Sanamed

ASSESSMENT OF THE RELATIONSHIP BETWEEN SERUM TWEAK LEVELS AND THE DEGREE OF VASCULAR INVOLVEMENT IN PATIENTS WITH STABLE ANGINA PECTORIS

Vehbi Şirikçi, Hüseyin Avni Fındıklı, Savaş Öztürk — Sun, 28 Apr 2024 23:08:45 +0200

Introduction: This study investigates the relationship between serum TWEAK levels and the degree of vascular involvement in patients with stable angina pectoris, offering insights beyond conventional cardiovascular risk factors.

Materials and Methods: This study involved 88 patients (33 women, 55 men) diagnosed with stable angina pectoris. Patients were classified based on angiographic findings. Comprehensive demographic and medical history data were collected, and morning blood samples were analyzed, focusing on TWEAK and IL-6 levels. To assess the severity of coronary artery lesions, a modified version of the Gensini scoring system was employed.

Results: Analyses revealed no significant correlation between TWEAK levels and the severity of coronary artery disease. Although some variations in biochemical markers were observed based on gender and diabetic status, these differences did not exhibit a statistically significant relationship with the degree of vascular involvement.

Conclusion: The findings indicate that serum TWEAK levels do not have a significant association with the severity of vascular involvement in patients with stable angina pectoris. These results highlight the limited efficacy of TWEAK as a sole biomarker in assessing the severity of coronary artery disease, emphasizing the complexity of its role.

APPLICATION OF TRANSANAL TUBE AFTER ANTERIOR RECTAL RESECTION: IMPACT ON PREVENTION OF "ACHILLES HEEL" IN COLORECTAL SURGERY

Sun, 28 Apr 2024 23:09:28 +0200

Aim: The aim of our study was to investigate the potential reduction in the likelihood of anastomotic leakage occurrence in patients undergoing open anterior resection of the rectum without a protective stoma for stage III adenocarcinoma, by employing a transanal tube after performing stapled colorectal anastomosis.

Results: Considering the influence of all included risk factors, male gender (p=0.032; OR=2.873) and patients with type 2 diabetes mellitus (p=0.033; OR=2.873) demonstrated an increased likelihood of anastomotic leakage, while the presence of a transanal tube (p=0.043; OR=0.349; 95% CI: 0.126, 0.966) was associated with a statistically significant reduction in the likelihood of anastomotic leakage. T-test revealed that patients with anastomotic leakage without a placed tube had a statistically significantly longer mean postoperative hospitalization (20.94 days) compared to those with a transanal tube (19.43 days) (t=2.375; p=0.025). Kaplan-Meier analysis didn’t show a statistically significant difference in the average estimated time to the occurrence of anastomotic leakage between patients without (3.86 days) and with a transanal tube (4.58 days) (p=0.057).

Conclusion: Our study found that the placement of a transanal tube after colorectal anastomosis may be associated with a reduced likelihood of anastomotic leakage and shorter hospitalization in case leakage occurs. Additionally, although no statistically significant difference was found in the effect of the tube on the occurrence of anastomotic leakage depending on the presence of type 2 diabetes mellitus, the indication for its use in patients with type 2 diabetes mellitus may be of particular benefit.

SOFT LINING OF IMMEDIATE COMPLETE DENTURES: CASE REPORT

Sun, 28 Apr 2024 23:07:40 +0200

Introduction: With the placement of dental implants in edentulous patients, creating and adapting immediate dentures is crucial to allow patients to perform basic physiological functions during the osseointegration period without affecting implant healing. This report presents a case of direct soft lining of immediate complete dentures following implant placement.

Case Report: Six dental implants were inserted in the upper jaw, while the patient retained natural teeth in the lower jaw. An immediate complete denture was fabricated and adjusted for the upper jaw. The prosthesis base was prepared and processed to accommodate soft lining material. Adhesive was applied to the prepared base, followed by silicone application for soft fitting onto the prosthesis base, which was then inserted into the patient's mouth. After three minutes, the denture was removed, and soft lining treatment of the immediate complete denture was completed.

Conclusion: Direct soft lining facilitated patient adaptation to the immediate prosthesis and supported safer healing and osseointegration until definitive work could be completed. The addition of a soft silicone layer reduced pressure on the residual alveolar ridge and improved adhesion of the immediate prosthesis.

IMPACT OF VITAMIN E ON DIFFERENT ORGAN SYSTEMS

Marko Koprivica, Ana Miljković — Wed, 24 Apr 2024 11:42:50 +0200

Vitamin E, present in both plant and animal-based foods, is a lipophilic compound with multifaceted biochemical functions. Its deficiency can lead to severe health consequences, while excessive intake may result in hypervitaminosis. Among tocopherols, Alpha-tocopherol stands out for its pharmacokinetic properties and potent antioxidant effects. It exerts significant influence on the immune, nervous, and cardiovascular systems, as well as on skin health. Notably, it plays a crucial role in preventing carcinogenesis. While Alpha-tocopherol garners attention, other tocopherol group members should not be overlooked, as advancements in science uncover their diverse biological impacts. In recent years, tocotrienols have emerged with distinct biochemical properties that profoundly affect human health.