Mikro RNK - potencijalni biomarkeri hronične bolesti bubrega
Sažetak
Uvod: Standardni biomarkeri za dijagnozu i praćenje hronične bolesti bubrega nisu u potpunosti adekvatni ni u ranoj dijagnozi, adekvatnom praćenju i proceni progresije, ni u proceni rizika od razvoja komplikacija. Iz tog razloga, potraga za novim, pogodnijim biomarkerima je stalna. Mnogo studija preporučuje mikro RNK kao potencijalno rešenje, s obzirom da su uključene u patogenezu dijabetesne nefropatije, tumora bubrega i poremećaja funkcije bubrega uopšte.
Metode: Korišćeni su internet pretraživači za selekciju adekvatne literature i podataka, kao i elektronskih baza podataka.
Rezultati: Istraživanja publikovana do sada, naročito u oblasti onkologije, navode različite pojedinačne i panele mikro RNK kao kandidate za uvođenje u rutinsku dijagnostiku. Hronična bolest bubrega je, naime, prilično kompleksna u smislu etiologije pojave bolesti, s obzirom da mnogo različitih uzroka može da dovede do oštećenja bubrežnog tkiva i poremećaja bubrežne funkcije i, konačno, do potpunog razvoja hronične bubrežne bolesti. Mikro RNK su stabilne u telesnim tečnostima i proces hemodijalize ne utiče na njihov nivo. Takođe, visoka aktivnost RNaza kod pacijenata sa hroničnom bubrežnom bolešću ne ubrzava degradaciju mikro RNK u njihovim uzorcima.
Zaključak: Literaturni podaci ukazuju da bi mikro RNK mogle da budu pogodni kandidati za dijagnostičku primenu u hroničnoj bubrežnoj bolesti. Ipak, i dalje postoje izazovi koji moraju biti prevaziđeni za uvođenje mikro RNK u rutinsku upotrebu.
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