Evaluation of Serum Level of Anti-Müllerian Hormone in Pre-eclampsia

Wasan  Wajdi; Ishraq Mohammed; Raghad Nabeel  Al-Khayyat

doi:10.5937/afmnai42-55303

Wasan Wajdi Department of obstetrics and gynecology, college of medicine, university of Baghdad, Baghdad ,Iraq.
Ishraq Mohammed Department of obstetrics and gynecology , college of medicine , university of Baghdad , Baghdad ,Iraq.
Raghad Nabeel Al-Khayyat Department of obstetrics and gynecology, Medical City, Ministry of Health , Baghdad , Iraq .

DOI: https://doi.org/10.5937/afmnai42-55303

Keywords: anti-mullerian hormone, pre-eclampsia, blood pressure

Abstract

Background: Pre-eclampsia is a multiorgan disease process characterized by hypertension and proteinuria after 20 weeks of gestation.

Aim of the study: To assess serum level of anti-müllerian hormone (AMH) in pregnant women as predictor for pre-eclampsia.

Patients and method: A case control study was carried out in Baghdad Teaching Hospital from 2020 to 2021. A sample of 192 pregnant women within the 3rd trimester participated and divided into two main groups. The first group enrolled 96 normotensive pregnant women (control group), and a second group included 96 patients with pre-eclampsia as (case group). The latter group was subdivided into 36 patients with mild to moderate pre-eclampsia, and 60 with severe pre-eclampsia. Blood samples were taken from each woman (case and control) to test AMH level, liver function tests, renal function tests, s.uric acid, s.lactate dehydrogenase (LDH) and complete blood picture. Urine samples were sent for albumin and spot urine for protein/ creatinine ratio.

Results: AMH levels were significantly lower in case group than in control group (P<0.001). In control group, AMH level was (4.92 ± 1.79) ng/ml, while for mild to moderate pre-eclampsia group was (1.56 ± 0.21) ng/ml, and (0.42±0.38) ng/ml for sever pre-eclampsia. Systolic and diastolic blood pressure showed significant higher values in case group (P<0.001). Gestational age, serum uric acid and serum albumin have moderate correlation with AMH in pre-eclampsia with significant association.

Conclusion: The level of AMH was decreased significantly in pregnant women with pre-eclampsia in comparison to healthy pregnancy.