ULOGA INTERLEUKINA-8 U RAZVOJU I KLINIČKOJ PROGRESIJI HRONIČNIH PERIAPEKSNIH LEZIJA
IL-8 u periapeksnim lezijama
Sažetak
Uvod/cilj: Hronični apeksni parodontiti predstavljaju dinamičku reakciju na prisustvo endodontske infekcije u sistemu kanala korena zuba kada dolazi do aktivacije urođenog i stečenog imunog odgovora i regrutovanja različitih ćelija i inflamatornih medijatora koji će izazvati posledičnu destrukciju periapeksnih tkiva i formiranje periapeksne lezije. Cilj studije je bio da se odredi koncentracija IL-8 u homogenatima tkiva periapeksnih lezija i da se dobijeni rezultati uporede sa simptomatologijom pacijenata i veličinom lezije.
Materijal i metode: Analizirano je 93 uzoraka hroničnih periapeksnih lezija dobijenih nakon ekstrakcije zuba. Uzorci su prema kliničkim simptomima bili podeljeni na simptomatske i asimptomatske, i u odnosu na veličinu na velike i male lezije. Koncentracija IL-8 je analizirana pomoću ELISA testa.
Rezultati: Rezultati su pokazali statistički značajno veću koncentraciju IL-8 u simptomatskim periapeksnim lezijama u poređenju sa asimptomatskim (p<0,001). Statistički značajna razlika u koncentracijama ovog hemokina je uočena u poređenju grupe velikih lezija u odnosu na male (p<0,001).
Zaključak: Veća koncentracija IL-8 u u lezijma sa izraženim kliničkim simptomima, kao i u velikim lezijama ukazuje da je IL-8 važan hemokin koji doprinosi razvoju inflamacije i kliničkoj progresiji periapeksnih lezija.
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