Teksturna i senzorna karakterizacija karbomernih gelova sa pantenolom
Sažetak
Cilj ove studije bio je da se proceni uticaj koncentracije karbomera, gelirajućeg sredstva (primenjenog u koncentracijskom rasponu 0,5-2,0%) na teksturne i senzorne karakteristike gelova sa 3% pantenola, pomoću senzorne analize kao subjektivne i teksturne analize kao objektivne metode procene. Aktivna supstanca u gelovima bio je pantenol, koji je takođe delovao i kao sredstvo za neutralizaciju karbomera. Dvadeset panelista ženskog pola, starosti između 20 i 36 godina, učestvovalo je u senzornoj studiji u kojoj sе popunjavaо upitnik s pitanjima u vezi aplikativnih svojstava gelova pre, tokom i nakon nanošenja na kožu. Analiza teksture je izvršena na CT3 Texture Analyzer-u, nakon svake nedelje tokom mesec dana, a izmereni su sledeći parametri: čvrstoća nakon 1. ciklusa, čvrstoća nakon 2. ciklusa, kohezivnost, adhezivnost, rezilijentnost i elastičnost. Rezultati su pokazali da su tokom trajanja studije gelovi bili stabilni i da je struktura gela ostala očuvana bez obzira na kompresiju. Povećanje tvrdoće i rezilijentnosti pratilo je povećanje koncentracije karbomera, dok se adhezivnost, kohezivnost i elastičnost nisu mnogo razlikovali među ispitivanim gelovima. Isti trend primećen je i kada su gelovi upoređivani tokom vremena. Senzorna analiza potvrdila je nalaze teksturne analize i pokazala da se sa porastom koncentracije karbomera, lepljivost i gustina takođe povećavaju, dok se brzina apsorpcije i razmazivost smanjuju. Većina panelista odabrala je gel sa 1% karbomera kao gel koji bi redovno koristili. Teksturne i senzorne metode predstavljaju dragoceni pristupi prilikom dizajniranja lekova/kozmetičkih proizvoda, jer pružaju uvid u komplijansu pacijenata/korisnika.
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