PROPOLIS: CHEMICAL COMPOSITION, BIOLOGICAL AND PHARMACOLOGICAL ACTIVITY – A REVIEW

Sanja T Stojanović; Stevo J Najman; Biljana Bogdanova Popov; Svetozar S Najman

Sanja T Stojanović University of Niš, Faculty of Medicine, Department of Biology and Human Genetics
Stevo J Najman University of Niš, Faculty of Medicine, Department of Biology and Human Genetics
Biljana Bogdanova Popov University St. Kliment Ohridski - Bitola, E.S. Gjorgji Sugarev - Bitola, 7000 Bitola, R. N. Macedonia
Svetozar S Najman University of Niš, Faculty of Medicine, 18000 Niš, Serbia

Abstract

Propolis is a honey bee product that is well known from ancient times for its beneficial effects on human health and has been widely used in traditional medicine. Chemical composition of propolis is very complex and rich which is why propolis has many biological activities, but is dependent on the geographical origin and plant sources from which bees collect it. Despite great diversity of its chemical composition, propolis has many biological and pharmacological activities and is widely used in medicine, dentistry and pharmacy. In this review, beneficial effects of propolis through its biological and pharmacological activities are discussed.

Author Biographies

Sanja T Stojanović, University of Niš, Faculty of Medicine, Department of Biology and Human Genetics

Dr Sanja Stojanović, teaching assistant

Department of Biology and Human Genetics, Faculty of Medicine, University of Niš

Stevo J Najman, University of Niš, Faculty of Medicine, Department of Biology and Human Genetics

Prof. dr Stevo Najman

Faculty of Medicine, University of Niš

References

Simone-Finstrom M, Spivak M. Propolis and bee health: the natural history and significance of resin use by honey bees. Apidologie 2010; 41:295–311.

Kuropatnicki AK, Szliszka E, Krol W. Historical aspects of propolis research in modern times. Evid Based Complement Alternat Med 2013; 2013:964149.

Pujirahayu N, Suzuki T, Katayama T. Cycloartane-Type Triterpenes and Botanical Origin of Propolis of Stingless Indonesian Bee Tetragonula sapiens. Plants (Basel) 2019; 8(3): E57.

Bankova VS, De Castro SL, Marcucci MC. Propolis: recent advances in chemistry and plant origin. Apidologie 2000; 31:3–15.

Bankova V. Chemical diversity of propolis and the problem of standardization. J Ethnopharmacol 2005; 100(1-2):114-7.

Martinotti S, Ranzato E. Propolis: a new frontier for wound healing? Burns Trauma 2015; 3:9.

Suryati Mohd K, Elani Mat Nafi N, Shafiqha Abdul Khadar A, Awanis Mohd Badiazaman A, Rani Annisava A. Propolis: Traditional uses, Phytochemical Composition and Pharmacological Properties. International Journal of Engineering & Technology 2018; 7(4.43), 78-82.

Bogdanov S. Propolis: Composition, Health, Medicine: A Review. 2012; Available from: http://www.bee-hexagon.net/files/file/fileE/Health/PropolisBookReview.pdf.

Castaldo S, Capasso F. Propolis, an old remedy used in modern medicine. Fitoterapia 2002; 73(Suppl 1):S1-6.

Ristivojević P, Trifković J, Andrić F, Milojković-Opsenica D. Poplar-type Propolis: Chemical Composition, Botanical Origin and Biological Activity. Nat Prod Commun 2015; 10(11):1869-76.

Gómez-Caravaca A, Gómez-Romero M, Arráez-Román D, Segura-Carretero A, Fernández-Gutiérrez A. Advances in the analysis of phenolic compounds in products derived from bees. J Pharmaceut Biomed 2006; 41(4):1220–1234.

Huang S, Zhang C-P, Wang K, Li GQ, Hu F-L. Recent advances in the chemical composition of propolis. Molecules 2014; 19(12):19610–19632.

Sforcin JM. Biological Properties and Therapeutic Applications of Propolis. Phytother Res 2016; 30(6):894-905.

Pasupuleti VR, Sammugam L, Ramesh N, Gan SH. Honey, Propolis, and Royal Jelly: A Comprehensive Review of Their Biological Actions and Health Benefits. Oxid Med Cell Longev 2017; 2017:1259510.

Bankova V, Popova M, Trusheva B. Propolis volatile compounds: chemical diversity and biological activity: a review. Chem Cent J 2014; 8:28.

Madrigal-Santillán E, Madrigal-Bujaidar E, Álvarez-González I, Sumaya-Martínez MT, Gutiérrez-Salinas J, Bautista M, et al. Review of natural products with hepatoprotective effects. World J Gastroenterol 2014; 20(40):14787-14804.

Volpi N. Separation of flavonoids and phenolic acids from propolis by capillary zone electrophoresis. Electrophoresis 2004; 25(12):1872–1878.

Zabaiou N, Fouache A, Trousson A, Baron S, Zellagui A, Lahouel M, et al. Biological properties of propolis extracts: Something new from an ancient product. Chem Phys Lipids 2017; 207(Pt B):214-222.

Przybyłek I, Karpiński TM. Antibacterial Properties of Propolis. Molecules 2019; 24(11):E2047.

Lotfy M. Biological activity of bee propolis in health and disease. Asian Pac J Cancer P 2006; 7(1):22–31.

Cvek J, Medid-Saric M, Vitali D, Vedrina-Dragojevik I, Smit Z, Tomic S. The content of essential and toxic elements in Croatian propolis samples and their tinctures. J Apicult Res 2008; 47:35–45.

Alberti T, Coelho D, Voytena A, Iacovski R, Mazzarino L, Maraschin M, et al. Effect of Propolis Nanoparticles on Early-Stage Wound Healing in a Diabetic Noncontractile Wound Model. Nanotechnol Adv Mater Sci 2019; 2(1):1–10.

Sforcin JM, Bankova V. Propolis: Is there a potential for the development of new drugs? J Ethnopharmacol 2011; 133:253–260.

Banskota AH, Tezuka Y, Kadota S. Recent progress in pharmacological research of propolis. Phytother Res 2001; 15(7):561-71.

Farooqui T, Farooqui AA. Beneficial effects of propolis on human health and neurological diseases. Front Biosci (Elite Ed) 2012; 4:779-93.

Ahmed R, Tanvir EM, Hossen MS, Afroz R, Ahmmed I, Rumpa NE, et al. Antioxidant Properties and Cardioprotective Mechanism of Malaysian Propolis in Rats. Evid Based Complement Alternat Med 2017; 2017:5370545.

Zakerkish M, Jenabi M, Zaeemzadeh N, Hemmati AA, Neisi N. The Effect of Iranian Propolis on Glucose Metabolism, Lipid Profile, Insulin Resistance, Renal Function and Inflammatory Biomarkers in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blind Clinical Trial. Sci Rep 2019; 9(1):7289.

de Figueiredo SM, Nogueira-Machado JA, Almeida Bde M, Abreu SR, de Abreu JA, Filho SA, et al. Immunomodulatory properties of green propolis. Recent Pat Endocr Metab Immune Drug Discov 2014; 8(2):85-94.

Kim HB, Yoo BS. Propolis Inhibits UVA-Induced Apoptosis of Human Keratinocyte HaCaT Cells by Scavenging ROS. Toxicol Res 2016; 32(4):345-351.

El Menyiy N, Al Waili N, Bakour M, Al-Waili H, Lyoussi B. Protective Effect of Propolis in Proteinuria, Crystaluria, Nephrotoxicity and Hepatotoxicity Induced by Ethylene Glycol Ingestion. Arch Med Res 2016; 47(7):526-534.

Yuluğ E, Türedi S, Yıldırım Ö, Yenilmez E, Aliyazıcıoğlu Y, Demir S, et al. Biochemical and morphological evaluation of the effects of propolis on cisplatin induced kidney damage in rats. Biotech Histochem 2019; 94(3):204-213.

Nna VU, Bakar ABA, Mohamed M. Malaysian propolis, metformin and their combination, exert hepatoprotective effect in streptozotocin-induced diabetic rats. Life Sci 2018; 211:40-50.

Oršolić N, Landeka Jurčević I, Đikić D, Rogić D, Odeh D, Balta V, et al. Effect of Propolis on Diet-Induced Hyperlipidemia and Atherogenic Indices in Mice. Antioxidants (Basel) 2019; 8(6):E156.

Patel S. Emerging Adjuvant Therapy for Cancer: Propolis and its Constituents. J Diet Suppl 2016; 13(3):245-68.

Chan GC, Cheung KW, Sze DM. The immunomodulatory and anticancer properties of propolis. Clin Rev Allergy Immunol 2013; 44(3):262-73.

Liang Y, Feng G, Wu L, Zhong S, Gao X, Tong Y, et al. Caffeic acid phenethyl ester suppressed growth and metastasis of nasopharyngeal carcinoma cells by inactivating the NF-κB pathway. Drug Des Devel Ther 2019; 13:1335–1345.

Omene CO, Wu J, Frenkel K. Caffeic acid phenethyl ester (CAPE) derived from propolis, a honeybee product, inhibits growth of breast cancer stem cells. Investig New Drugs 2012; 30:1279–1288.

Medjeber O, Touri K, Rafa H, Djeraba Z, Belkhelfa M, Boutaleb AF, et al. Ex vivo immunomodulatory effect of ethanolic extract of propolis during Celiac Disease: involvement of nitric oxide pathway. Inflammopharmacology 2018; 26(6):1469-1481.