UPOREDNE FARMAKOKINETSKE KARAKTERISTIKE TAKROLIMUSA NAKON PRIMENE RAZLIČITIH FARMACEUTSKIH FORMULACIJA LEKA KOD LJUDI

Nemanja Rančić; Viktorija Dragojević-Simić

doi:10.5937/racter9-11560

Nemanja Rančić Centre for Clinical Pharmacology; Medical Faculty Military Medical Academy, University of Defence, Belgrade, Serbia
Viktorija Dragojević-Simić Centre for Clinical Pharmacology; Medical Faculty Military Medical Academy, University of Defence, Belgrade, Serbia

DOI: https://doi.org/10.5937/racter9-11560

Ključne reči: transplantation||, ||transplatacija, drug formulation||, ||farmaceutska formulacija, Tacrolimus||, ||takrolimus, Pharmacokinetics||, ||farmakokinetika,

Sažetak

Takrolimus je imunosupresivni lek koji predstavlja kamen temeljac u prevenciji odbacivanja grafta posle transplantacije solidnih organa. Nakon dugogodišnje upotrebe farmaceutske formulacije ovog leka koja se primenjuje dva puta dnevno, usledila je nova era primene takrolimusa sa produženim oslobađanjem, koji se primenjuje jednom dnevno. Cilj ovog kratkog literaturnog prikaza je da se sagledaju uporedo farmakokinetske karakteristike ovog leka nakon njegove primene u obliku kapsula dva puta na dan, na 12 sati, i farmaceutske formulacije sa produženim oslobađanjem, koja se dozira jednom dnevno u zdravih osoba i pacijenata. Međutim, tek buduće kliničke studije će pokazati da li su ove dve formulacije zaista uporedive što se tiče farmakokinetskih parametara, i, što je još važnije, u smislu dugotrajne bezbednosti takrolimusa sa produženim oslobađanjem, preživljavanja grafta i pacijenata.

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