Spectrophotometric method in comparative in vitro dissolution test of branded and generic ibuprofen tablets

Ana Marković; Miroslava Spasić; Vesna Savić; Slavica Sunarić; Marija Tasić Kostov

doi:10.5937/afmnai38-28337

Ana Marković KUniverzitet u NišuMedicinski fakultet NišKatedra Farmacija
Miroslava Spasić
Vesna Savić
Slavica Sunarić
Marija Tasić Kostov

DOI: https://doi.org/10.5937/afmnai38-28337

Keywords: dissolution test, ibuprofen, bioequivalence, generic drug, branded drug

Abstract

Dissolution test is a simple and important in vitro method for assessing bioequivalence of drugs. It implies the use of proper analytical method, and high-performance liquid chromatography (HPLC) is widely used. Spectrophotometry could be a significant substitute, through clear advantages in terms of simplicity and costs of analysis. In the present study, possible differences in bioavailability between branded and generic ibuprofen coated tablets were predicted using dissolution test for solid dosage forms. The ibuprofen content and the amount of ibuprofen released in the dissolution test were determined using a simple and accurate spectrophotometric method. Based on the obtained results, no significant differences in the dissolution rate of ibuprofen from generic and branded coated tablets were observed. It can be concluded that the spectrophotometric method applied for the dissolution test could be used for bioequivalence screening in conditions where rapid and simple assessment is required or where HPLC is not available.

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