span><em><span style="font-size: 12.0pt; line-height: 150%; font-family: 'Times New Roman',serif;">RET</span></em><span lang="SR-CYRL-RS" style="font-size: 12.0pt; line-height: 150%; font-family: 'Times New Roman',serif; mso-ansi-language: SR-CYRL-RS;"> ген. ХБ обично погађа ректум и део колона, са различитим степенима аганглионозе. Дијагноза се заснива на хистопатолошкој анализи сукционих биопсија - одсуству ганглијских ћелија и присуству дебелих субмукозних нерава на стандардном хематоксилин и еозин бојеном препарату, допуњеном ензимохистохемијским бојењем (метода ацетилхолинестеразе) или имунохистохемијским (калретинин и друга антитела) бојењем. Лечење ХБ подразумева хируршку ресекцију аганглионарног сегмента црева. Тачна интраоперативна процена ткивних маргина је кључна за превенцију постоперативних компликација условљених псеудообструкцијом. Комуникација између хирурга и патолога је од суштинског значаја за постизање успешног терапијског исхода.</span></p> <p class="MsoNormal" style="margin-bottom: 0cm; line-height: 150%;"><span lang="SR-CYRL-RS" style="font-size: 12.0pt; line-height: 150%; font-family: 'Times New Roman',serif; mso-ansi-language: SR-CYRL-RS;">Остале цревне неуропатије укључују интестиналну хипоганглионозу, хиперганглионозу, одложено сазревање ганглијских ћелија и глиопатије. Интестиналне миопатије су изузетно ретка стања, са типичним морфолошким променама као што су атрофија мишићног омотача црева, интрацелуларна вакуолизација глатких мишићних ћелија и интерстицијална фиброза. Поремећај у мрежи и распореду ИКЋ чини морфолошку основу за констипацију спорог пролаза. Сваки од поменутих поремећаја има јединствене карактеристике и дијагностичке изазове. Дијагностиковање ових стања често захтева комбинацију хистолошких, хистохемијских, имунохистохемијских и понекад генетских анализа. Интеграција ових метода је од виталног значаја за тачну дијагнозу и ефикасно планирање лечења.</span></p> <p class="MsoNormal" style="margin-bottom: 0cm; line-height: 150%;"><span lang="SR-CYRL-RS" style="font-size: 12.0pt; line-height: 150%; font-family: 'Times New Roman',serif; mso-ansi-language: SR-CYRL-RS;">Укратко, сложеност поремећаја цревног дисмотилитета захтева детаљно разумевање цревног мотилитета и коришћење напредних дијагностичких метода како би се пружиле тачне дијагнозе и ефикасни третмани.</span></p> <p> </p>
2024-10-21T10:30:45+02:00
Sva prava zadržana (c) 2024 Medicinska istraživanja
https://aseestant.ceon.rs/index.php/medi/article/view/53019
Age, Glasgow Coma Scale and vasopressors can predict mortality in traumatized patients treated in the ICU
2024-11-20T08:29:34+01:00
Sofija Mirosavljević
mala.sof.5@gmail.com
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Name="Document Map"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Plain Text"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="E-mail Signature"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="HTML Top of Form"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="HTML Bottom of Form"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Normal (Web)"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="HTML Acronym"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="HTML Address"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="HTML Cite"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="HTML Code"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="HTML Definition"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="HTML Keyboard"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="HTML Preformatted"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="HTML Sample"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="HTML Typewriter"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="HTML Variable"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Normal Table"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="annotation subject"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="No List"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Outline List 1"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Outline List 2"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Outline 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SemiHidden="true" UnhideWhenUsed="true" Name="Table Columns 1"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Table Columns 2"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Table Columns 3"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Table Columns 4"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Table Columns 5"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Table Grid 1"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Table Grid 2"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Table Grid 3"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Table Grid 4"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Table Grid 5"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Table 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Name="Medium Grid 2"/> <w:LsdException Locked="false" Priority="69" Name="Medium Grid 3"/> <w:LsdException Locked="false" Priority="70" Name="Dark List"/> <w:LsdException Locked="false" Priority="71" Name="Colorful Shading"/> <w:LsdException Locked="false" Priority="72" Name="Colorful List"/> <w:LsdException Locked="false" Priority="73" Name="Colorful Grid"/> <w:LsdException Locked="false" Priority="60" Name="Light Shading Accent 1"/> <w:LsdException Locked="false" Priority="61" Name="Light List Accent 1"/> <w:LsdException Locked="false" Priority="62" Name="Light Grid Accent 1"/> <w:LsdException Locked="false" Priority="63" Name="Medium Shading 1 Accent 1"/> <w:LsdException Locked="false" Priority="64" Name="Medium Shading 2 Accent 1"/> <w:LsdException Locked="false" Priority="65" Name="Medium List 1 Accent 1"/> <w:LsdException Locked="false" SemiHidden="true" Name="Revision"/> <w:LsdException Locked="false" Priority="34" QFormat="true" Name="List Paragraph"/> <w:LsdException 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<w:LsdException Locked="false" Priority="62" Name="Light Grid Accent 3"/> <w:LsdException Locked="false" Priority="63" Name="Medium Shading 1 Accent 3"/> <w:LsdException Locked="false" Priority="64" Name="Medium Shading 2 Accent 3"/> <w:LsdException Locked="false" Priority="65" Name="Medium List 1 Accent 3"/> <w:LsdException Locked="false" Priority="66" Name="Medium List 2 Accent 3"/> <w:LsdException Locked="false" Priority="67" Name="Medium Grid 1 Accent 3"/> <w:LsdException Locked="false" Priority="68" Name="Medium Grid 2 Accent 3"/> <w:LsdException Locked="false" Priority="69" Name="Medium Grid 3 Accent 3"/> <w:LsdException Locked="false" Priority="70" Name="Dark List Accent 3"/> <w:LsdException Locked="false" Priority="71" Name="Colorful Shading Accent 3"/> <w:LsdException Locked="false" Priority="72" Name="Colorful List Accent 3"/> <w:LsdException Locked="false" Priority="73" Name="Colorful Grid Accent 3"/> <w:LsdException Locked="false" Priority="60" Name="Light Shading Accent 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Name="Plain Table 3"/> <w:LsdException Locked="false" Priority="44" Name="Plain Table 4"/> <w:LsdException Locked="false" Priority="45" Name="Plain Table 5"/> <w:LsdException Locked="false" Priority="40" Name="Grid Table Light"/> <w:LsdException Locked="false" Priority="46" Name="Grid Table 1 Light"/> <w:LsdException Locked="false" Priority="47" Name="Grid Table 2"/> <w:LsdException Locked="false" Priority="48" Name="Grid Table 3"/> <w:LsdException Locked="false" Priority="49" Name="Grid Table 4"/> <w:LsdException Locked="false" Priority="50" Name="Grid Table 5 Dark"/> <w:LsdException Locked="false" Priority="51" Name="Grid Table 6 Colorful"/> <w:LsdException Locked="false" Priority="52" Name="Grid Table 7 Colorful"/> <w:LsdException Locked="false" Priority="46" Name="Grid Table 1 Light Accent 1"/> <w:LsdException Locked="false" Priority="47" Name="Grid Table 2 Accent 1"/> <w:LsdException Locked="false" Priority="48" Name="Grid Table 3 Accent 1"/> <w:LsdException Locked="false" Priority="49" Name="Grid Table 4 Accent 1"/> <w:LsdException Locked="false" Priority="50" Name="Grid Table 5 Dark Accent 1"/> <w:LsdException Locked="false" Priority="51" Name="Grid Table 6 Colorful Accent 1"/> <w:LsdException Locked="false" Priority="52" Name="Grid Table 7 Colorful Accent 1"/> <w:LsdException Locked="false" Priority="46" Name="Grid Table 1 Light Accent 2"/> <w:LsdException Locked="false" Priority="47" Name="Grid Table 2 Accent 2"/> <w:LsdException Locked="false" Priority="48" Name="Grid Table 3 Accent 2"/> <w:LsdException Locked="false" Priority="49" Name="Grid Table 4 Accent 2"/> <w:LsdException Locked="false" Priority="50" Name="Grid Table 5 Dark Accent 2"/> <w:LsdException Locked="false" Priority="51" Name="Grid Table 6 Colorful Accent 2"/> <w:LsdException Locked="false" Priority="52" Name="Grid Table 7 Colorful Accent 2"/> <w:LsdException Locked="false" Priority="46" Name="Grid Table 1 Light Accent 3"/> <w:LsdException Locked="false" Priority="47" Name="Grid Table 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</xml><![endif]--><!-- [if gte mso 10]> <style> /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin-top:0in; mso-para-margin-right:0in; mso-para-margin-bottom:8.0pt; mso-para-margin-left:0in; line-height:107%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri",sans-serif; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi; mso-font-kerning:1.0pt; mso-ligatures:standardcontextual;} </style> <![endif]--></p> <p class="MsoNormal" style="margin-bottom: .0001pt; line-height: 200%;"><strong><span style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;">Uvod </span></strong><span style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;">– Trauma predstavlja jedan od najznačajnijih javnozdravstvenih problema širom sveta. Ona je jedan od vodećih uzroka smrtnosti, posebno u populaciji mladih, ali sa značajno većim udelom nefatalnih povreda koje rezultiraju doživotnim invaliditetom i zdravstvenim posledicama. Pravilna i blagovremena identifikacija pacijenata sa većim rizikom od mortaliteta je ključna za bolje ishode. </span><span style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif; mso-fareast-font-family: Calibri;">Cilj ove studije je da ispita potencijalne prediktor smrtnog ishoda kod pacijenata koji su preživeli traumu, a leče se u jedinici intenzivnog lečenja.</span></p> <p class="MsoNormal" style="margin-bottom: .0001pt; line-height: 200%;"><strong><span style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;">Metode</span></strong><span style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;"> - Retrospektivna kohortna studija je sprovedena u traumatološkoj, 12-krevetnoj intenzivnoj intenzivnoj pomoći Univerzitetskog urgentnog centra Kliničkog centra Srbije, Beograd. Svi uzastopni pacijenti sa tupim traumama primljeni su u intenzivnu intenzivnu terapiju između avgusta 2021. i avgusta 2022. Primarni ishodi od interesa bili su bolnička smrtnost od svih uzroka. Vrednost p < 0,05 smatrana je statistički značajnom.</span></p> <p class="MsoNormal" style="margin-bottom: .0001pt; line-height: 200%;"><strong><span style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;">Rezultati</span></strong><span style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;">- <em>GCS</em> (koeficijent opasnosti 0,924 95%CI 0,873 – 0,979), vazopresori (koeficijent opasnosti 3,47 95%CI 1,373 – 8,787) i starost (odnos opasnosti 1,030 95%CI 1,030 95%CI 1,0147 individualno) predikt.</span></p> <p class="MsoNormal" style="margin-bottom: .0001pt; line-height: 200%;"><strong><span style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;">Zaključak</span></strong><span style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;"> – Ova studija ukazuje na faktore rizika za nepovoljne kliničke ishode nakon teške traume.To može biti od izuzetnog značaja da bi se na vreme izdvojili pojedinci sa lošom prognozom, kako bi se što pre započela adekvatna intenzivna terapija i time smanjila smrtnost. Starost, vazopresori i mehanička ventilacija, nezavisno mogu biti prediktori letalnog ishoda kod pacijenata koji su preživeli traumu, a leče se u jedinici intenzivnog lečenja.</span></p>
2024-10-21T10:32:40+02:00
Sva prava zadržana (c) 2024 Medicinska istraživanja
https://aseestant.ceon.rs/index.php/medi/article/view/53024
MEDIKAMENTOZNA TERAPIJA POSTOPERATIVNOG BOLA
2024-11-20T08:29:34+01:00
Katarina R Savić Vujović
katarinasavicvujovic@gmail.com
Sonja Vučković
vuckovicsonja1@gmail.com
Branislava Medić
brankicamedic@gmail.com
Dragana Srebro
srebrodragana1@gmail.com
Ana Jotić
anajotic@yahoo.com
<p class="MsoNormal" style="mso-margin-top-alt: auto; mso-margin-bottom-alt: auto; line-height: 150%;"><span style="font-size: 12.0pt; line-height: 150%; font-family: 'Times New Roman','serif'; mso-fareast-font-family: 'Times New Roman'; mso-bidi-font-weight: bold;">Postoperativni bol je i dalje veoma rasprostranjen i još uvek potcenjen problem kako u našoj zemlji, tako i u svetu. Brojne studije koje su sprovedene u zemljama s razvijenim sistemom zdravstvene zaštite pokazale su da čak ni u 21. veku postoperativni bol nije adekvatno tretiran. Više od 80% pacijenata koji se podvrgavaju hirurškim procedurama iskuse akutni postoperativni bol, a 75% pacijenata opisuju akutni bol kao srednje težak, težak ili ekstreman. Postoperativni oporavak zavisi od karakteristika pacijenta, ali i od faktora koji omogućavaju postoperativni oporavak, odnosno od prisustva ili odsustva komplikacija posle operacije. Farmakologija postoperativnog bola je usmerena prema patofiziološkim mehanizmima kao što su: nocicepcija, periferna senzitizacija, ektopična aktivnost, centralna senzitizacija. Savremeno medikamentno lečenje postoperativnog bola podrazumeva balansiranu multimodalnu analgeziju. Princip multimodalne analgezije je baziran na multifaktorijalnoj prirodi i kompleksnosti puteva prenošenja bola, a definiše se kao upotreba različitih lekova ili tehnika sa različitim mehanizmom dejstva na perifernom ili centralnom nervnom sistemu, koje mogu imati aditivan ili sinergistički efekat. Nekoliko grupa lekova je uključeno u multimodalni princip, i svaki od njih ima specifičan patofiziološki mehanizam dejstva. Efikasnost opioidnih analgetika u terapiji umerenog do teškog postoperativnog bola se ostvaruje zbog nedostatka plato efekta. Međutim, povećanjem doze dolazi do povećanja neželjenih efekata. Nesteroidni anti-inflamatorni lekovi (NSAIL), ciklooksigenaza-2 inhibitori (COX-2) i sistemski steroidi smanjuju inflamatornu komponentu hirurškog bola. Sistemski i lokalni anestetici redukuju oslobađanje inflamatornih medijatora (IL-6, Il-1β, i IL-1RA). Gabapentinoidi, vezujući se za alfa-2-delta-1 subjedinicu voltažnih kalcijumskih kanala u centralnom nervnom sistemu, redukuju oslobađanje važnih ekscitatornih neurotransmitera uključenih u nocicepciju. Alfa-2-agonisti, kao što su klonidin i deksmedetomidin, aktiviranjem presinaptičkih i postsinaptičkih α2 receptora u kičmenoj moždini modulišu transmisiju bolnih impulsa. Lokalni anestetici (lidokain) blokiraju neuralnu transmisiju blokirajući natrijumske kanale, pa preveniraju transmisiju bolnih stimulusa sa periferije u centralni nervni sistem. NMDA antagonisti, ketamin i magnezijum, smanjuju mehanizam cetralne senzitizacije.</span></p>
2024-10-21T11:28:36+02:00
Sva prava zadržana (c) 2024 Medicinska istraživanja
https://aseestant.ceon.rs/index.php/medi/article/view/52586
UTICAJ PERIFERNIH NERVNIH BLOKOVA NA INFLAMATORNI ODGOVOR POSLE ARTROPLASTIKE KOLENA
2024-11-20T08:29:35+01:00
prof. dr Svetlana Sreckovic
svetlanasreckovic@yahoo.com
Radmila Klacar
radmilaklacar@gmail.com
Ana Odalovic
anaodalovic@gmail.com
Dragana Vracevic
draganatejovic@gmail.com
Jovan Vesic
jovandvesic@gmail.com
Nikola Ladjevic
nikola.ladjevic@yahoo.com
Marko Kadija
kadija.marko@gmail.com
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mso-para-margin-right:0cm; mso-para-margin-bottom:8.0pt; mso-para-margin-left:0cm; line-height:107%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin;} </style> <![endif]--></p> <p class="MsoNormal" style="line-height: 200%;"><span style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman','serif'; color: #1d2228; background: white;">Pojačan inflamatorni odgovor nakon artroplastike kolena (TKA) rezultat je traume kosti i mekih tkiva, a njegova ekstenzivna reakcija doprinosi postoperativnom morbiditetu i mortalitetu. <strong>Metode: </strong>200 pacijenata uključeno je u ovu prospektivnu kohortnu studiju nakon elektivne TKA. U prvoj grupi pacijenata primenjeni su aduktor kanal blok i IPACK blok, a u drugoj ne. <strong>Rezultati: </strong>Bol u mirovanju imalo je manje pacijenata u grupi sa blokom i bio je manjeg intenziteta (1,18±0,76 vs. 3,35±1,18 p˂0,001). U grupi bez blokova bol je bio intenzivniji tokom kašlja (1,7±0,52 vs. 3,72±1,61 p˂0,001) i pri aktivnim pokretima operisane noge (1,67±0,83 vs. 3,78±1,94 p˂0,001). U prva 24 sata nakon operacije, u grupi sa blokovima, 22% pacijenata je koristilo opioide u dozi od 9,64±3,21 mg, dok u grupi bez bloka svi pacijenti su koristili u dozi od 30,94±11,47. Statistički značajna razlika između grupa je postojala u WBC, CRP, ESR i albuminima 1,3. i 5. dana postoperativno. Tri meseca nakon TKA, KOOS skor je bio statistički viši u grupi sa blokovima (92,6±11,73 vs 85,65±17,49 p˂0,001). <strong>Zaključak: </strong>Kombinacijom nervnih blokova obezbeđuje se adekvatna postoperativna analgeziju koja omogućava ranu rehabilitaciju, smanjuje potrošnju morfijuma, smanjuje broj WBC, CRP, ESR i albumina (1., 3. i 5. dan posle operacije) i pozitivno utiče na funkcionalni status tri meseca nakon operacije. Identifikacija i uticaj na faktore koji smanjuju lokalni i sistemski inflamatorni odgovor je od vitalnog značaja za poboljšanje oporavka nakon TKA.</span></p>
2024-10-29T08:39:04+01:00
Sva prava zadržana (c) 2024 Medicinska istraživanja
https://aseestant.ceon.rs/index.php/medi/article/view/52852
OVARIAN STIMULATION WITH FOLLITROPIN-δ REDUCES RISK OF OVARIAN HYPERSTIMULATION SYNDROME
2024-11-20T08:29:35+01:00
Milan Perovic
perovic.milan@gakfront.org
Nebojsa Zecevic
nebojsa.zecevic1@gmail.com
Dragana Bojovic Jovic
drbojovicjovic@gmail.com
Tatjana Nozic Zecevic
nozictanja@gmail.com
Aleksandar Stojsavljević
aleksandars@chem.bg.ac.rs
Gorana Nikolic
gorana.nikolic03@gmail.com
Ana Nikolic
dr.ana.nikolic11@gmail.com
<p class="MsoNormal" style="line-height: 200%;"><strong><span style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;">UVOD</span></strong></p> <p class="MsoNormal" style="line-height: 200%;"><span lang="SR-LATN-RS" style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif; mso-ansi-language: SR-LATN-RS;">Stimulacija jajnika (OS) u sklopu vantelesne oplodnje (VTO) nosi rizik sindroma ovarijalne hiperstimulacije (OHSS). Rizik je naročito izražen kod žena sa sindromom policističnih jajnika (PCOS). Rekombinantnim DNK tehnologijama stvorene su nove generacije gonadotropina, kao što je Follitropin-</span><span style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;">δ</span><span lang="SR-LATN-RS" style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif; mso-ansi-language: SR-LATN-RS;">, koje individualizovanim doziranjem na osnovu vrednosti antimilerijan hormona (AMH) i telesne mase (tm) pacijenta smanjuju rizik OHSS-a. </span></p> <p class="MsoNormal" style="line-height: 200%;"><strong><span lang="SR-LATN-RS" style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif; mso-ansi-language: SR-LATN-RS;">CILJ</span></strong></p> <p class="MsoNormal" style="line-height: 200%;"><span lang="SR-LATN-RS" style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif; mso-ansi-language: SR-LATN-RS;">Uporediti prevalencu OHSS-a i efikasnost OS individualizovanim doziranjem Follitropinom-</span><span style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;">δ</span><span style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif; mso-ansi-language: SR-LATN-RS;"> <span lang="SR-LATN-RS">i standardnim doziranjem starijim generacijama gonadotropina u populaciji žena sa PCOS-om.</span></span></p> <p class="MsoNormal" style="line-height: 200%;"><strong><span lang="SR-LATN-RS" style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif; mso-ansi-language: SR-LATN-RS;">METODE</span></strong></p> <p class="MsoNormal" style="line-height: 200%;"><span lang="SR-LATN-RS" style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif; mso-ansi-language: SR-LATN-RS;">U studiji kontrole slučajeva radnu grupu činile su 24 žene stimulisane individualizovanim doziranjem Follitropinom-</span><span style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;">δ</span><span lang="SR-LATN-RS" style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif; mso-ansi-language: SR-LATN-RS;">, a kontrolnu 48 žena standardnim doziranjem starijim generacijama gonadotropina. Studijski kriterijumi za uključivanje: PCOS, odnosno isključivanje: ostali uzroci infertiliteta. Ispitanice radne grupe uparene su sa ispitanicama kontrolne grupe na osnovu AMH, tm, godina starosti i pušačkog statusa.</span></p> <p class="MsoNormal" style="line-height: 200%;"><strong><span lang="SR-LATN-RS" style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif; mso-ansi-language: SR-LATN-RS;">REZULTATI</span></strong></p> <p class="MsoNormal" style="line-height: 200%;"><span lang="SR-LATN-RS" style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif; mso-ansi-language: SR-LATN-RS;">U radnoj grupi prevalenca umerenih (0% vs. 5.9%) i težih (0% vs. 17.6%) formi OHSS-a značano je manja (p=0.009) u odnosu na kontrolnu grupu. Trajanje OS (9.06±1.53 dana vs. 10.00±1.13 dana, p=0.01) i primenjena doza gonadotropina (1,117.95±234.90 vs. 1,940.33±501.20 IU, p<0.001) značajno su manji u radnoj grupi. Broj dobijenih embriona visokog kvaliteta veći je u radnoj grupi (3.33±1.13 vs. 2.20±0.96, p<0.001).</span></p> <p class="MsoNormal" style="line-height: 200%;"><strong><span lang="ES" style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif; mso-ansi-language: ES;">ZAKLJUČAK</span></strong></p> <p class="MsoNormal" style="line-height: 200%;"><span lang="ES" style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif; mso-ansi-language: ES;">Prevalenca umerenih i težih formi OHSS-a manja je kod OS </span><span lang="SR-LATN-RS" style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif; mso-ansi-language: SR-LATN-RS;">individualizovanim doziranjem Follitropinom-</span><span style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;">δ</span><span lang="ES" style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif; mso-ansi-language: ES;"> u odnosu na OS</span><span lang="SR-LATN-RS" style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif; mso-ansi-language: SR-LATN-RS;"> standardnim doziranjem starijim generacijama gonadotropina. Efikasnost OS u studijskim grupama nije se značajno razlikovala, osim kraćeg trajanja OS, manje primenjene ukupne doze gonadotropina i znatno većeg broja dobijenih visoko kvalitetnih embriona, a koji su zabeleženi kod OS individualizovanim doziranjem Follitropinom-</span><span style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;">δ</span><span lang="SR-LATN-RS" style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif; mso-ansi-language: SR-LATN-RS;">.</span></p>
2024-10-29T09:05:02+01:00
Sva prava zadržana (c) 2024 Medicinska istraživanja
https://aseestant.ceon.rs/index.php/medi/article/view/53338
UNAPREĐIVANJE FUNKCIONALNOG OPORAVKA BALNEOTERAPIJOM NAKON ARTROPLASTIKE KUKA
2024-11-20T08:29:35+01:00
Attila Klimó
petik@stcable.net
Rada Jeremić
rada.jeremic@med.bg.ac.rs
Predrag Brkić
predrag.brkic@med.bg.ac.rs
Mina Bogetić
mina.bogetic@med.bg.ac.rs
Marija Babić
marijabb222@gmail.com
<p class="MsoNoSpacing" style="line-height: 200%;"><span class="MsoHyperlink"><strong style="mso-bidi-font-weight: normal;"><span lang="EN-US" style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;">Uvod:</span></strong></span><span class="MsoHyperlink"><span lang="EN-US" style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;"> Balneoterapija je terapijski pristup koji koristi prirodne elemente kao sredstvo lečenja. Artroplastika kuka je hirurška procedura koja pomaže u rešavanju disfunkcije zgloba kuka i pokazala se efikasnom. Ova studija ima za cilj da istraži da li upotreba termomineralne vode može poboljšati oporavak funkcionalnih sposobnosti i poboljšati kvalitet života pacijenata koji su bili podvrgnuti artroplastici kuka.</span></span></p> <p class="MsoNoSpacing" style="line-height: 200%;"><span class="MsoHyperlink"><strong style="mso-bidi-font-weight: normal;"><span lang="EN-US" style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;">Materijal i metode:</span></strong></span><span class="MsoHyperlink"><span lang="EN-US" style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;"> U studiju su uključeni pacijenti (n=100) koji su bili podvrgnuti artroplastici kuka i učestvovali u vežbama hidrokineze u bazenima sa termomineralnom vodom, pored konvencionalnog programa terapijske rehabilitacije na suvom. Evaluacija je uključivala procene opsega pokreta zgloba kuka i snage ključnih mišića pokretača zgloba kuka. Ispitanici su takođe ocenili uspeh protokola na osnovu parametra poboljšanja kvaliteta života.</span></span></p> <p class="MsoNoSpacing" style="line-height: 200%;"><span class="MsoHyperlink"><strong style="mso-bidi-font-weight: normal;"><span lang="EN-US" style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;">Rezultati:</span></strong></span><span class="MsoHyperlink"><span lang="EN-US" style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;"> Rezultati istraživanja su pokazali da je primena balneoloških sredstava sa specifičnog izvora termomineralne vode „Banja Kanjiža” značajno ubrzala oporavak funkcionalnih sposobnosti i poboljšala kvalitet života pacijenata koji su bili podvrgnuti operaciji artroplastike kuka.</span></span></p> <p class="MsoNoSpacing" style="line-height: 200%;"><span class="MsoHyperlink"><strong style="mso-bidi-font-weight: normal;"><span lang="EN-US" style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;">Zaključak:</span></strong></span><span class="MsoHyperlink"><span lang="EN-US" style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;"> Da bi se dalje proverila efikasnost balneoterapije, neophodna su koordinirana multicentrična klinička ispitivanja i fundamentalna istraživanja. Takođe su važni uporni napori da se prošire prednosti prirodnih lekovitih sredstava, stručnost kvalifikovanih zdravstvenih stručnjaka i infrastruktura razvijenih spa centara za stanovnike i svetsko stanovništvo.</span></span></p> <p class="MsoNoSpacing" style="line-height: 200%;"><span class="MsoHyperlink"><strong style="mso-bidi-font-weight: normal;"><span lang="EN-US" style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;">Ključne reči</span></strong></span><span class="MsoHyperlink"><span lang="EN-US" style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;">: balneoterapija, artroplastika kuka, rehabilitacija</span></span></p>
2024-10-29T09:35:58+01:00
Sva prava zadržana (c) 2024 Medicinska istraživanja
https://aseestant.ceon.rs/index.php/medi/article/view/54347
100 GODINA INSTITUTA ZA HEMIJU U MEDICINI MEDICINSKOG FAKULTETA UNIVERZITETA U BEOGRADU
2024-11-20T08:29:36+01:00
Kristina Gopčević
kristinagopcevic@yahoo.com
Vesna Vujić
vesna.vujic@med.bg.ac.rs
Nataša Avramović
natasa.avramovic@med.bg.ac.rs
Lidija Izrael Živković
lidija.izrael-zivkovic@med.bg.ac.rs
Ana Medić
ana.medic@med.bg.ac.rs
Teodora Đukić
teodora.djukic@med.bg.ac.rs
Zorana Lopandić
zorana.lopandic@med.bg.ac.rs
Danijela Krstić
danijela.krstic@med.bg.ac.rs
<p class="MsoNormal" style="margin-bottom: 0cm; line-height: 200%;"><span lang="EN-US" style="font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;">Institut za hemiju u medicini <a name="_Hlk180604462"></a>“Prof. dr Petar Matavulj”, jedan od najstarijih instituta Medicinskog fakulteta Univerziteta u Beogradu, osnovan je 1923. godine. Sagledavajući ulogu hemije u razumevanju medicinskih nauka, osnivači Medicinskog fakulteta angažovali su vodeće autoritete toga doba u oblasti hemije: Simu Lozanića, Milivoja Lozanića i Petra Matavulja, postavivši čvrste temelje za kvalitetnu edukaciju budućih lekara. Tokom više od jednog veka, nastavnici i saradnici instituta uspešno odgovaraju na specifične izazove u medicinskoj edukaciji, prilagođavajući se savremenim trendovima u nauci i obrazovanju.</span></p> <p class="MsoNormal" style="margin-bottom: 0cm; line-height: 200%;"> </p>
2024-10-29T09:38:48+01:00
Sva prava zadržana (c) 2024 Medicinska istraživanja
https://aseestant.ceon.rs/index.php/medi/article/view/54466
Appendix Vol. 57 Br. 4- Simpozijum ,,Stremljenja i novine u medicini“
2024-11-20T08:29:36+01:00
Dragana Popović
dragana.popovic@med.bg.ac.rs
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mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} </style> <![endif]--></p> <p class="MsoNormal">Apstrakti radova sa tradicionalnog simpozijuma ,,Stremljenja i novine u medicini” Medicinskog fakulteta u Beogradu koji se održava povodom Dana fakulteta 9. decembra.</p> <p class="MsoNormal"> </p>
2024-10-30T12:22:49+01:00
Sva prava zadržana (c) 2024 Medicinska istraživanja
https://aseestant.ceon.rs/index.php/medi/article/view/53290
OKSIDATIVNI STRESS I OPSTETRIČKE KOMPLIKACIJE KOD TRUDNICA SA NASLEDNOM TROMBOFILIJOM, SA I BEZ TERAPIJE HEPARINOM NISKE MOLEKULSKE TEŽINE
2024-11-20T08:29:36+01:00
Dragana Maglic
dragana.maglic@gmail.com
Vesna Mandic Markovic
vesna.m.mandic@gmail.com
Jelena Bogdanovic Pristov
jelenabog@gmail.com
Rastko Maglic
rastko.maglic@gmail.com
Olivera Dzatic Smiljkovic
lola.dzatic.smiljkovic@gmail.com
Radomir Anicic
radomir.anicic@gmail.com
Milica Mandic
milica96mandic@gmail.com
Jelena Mitrovic
jelenavugdelic@gmail.com
Sabrina Skrijelj
skrijelj.sabrina@outlook.com
<p class="MsoNormal" style="line-height: 200%;"><strong><span lang="EN-US">Uvod:</span></strong><span lang="EN-US"> Urođena trombofilija (UT) predstavlja stanje udruženo sa rizikom od duboke vaskularne tromboze (DVT) i obstetričkih komplikacija (OK) kao što su preeklampsija (PE), zastoj u rastu ploda (IUZR), mrtvorođenost i abrupcija placente (PA). </span></p> <p class="MsoNormal" style="line-height: 200%;"><strong><span lang="EN-US">Cilj studije</span></strong><span lang="EN-US">: da se proceni učestalost OC i oksidativnog stresa (OS) kod žena sa IT tokom trudnoće sa i bez terapije niske molekulske težine (LMVH), u poređenju sa ženama sa zdravim trudnoćama.</span></p> <p class="MsoNormal" style="line-height: 200%;"><strong><span lang="EN-US">Metodologija</span></strong><span lang="EN-US">: U studiju je uključeno 60 trudnica sa UT dijagnostikovanom pre aktuelne trudnoće na osnovu prethodne DVT ili OK (ispitivana grupa) i 60 zdravih trudnica (kontrolna grupa). Kod svih ispitanica uzet je uzorak krvi pre porođaja, kao i uzorak placentnog tkiva I određena je aktivnost CAT, GPX, GH, SH, </span><span lang="EN-US">GR, CuZnSOD i MnSOD. </span></p> <p class="MsoNormal" style="line-height: 200%;"><strong><span lang="EN-US">Rezultati:</span></strong><span lang="EN-US"> Nakon uvođenja NMH u terapiju žena sa UT značajno je smanjen broj OK. Analizom povezanosti OK i različitih tipova UT, nađena je značajna povezanost samo </span><span lang="EN-US">između mutacije faktora <span style="background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;">V Leiden i deficit proteina C sa gestacijskom hipertenzijom/preeklampsijom. Nivo S</span>H je povišen kod UT; CAT, GPH i GR pokazuju tri puta povišenu aktivnost kod žena sa UT na terapiji NMH u poređenju sa kontrolnim grupom.</span></p> <p> </p> <p class="MsoNormal" style="line-height: 200%;"><strong><span lang="EN-US">Zaključak </span></strong><span lang="EN-US">Vrednosti parametara OS kod trudnica sa UT tokom porođaja mogu da potvrde prisustvo OS i ukažu na opravdanost primene antioksidativne terapije. </span></p>
2024-10-31T08:42:58+01:00
Sva prava zadržana (c) 2024 Medicinska istraživanja
https://aseestant.ceon.rs/index.php/medi/article/view/52347
ERECTOR SPINAE PLANE BLOK KAO TRETMAN AKUTNOG BOLA NAKON MASTEKTOMIJE - ISKUSTVO JEDNOG CENTRA INSTITUTA ZA ONKOLOGIJU I RADIOLOGIJU SRBIJE
2024-11-20T08:29:36+01:00
Ana Cvetković
anadjurdjic@yahoo.com
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SemiHidden="true" UnhideWhenUsed="true" Name="Table Colorful 3"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Table Columns 1"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Table Columns 2"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Table Columns 3"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Table Columns 4"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Table Columns 5"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Table Grid 1"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Table Grid 2"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Table Grid 3"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Table Grid 4"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Table 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UnhideWhenUsed="true" Name="Table List 8"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Table 3D effects 1"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Table 3D effects 2"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Table 3D effects 3"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Table Contemporary"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Table Elegant"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Table Professional"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Table Subtle 1"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Table Subtle 2"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Table Web 1"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Table 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Locked="false" Priority="67" Name="Medium Grid 1"/> <w:LsdException Locked="false" Priority="68" Name="Medium Grid 2"/> <w:LsdException Locked="false" Priority="69" Name="Medium Grid 3"/> <w:LsdException Locked="false" Priority="70" Name="Dark List"/> <w:LsdException Locked="false" Priority="71" Name="Colorful Shading"/> <w:LsdException Locked="false" Priority="72" Name="Colorful List"/> <w:LsdException Locked="false" Priority="73" Name="Colorful Grid"/> <w:LsdException Locked="false" Priority="60" Name="Light Shading Accent 1"/> <w:LsdException Locked="false" Priority="61" Name="Light List Accent 1"/> <w:LsdException Locked="false" Priority="62" Name="Light Grid Accent 1"/> <w:LsdException Locked="false" Priority="63" Name="Medium Shading 1 Accent 1"/> <w:LsdException Locked="false" Priority="64" Name="Medium Shading 2 Accent 1"/> <w:LsdException Locked="false" Priority="65" Name="Medium List 1 Accent 1"/> <w:LsdException Locked="false" SemiHidden="true" Name="Revision"/> <w:LsdException Locked="false" QFormat="true" Name="List Paragraph"/> <w:LsdException Locked="false" Priority="29" QFormat="true" Name="Quote"/> <w:LsdException Locked="false" Priority="30" QFormat="true" Name="Intense Quote"/> <w:LsdException Locked="false" Priority="66" Name="Medium List 2 Accent 1"/> <w:LsdException Locked="false" Priority="67" Name="Medium Grid 1 Accent 1"/> <w:LsdException Locked="false" Priority="68" Name="Medium Grid 2 Accent 1"/> <w:LsdException Locked="false" Priority="69" Name="Medium Grid 3 Accent 1"/> <w:LsdException Locked="false" Priority="70" Name="Dark List Accent 1"/> <w:LsdException Locked="false" Priority="71" Name="Colorful Shading Accent 1"/> <w:LsdException Locked="false" Priority="72" Name="Colorful List Accent 1"/> <w:LsdException Locked="false" Priority="73" Name="Colorful Grid Accent 1"/> <w:LsdException Locked="false" Priority="60" Name="Light Shading Accent 2"/> <w:LsdException Locked="false" Priority="61" Name="Light List Accent 2"/> 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Locked="false" Priority="52" Name="Grid Table 7 Colorful Accent 4"/> <w:LsdException Locked="false" Priority="46" Name="Grid Table 1 Light Accent 5"/> <w:LsdException Locked="false" Priority="47" Name="Grid Table 2 Accent 5"/> <w:LsdException Locked="false" Priority="48" Name="Grid Table 3 Accent 5"/> <w:LsdException Locked="false" Priority="49" Name="Grid Table 4 Accent 5"/> <w:LsdException Locked="false" Priority="50" Name="Grid Table 5 Dark Accent 5"/> <w:LsdException Locked="false" Priority="51" Name="Grid Table 6 Colorful Accent 5"/> <w:LsdException Locked="false" Priority="52" Name="Grid Table 7 Colorful Accent 5"/> <w:LsdException Locked="false" Priority="46" Name="Grid Table 1 Light Accent 6"/> <w:LsdException Locked="false" Priority="47" Name="Grid Table 2 Accent 6"/> <w:LsdException Locked="false" Priority="48" Name="Grid Table 3 Accent 6"/> <w:LsdException Locked="false" Priority="49" Name="Grid Table 4 Accent 6"/> <w:LsdException Locked="false" Priority="50" Name="Grid 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<w:LsdException Locked="false" Priority="52" Name="List Table 7 Colorful Accent 6"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Mention"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Smart Hyperlink"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Hashtag"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Unresolved Mention"/> <w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true" Name="Smart Link"/> </w:LatentStyles> </xml><![endif]--><!-- [if gte mso 10]> <style> /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin-top:0cm; mso-para-margin-right:0cm; mso-para-margin-bottom:8.0pt; mso-para-margin-left:0cm; line-height:107%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri",sans-serif; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi; mso-font-kerning:1.0pt; mso-ligatures:standardcontextual; mso-fareast-language:EN-US;} </style> <![endif]--></p> <p class="MsoNormal" style="line-height: 250%;"><strong style="mso-bidi-font-weight: normal;"><span style="font-size: 12.0pt; mso-bidi-font-size: 11.0pt; line-height: 250%; font-family: 'Times New Roman',serif; mso-fareast-font-family: Calibri;">Uvod</span></strong><span style="font-size: 12.0pt; mso-bidi-font-size: 11.0pt; line-height: 250%; font-family: 'Times New Roman',serif; mso-fareast-font-family: Calibri;">: Najčešća onkološka operacija u ženskoj populaciji je operacija raka dojke, u skladu sa visokom inidencom istog.<span style="mso-spacerun: yes;"> </span>Različiti intenziteti postoperativnog bola obično prate mastektomiju sa disekcijom aksile. <em style="mso-bidi-font-style: normal;">Erector spinae plane</em> (ESP) kao alternativni blok, je interfascijalni blok, novodefinisana tehnika regionalne anestezije za analgeziju zida grudnog koša. </span></p> <p class="MsoNormal" style="line-height: 250%;"><span style="font-size: 12.0pt; mso-bidi-font-size: 11.0pt; line-height: 250%; font-family: 'Times New Roman',serif; mso-fareast-font-family: Calibri;">U ovoj retrospektivnoj studiji, koja uključuje žene predložene za mastektomiju sa disekijom aksile na Institutu za onkologiju i radiologiju Srbije, ispitujemo efekte ESP bloka na neposredan postoperativni bol.</span></p> <p class="MsoNormal" style="line-height: 250%;"><strong style="mso-bidi-font-weight: normal;"><span style="font-size: 12.0pt; mso-bidi-font-size: 11.0pt; line-height: 250%; font-family: 'Times New Roman',serif; mso-fareast-font-family: Calibri;">Metodologija</span></strong><span style="font-size: 12.0pt; mso-bidi-font-size: 11.0pt; line-height: 250%; font-family: 'Times New Roman',serif; mso-fareast-font-family: Calibri;">:<span style="mso-spacerun: yes;"> </span>Ovom studijom obuhvaćeno je 25 pacijentkinja sa karcinomom dojke indikovanih za unilateralnu mastektomiju sa disekcijom aksile, koje su primile ESP blok uz opštu anesteziju u našem centru u periodu od 18.01.2023. do 01.05.2023.</span></p> <p class="MsoNormal" style="line-height: 250%;"><strong style="mso-bidi-font-weight: normal;"><span style="font-size: 12.0pt; mso-bidi-font-size: 11.0pt; line-height: 250%; font-family: 'Times New Roman',serif; mso-fareast-font-family: Calibri;">Rezultati:</span></strong><span style="font-size: 12.0pt; mso-bidi-font-size: 11.0pt; line-height: 250%; font-family: 'Times New Roman',serif; mso-fareast-font-family: Calibri;"> Prosečna starost pacijentkinja bila je 56,8 godina. Kod svih pacijentkinja ASA skor bio je 2. Prosečna srčana frekvencija bila je 72,08 otkucaja / minuti i došlo je do pada vrednosti na 65,32 otkucaja / minuti u intraoperativnom periodu. Incidencija bola bila je najviša u dvanaestom satu, bol je bio prisutan kod 64% pacijentkinja sa srednjim skorom Numeričke skale bola (NSB) od 2,36. Potreba za <span style="mso-bidi-font-style: italic;">dodatnom</span> analgezijom bila je značajno veća do dvanaestog sata, dok smo u dvadesetčetvrtom satu registrovali da je značajno manji broj pacijentkinja primio dodatnu analgeziju.</span></p> <p class="MsoNormal" style="line-height: 250%;"><strong style="mso-bidi-font-weight: normal;"><span style="font-size: 12.0pt; mso-bidi-font-size: 11.0pt; line-height: 250%; font-family: 'Times New Roman',serif; mso-fareast-font-family: Calibri;">Zaključak:</span></strong><span style="font-size: 12.0pt; mso-bidi-font-size: 11.0pt; line-height: 250%; font-family: 'Times New Roman',serif; mso-fareast-font-family: Calibri;"> Naši rezultati su pokazali da su pacijentkinje iz ispitivane grupe,<span style="mso-spacerun: yes;"> </span>koje su primile ESP blok uz standardni protokol, <span style="mso-spacerun: yes;"> </span>imale dobru kontrolu postoperativnog bola, na šta ukazuju niži NSB skorovi i niže stope incidencije postoperativne mučnine i povraćanja.</span></p> <p class="MsoNormal" style="line-height: 250%;"> </p>
2024-11-05T08:33:25+01:00
Sva prava zadržana (c) 2024 Medicinska istraživanja