Melatonin corrective effect on systemic and vascular hemodynamics parameters in patients with the first degree of arterial hypertension suffering from insomnia

Abstract

Sleep disturbance is a common reason for seeking primary health care providers` medical attention and is the first manifestation of arterial hypertension (AH) at the disease onset. An uncontrolled blood pressure (BP) increase aggravates the course of physiological processes and increases cardiovascular complication (CVC) risk, even with a short AH duration. Additional prescription of an adaptogen as a physiological regulator of circadian biorhythms in patients with early AH and insomnia stages is justified. The aim of the work is to study features of central and vascular hemodynamics in patients with the 1st degree of AH. The changes identified indicated a significant activity of the renin-angiotensin-aldosterone system (RAAS), hypersympathicotonia at night, and desynchronosis caused by melatonin (MT) secretion deficiency. Рharmacotherapy with synthetic MT analogue inclusion into the treatment regimen for patients with AH and insomnia was accompanied by a significant improvement in the clinical condition. The target BP level was achieved in most patients, as well as a positive dynamics of central BP parameters and regression of indicators reflecting peripheral arteries rigidity.