OVARIAN CANCER INCIDENCE TREND IN THE NIŠAVA DISTRICT
Abstract
Ovarian cancer represents the third most common gynecological cancer worldwide, and the most lethal one. The aim of the study was to assess ovarian cancer incidence trend in Nišava District in the period 1999-2017. Descriptive epidemiological method was applied. Data used for analyses were provided by the Cancer Register of the Institute of Public Health Niš and from the Serbian Cancer Registry. Incidence trends were based on crude and age-standardized incidence rates, calculated by the direct method of standardization per 100,000. Ovarian cancer represented 5.1% of all new registered malignant diseases in females with a total of 791 new cases. Ovarian cancer cases didn‘t registered before the age of 15. A statistically significant increasing trend with aging was registered. The average annual crude incidence rate was 22.0/100,000, while the average age-standardized incidence rate was 13.3/100,000. The highest age-standardized incidence rate was registered in 2016 (20.4), while the lowest rate was reported in 2002 (10.1). Ovarian cancer incidence trend, based on crude incidence rates, as well as on age-standardized incidence rates, increased. The highest age-adjusted incidence rate was in the municipality of Svrljig (18.4) and Gadžin Han (14.0) and the lowest registered in the municipality of Merošina (7.4) and Doljevac (9.0). Registration of unfavorable incidence trends of the disease indicate failure in primary and secondary prevention in the past. It is of vital importance to provide much intensive and comprehensive activities that may lead to the reduction of risk factors and to early detection of the disease.
References
Alberg AJ, Moorman PG, Crankshaw S, Wang F, Bandera EV, Barnholtz-Sloan JS, et al. Socioeconomic status in relation to the risk of ovarian cancer in African-American Women:a population-based case-control study. Am J Epidemiol 2016;184(4):274-83. [CrossRef] [PubMed]
Antonijevic A, Rancic N, Ilic M, Tiodorovic B, Stojanovic M, Stefanovic J. Incidence and mortality trends of ovarian cancer in central Serbia. JBUON 2017;22(2):508-12. [PubMed]
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018;68 (6): 394-424. [CrossRef] [PubMed]
Bray F, Loos AH, Tognazzo S, La Vecchia C. Ovarian cancer in Europe: crosssectional trends in incidence and mortality in 28 countries, 1953-2000. Int J Cancer 2005;113(6):977-90. [CrossRef] [PubMed]
Coburn S, Bray F, Sherman M, Trabert B. Interna-tional patterns and trends in ovarian cancer incidence, overall and by histologic subtype. Int J Cancer 2017; 140(11):2451-60. [CrossRef] [PubMed]
Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J Rosso S, Coebergh JW, Comber H, et al. Cancer incidence and mortality patterns in Europe:estimates for 40 countries in 2012. Eur J Cancer 2013;49:1374-403. [CrossRef] [PubMed]
Isherwood A, Bamford J, Dupuy AV. Ovarian cancer in select EU countries: incidence, treatable populations and sales by key drug class. Rev Epidemiol Sante Publique 2018;66:S286. [CrossRef]
Lowe KA, Chia VM, Taylor A, O'Malley C, Kelsh M, Mohamed M, et al. An international assessment of ovarian cancer incidence and mortality. Gynecol Oncol 2013;130(1):107-14. [CrossRef] [PubMed]
Momenimovahed Z , Tiznobaik A, Taheri S, Salehiniya H. Ovarian cancer in the world: epidemiology and risk factors. Int J Womens Health 2019;11:287-99. [CrossRef] [PubMed]
Praestegaard C, Kjaer SK, Nielsen TS, Jensen SM, Webb PM, Nagle CM, et al. The association between socioeconomic status and tumour stage at diagnosis of ovarian cancer: A pooled analysis of 18 case-control studies. Cancer Epidemiol 2016;41:71-9. [CrossRef] [PubMed]
Rahmani K, Moradi-Lakeh M, Mansori K, Bidokhti F, Asadi-Lari M. Global inequalities in incidence and mortality of ovarian cancer and associated factors: an ecological study. Alzheimers Park Res Ther 2018; 1: 1001.
Razi S, Ghoncheh M, Mohammadian-Hafshejani A, Aziznejhad H, Mohammadian M, Salehiniya H. The incidence and mortality of ovarian cancer and their relationship with the human development index in Asia. Cancermedicalscience 2016;10:628. [CrossRef] [PubMed]
Yoneda A, Lendorf ME, Couchman JR, Multhaupt HA. Breast and ovarian cancers: a survey and possible roles for the cell surface heparan sulfate proteo-glycans. J Histochem Cytochem 2012;60(1):9-21. [CrossRef] [PubMed]
Zhang Y, Luo G, Li M, Guo P, Xiao Y, Ji H, et al. Global patterns and trends in ovarian cancer incidence: age, period and birth cohort analysis. BMC Cancer 2019; 19:984. [CrossRef] [PubMed]