HODGKIN’S LYMPHOMA IN PREGNANCY: CASE REPORT AND REVIEW OF LITERATURE
Abstract
Introduction/Objective: The incidence of Hodgkin lymphoma (HL) is high during the reproductive years, making the occurrence of this malignancy during pregnancy a significant issue in everyday clinical practice. The aim is to present a case study demonstrating the characteristics of clinical courses and analyze published data through a literature review.
Case report: A 33-year-old pregnant woman in her third trimester developed neck swelling, night sweats, itching, and weight loss. Ultrasound examination revealed significant lymphadenopathy in the supraclavicular region. Surgical excision of the lymph node and pathological verification confirmed the diagnosis of Hodgkin lymphoma. Given the pregnancy and the limited use of radiographic diagnostics, magnetic resonance imaging (MR) was performed and confirmed generalized lymphadenopathy with resultant hydronephrosis of the right kidney. After diagnosing advanced-stage HL, it was decided to initiate specific hematologic treatment with chemotherapy. Delivery was carried out at 37 weeks of gestation via vaginal delivery, with no complications for the mother or newborn. Following delivery, a complete disease reevaluation was conducted, and it was decided to continue treatment with a total of six cycles of chemotherapy according to the ABVD (adriamycin, bleomycin, vinblastine, dacarbazine) protocol. After six cycles of chemotherapy, metabolic remission of the disease was achieved.
Conclusion: Managing Hodgkin lymphoma during pregnancy presents a complex challenge requiring a coordinated multidisciplinary approach and a personalized treatment plan.
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