KORELACIONA ANALIZA LUTEINIZIRAJUĆIH I SOMATOTROPNIH ĆELIJA HIPOFIZE KOD MUŠKIH KADAVERA TOKOM STARENJA
Sažetak
U fokusu ovog rada bilo je ispitivanje korelacije imunoreaktivnih luteinizirajućih (LH) i imunoreaktivnih somatotropnih (GH) ćelija kod muških kadavera tokom starenja. Anti-LH i anti-GH antitela obeležila su gorepomenute ćelije hipofize kod 14 muških kadavera. Ćelije identifikovane na ovaj način analizirane su sistemom ImageJ. Dobijeni rezultati statistički su analizirani pomoću statističkog softverskog paketa SPSS. Rezultati morfometrijske analize pokazali su da se tokom starenja površina LH i GH ćelija značajno povećala (p < 0,05), da se nuklearno-citoplazmatski odnos smanjio, kao i da su dobijene promene bile od posebnog značaja (p < 0,05) kod kadavera muškaraca starijih od 70 godina. Ovakvi rezultati ukazali su na to da je nakon 70. godine starosti došlo do hipertrofije ispitivanih ćelija. Nastale promene bile su funkcionalne prirode i pokazale su da je hormonski kapacitet bio značajno smanjen kod kadavera muškaraca koji su imali više od 70 godina. Na osnovu navedenog, može se zaključiti da ispitivani morfometrijski parametri gonadotropnih LH i GH ćelija značajno koreliraju, što može upućivati na paralelnu pojavu adaptacionih i kompenzacionih mehanizama u pomenutim ćelijama kod muškaraca u procesu starenja.
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