Сlinical and simple laboratory data associated with fatal outcomes in patients with acute pancreatitis

Tetiana Formanchuk; Volodymyr Shaprinskiy; Andrii  Formanchuk

doi:10.5937/afmnai39-32308

Dr. Tetiana Formanchuk National Pirogov Memorial Medical University, Vinnytsya https://orcid.org/0000-0002-9565-8213
Prof. Volodymyr Shaprinskiy National Pirogov Memorial Medical University, Vinnytsya https://orcid.org/0000-0002-3890-6217
Dr. Andrii Formanchuk National Pirogov Memorial Medical University, Vinnytsya https://orcid.org/0000-0003-4676-1289

DOI: https://doi.org/10.5937/afmnai39-32308

Keywords: acute pancreatitis, mortality, clinical data, simple laboratory data

Abstract

Aims. Our study was aimed to evaluate assoсiation of mortality in acute pancreatitis with clinical and simple laboratory data received in the day of admission. Material and methods. In our retrospective study, the clinical and laboratory parameters of 99 patients with moderate and severe acute pancreatitis were analyzed. All patients were divided into two groups: deceased and survivors. Results. We did not find a significant difference in age and gender distribution between the comparison groups. However, a significant predominance of alcoholic etiology of acute pancreatitis, early hospitalization (up to 6 hours from the onset of the disease) of patients, the number of necrotizing infected type in the deceased group was found. Concomitant pathology did not significantly differ in comparison groups. In patients from the deceased group the total number of all complications was significantly higher, than in the group of survivors – 21 (100%) and 42 (53.8%) (p = 0.0001). Among the laboratory parameters in the deceased group there was a significant increase in stabs to 19.8 ± 9.8 and ESR, AST to 225.3 ± 47.5 U/L, urea to 11.2 ± 7.7 mmol/L and creatinine to 173.6 ± 26.1 mkmol/L. Conclusion. Alcoholic genesis of acute pancreatitis, necrotising infected type of inflammation of the pancreas, presence of late complications and comorbidities were significantly higher in the deceased group. The levels of stabs, ESR, AST, urea, creatinine determined at the admission significantly dominated in the deceased group and need further study for the prediction of mortality of acute pancreatitis.

Author Biographies

Dr. Tetiana Formanchuk, National Pirogov Memorial Medical University, Vinnytsya

Associate Professor, Department of surgery №2 with course of basic stomatology

Prof. Volodymyr Shaprinskiy, National Pirogov Memorial Medical University, Vinnytsya

Professor, a head of department of surgery №1 with course of urology

Dr. Andrii Formanchuk, National Pirogov Memorial Medical University, Vinnytsya

Associate Professor of the Department of surgery №1 with course of urology

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