FLAVONOIDI I NJIHOVA ANTIOKSIDATIVNA, ANTIMIKROBNA I ANTITUMORNA SVOJSTVA I KAPACITET

FLAVONOIDI - NJIHOVA SVOJSTVA I KAPACITET

  • Violeta Ilic Todorovic Akademija vaspitačko medicinskih strukovnih studija, Odsek medicinskih studija Ćuprija
  • Sladjana Piric
Ključne reči: flavonoidi, fenolna jedinjenja, antioksidativna svojstva, antimikrobna svojstva, antitumorna svojstva

Sažetak


Cilj rad je da se kroz pregled dostupnih publikovanih radova analiziraju rezultati istaživanja i prikažu opšte karakteristike flavonoida, uključujući njihov biosintetski put i osobenosti sekundardnog metabolizma. Takođe, rad prati i antioksidativna, antimikrobna i antitumorna svojstva i kapacitet flavonoida.

Flavonoidi uključujuću flavone, izoflavone i antocijanidine i formiraju se putem kondenzacije fenilpropanoida učešćem tri molekula malonil koenzima A. Sinteza flavonoida počinje od fenilalanina, pomoću enzima fenilalalnin amonijum liaze (PAL) koja katalizuje oslobadjanje fenilalanina, uz nastanak cimetne kiseline i izdvajanja amonijaka. Različitim eksperimentalnim studijama je dokazano da  je fenilalanin prekursor velikog produkata sekundardnog metabolizma fenolnih jedinjenja. Stručna literatura ističe da o-dihidroksilacija B-prstena doprinosi antioksidativnoj aktivnosti flavonoida, dok antimikrobna svojstva određuje prisustvo
(+)-katehina i kvercetina protiv gram-pozitivnih i gram-negativnih bakterija. Kad je reč o antitumorskim svojstvima uticaj ima antioksidativna aktivnost, regulacija proteina p53, inhibicija aktivnosti protein kinaza i apoptoza.

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2024/01/26
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