ANALIZA LABORATORIJSKIH PARAMETARA HRONIČNE BUBREŽNE INSUFICIJECIJE KOD STARIJIH BOLESNIKA

Edhem  Hasković; Harun Uzunalić; Snežana Unčanin; Safija Herenda; Denis Hasković; Amina  Selimović

doi:10.5937/afmnai39-34954

Edhem Hasković
Harun Uzunalić
Snežana Unčanin
Safija Herenda University of Sarajevo, Faculty of Science, Department of Chemistry
Denis Hasković
Amina Selimović

DOI: https://doi.org/10.5937/afmnai39-34954

Ključne reči: starija životna dob, hronična bubrežna bolest, GFR, proteinurija

Sažetak

Cilj: Osnovni cilj ovog istraživanja je praćenje laboratorijskih parametara hronične bubrežne insuficijencije kod starijih pacijenata.

Materijali i metode: Svi uzorci su uzeti i obrađeni standardnim metodama i u skladu sa principima dobre laboratorijske prakse. Podaci su prikupljeni organizovano i sistematski u vidu upitnika u skladu sa etičkim principima i kao takvi analizirani statističkim testovi i analize (Student t test, analiza varijanse - ANOVA, Pirsonov i Spirmanov koeficijent korelacije). Granica statističke značajnosti je P <0,05.

Rezultati: Srednje vrednosti klirensa kreatinina i proteinurije za ukupnu ispitivanu populaciju su bile: 41,30±21,43 mL/min, 1,5±2,3 g/L/24h respektivno. Hematološki parametri nisu pokazali znatne razlike u odnosu na normalne vrednosti. Učestalost hipertenzije i dijabetesa kod ispitanika odgovara podacima iz literature. Najveća učestalost komorbiditeta je uočena kod ispitanika sa ≥80 godina sa prosekom od 2,03 komorbiditeta po ispitaniku. Vrednosti serumskog kreatinina i uree kao i klirensa kreatinina su dobar pokazatelj progresije bolesti.

Zaključak: Rezultati prikazanog istraživanja upućuju na to da je starost predisponirajući faktor rizika za nastanak hronične bolesti bubrega, te da u kombinaciji sa komorbiditetima (hipertenzija i/ili dijabetes) doprinosi lošoj prognozi ili progresiji bolesti.

Reference

1. United Nations, Department of Economic and Social Affairs, Population Division. World Population Prospects: The 2017 Revision, Key Findings and Advance Tables. New York, 2017. No. ESA/P/WP/248.
2. Jurić I. Incidence of risk factors for the development of chronic renal failure in elderly patients. [dissertation]. University of Zagreb; 2015.
3. Duraković Z. Aging. Periodicum Biologorum. 2013;115(4):491-498.
4. Parmar MS. Chronic renal disease. British Medical Journal. 2002;325:85-9.
5. Stevens PE, Levin A. Kidney Disease: Improving Global Outcomes Chronic Kidney Disease Guideline Development Work Group Members. Evaluation and management of chronic kidney disease: synopsis of the kidney disease: improving global outcomes 2012 clinical practice guideline. Annals if Internal Medicine.2013;158(11):825-830.
6. Levey A, Coresh J. Chronic kidney disease. Lancet.2012; 379 (9811):165-180.
7. Romagnani P, et al. Chronic kidney disease. Nature Reviews Disease Primers. 2017;Nov 23;3:17088.
8. Jha V, et al. Chronic kidney disease: global dimension and perspectives. Lancet. 2013; 382:260-272.
9. Rački S, Orlić L, Sladoje-Martinović B. Chronic renal failure - an indication for kidney transplantation. Medix. 2011;17(92/93):195-201.
10. Drawz P, Rahman M. Chronic kidney disease. Annals of Internal Medicine. 2015;162(11): ITC1- 16.
11. Radišić Biljak V, et al. The role of laboratory testing in detection and classification of chronic kidney disease: national recommendations. Biochemia Medica. 2017; 27(1):153-176.
12. Abdulkader RCRM, et al. Aging and decreased glomerular filtration rate: An elderly population-based study. PLoS ONE. 2017;12(12): e0189935.
13. Goldberg I, Krause I. The role of gender in chronic kidney disease. European Medical Journal.2016;1(2):58-64.
14. Norris KC, et al. Albuminuria, serum creatinine and estimated glomerular filtration rate as predictors of cardio-renal outcomes in patients with type 2 diabetes mellitus and kidney disease: a systematic literature review. BMC Nephrology. 2018;19(36)
15. McClure M. et al. Elderly patients with chronic kidney disease: do they really need referral to the nephrology clinic? Clinical Kidney Journal. 2017;10 (5):698-702.
16. Iimori S. et al. Prognosis of chronic kidney disease with normal-range proteinuria: The CKD-ROUTE study. PLoS ONE.2018;13(1).
17. Treacy O, Brown NN, Dimeski G. Biochemical evaluation of kidney disease. Translaional Andrology and Urology.2019;8(2),214-223.
18. Higgins C. Urea and the clinical value of measuring blood urea concentration. Oncortarget 2016; 7(34): 55863-55889.
19. Bhagyalakshmi A, et al. Role od urine sediment cytology in the diagnosis of renal disorders in comparison with biochemical and histopathological findings. International Journal of Research in Medical Sciences. 2014; 2(2):560-568.
20. Shastry I, Belurkar S. The spectrum of red blood cell parameters in chronic kidney disease: A study of 300 cases. Journal of Applied Hematology. 2019;10(2):61-66.