AKUTNA RADIJACIONA TOKSIČNOST ZA VREME I POSLE HEMORADIOTERAPIJE KOD PACIJENTKINJA SA LOKALNO UZNAPREDOVALIM KARCINOMOM CERVIKSA UTERUSA
Sažetak
Karcinom cerviksa uterusa se nalazi na alarmantnom 4. mestu među malignim tumorima kod žena, i predstavlja globalni problem. Zlatni standard u lečenju lokalno uznapredovalog karcinoma cerviksa uterusa je hemoradioterapija (eksterno zračenje i brahiterapija). Međutim, za vreme lečenja karcinoma cerviksa uterusa nastaju različiti oblici akutne toksičnosti, koji uključuju oštećenja krvnih loza, gastrointestinalne, genitourinarne i dermatološke probleme.
Mada je većina potencijalnih faktora rizika za pojavu akutne radijacione toksičnosti vezana za pojedine modalitete terapije, treba uvek uzeti u obzir individualne karakteristike pacijenata. Poznavanje potencijalnih faktora rizika i rano otkrivanje pacijenata sa povećanim rizikom od akutne radijacione toksičnosti može značajno doprineti primeni adekvatnih korektivnih mera koje će sprečiti i akutnu i još kompleksniju hroničnu radijacionu toksičnost. Takav pristup dovodi i do poboljšanja kvaliteta života pacijenata sa lokalno uznapredovalim karcinomom cerviksa uterusa.
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