PERSONALIZED TREATMENT OF OBSTRUCTIVE SLEEP APNEA: IS IT STILL A LONG WAY OFF?

Zoran Stamenković; Lidija Ristic; Tatjana  Pejcic; Hristina Jovanovic; Hristina Trajkovic; Marko Bjelakovic; Jelena Cvetkovic; Ivan Matejic

Zoran Stamenković Klinika za plućne bolesti UKC Niš
Lidija Ristic Clinic for lung diseases, University clinical center Nis, Serbia; Department of internal medicine, Faculty of Medicine, University of Nis, Serbia
Tatjana Pejcic Clinic for lung diseases, University clinical center Nis, Serbia; Department of internal medicine, Faculty of Medicine, University of Nis, Serbia
Hristina Jovanovic Department for pharmacology and toxicology , Faculty of Medicine, University of Nis, Serbia
Hristina Trajkovic Department for pharmacology and toxicology , Faculty of Medicine, University of Nis, Serbia
Marko Bjelakovic Clinic for lung diseases, University clinical center Nis, Serbia
Jelena Cvetkovic Clinic for lung diseases, University clinical center Nis, Serbia
Ivan Matejic Clinic for thoracic surgery, University clinical center Nis, Serbia

Keywords: OSA phenotypes, personalized treatment of OSA

Abstract

The combination of sleep fragmentation, intermittent hypoxia exposure and circadian rhythm misalignment is crucial to represent multiple obstructive sleep apnea (OSA) clinical scenarios. Treatment of OSA has traditionally been directed to anatomical component treatment, implying the application of continuous positive airway pressure (CPAP) therapy, oral devices, upper airways surgery, weight loss, and positional therapy. These therapeutic approaches may be frustrating, especially in patients who fail to tolerate CPAP therapy, they may require personal engagement and are hardly maintained, or they have variable and hardly predictable efficacy. So, new treatment approaches aiming at specific, treatable, phenotype characteristics of OSA are needed as alternative therapeutic options.

References

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