A Identification of ELOVL3 as a novel prognostic marker for liver cancer based on fatty acid metabolism genes associated with liver cancer prognosis
biomarker for liver cancer
Abstract
Abstract
Background: The incidence of liver cancer is increasing globally. Fatty acids in lipid metabolism are associated with cancer risk by maintaining cancer cell membrane structure and transducing cancer signaling, and their increased synthesis promotes tumor growth, angiogenesis, and tumor metastasis.
Methods: After obtaining the fatty acid metabolism gene ELOVL3 gene related to the prognosis of liver cancer, its expression level was extracted from the TCGA database, and differential analysis, survival analysis, clinical correlation analysis and nomogram were used to predict its survival rate. A comprehensive meta-analysis was performed to further evaluate the prognostic value of ELOVL3. Finally, enrichment analysis and immune analysis were performed on the high and low expression groups of ELOVL3 gene. To explore the value of ELOVL3 in predicting the prognosis and immunotherapy of liver cancer patients.
Results: Patients with high ELOVL3 expression had poor overall survival and progression-free survival. The nomogram and the area under the ROC curve also indicated that the expression of ELOVL3 gene had high accuracy in predicting the survival time of liver cancer patients. The expression of ELOVL3 was significantly different in the early stage of tumor grade, tumor stage and T stage. Enrichment analysis, immunological analysis revealed a variety of information. The immunotherapy analysis also showed that low ELOVL3 was more effective than high ELOVL3 when receiving immunotherapy.
Conclusion: The expression of ELOVL3 gene is significantly elevated in HCC and is associated with cancer development and poor prognosis.
References
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