THREE-YEAR COMPARATIVE ANALYSIS OF THE PRESENCE OF MENINGIOMAS AND SECONDARY DEPOSITS IN THE BRAIN
Abstract
About 16% of the world’s population is covered by registration systems that provide cancer incidence statistics, while mortality data are available for about 29%. The percentage of metastatic changes in the brain, as secondary deposits, is also increasing. Meningiomas are most often slow-growing, benign, primary intracranial tumors in adults, middle-aged (45 to 55 years). Early detection, favorable localization in the brain and well-performed surgery bring good results to the patient in terms of improved outcome.
A retrospective study included patients with metastatic changes in the brain and meningiomas treated at the Clinic of Neurosurgery and the Clinic of Oncology of the University Clinical Center Niš in the period from the beginning of 2018 to the end of 2020.
By comparing the ratio of the presence of meningioma, as benign tumors in the brain, in relation to the percentage of secondary deposits present, we come to the conclusion that malignancy is on the rise. Early diagnosis and suspicion of this dissemination in primary metastasis enable surgical intervention followed by oncological treatment, which together prolong the patient's life.
Comparing the patients with meningioma who underwent surgery in the period from 2018 to 2020 according to gender, age structure, tumor localization, no statistically significant difference was observed. Females are ahead of males in terms of meningioma.
There has been an evident increase in malignancy in recent years in both genders. In meningioma, the treatment is surgical. In case of solitary changes after surgery, oncological treatment is performed. In the case of multiple changes in the brain, the treatment is oncological, which includes the use of radio and chemotherapy.
References
Al-Shamy G, Sawaya R. Management of brain metastases: the indispensable role of surgery. J Neurooncol 2009;92(3):275-82. [CrossRef] [PubMed]
Amer MH, Al-Sarraf M, Baker LH, Vaitkevicius VK. Malignant melanoma and central nervous system metastases: incidence, diagnosis, treatment and survival. Cancer 1978;42(2):660-8. [CrossRef] [PubMed]
Bassiouni H, Asgari S, Stolke D. Tuberculum sellae meningiomas: functional outcome in a consecutive series treated microsurgically. Surg Neurol 2006; 66(1):37-45. [CrossRef] [PubMed]
Buschmann U, Gers B, Hildebrandt G. Uncommon case of a cystic papillary meningioma in an adoles-cent. Childs Nerv Syst 2005;21(4):322-326. [CrossRef] [PubMed]
Caroli E, Russillo M, Ferrante L. Intracranial meningio-mas in children: report of 27 new cases and critical analysis of 440 cases reported in the literature. J Child Neurol 2006;21(1):31-6. [CrossRef] [PubMed]
Cavenee WK, Weller M, Furnari FB, Berens ME, Nagane M, Plate KH, et al. Diffuse infiltrating astro-cytomas. In: Cavenee WK, Kleihues P, editors. Pathology and Genetics of Tumors of the Nervous System. Lyon: IARC Press;2000.p.9-51.
Eltawansy SA, Panasiti R, Hasanien S, Lourdusamy D, Sharon D. Metastatic malignant melanoma of the inguinal lymph node with unknown primary lesion. Case Rep Med 2015;2015:879460. [CrossRef] [PubMed]
Gavurova B, Toth P. Preventable Mortality in Regions of Slovakia-Quantification of Regional Disparities and Investigation of the Impact of Environmental Factors. Int J Environ Res Public Health 2019;16(8):1382. [CrossRef] [PubMed]
Goto T, Ohata K. Surgical Resectability of Skull Base Meningiomas. Neurol Med Chir (Tokyo) 2016;56(7): 372-8. [CrossRef] [PubMed]
Granger A, Sainsbury R, Wilkinson T, MacFarlane M. Multiple meningiomas: case report and review of the literature. J Clin Neurosci 2000;7(2):149-52. [CrossRef] [PubMed]
Grujičić M, Vučković N, Vuleković P. Osnovne morfološke karakteristike meningeoma. Medicinski pregled 2010;63(3-4):237-40. [CrossRef] [PubMed]
Ius T, Tel A, Minniti G,Somma T, Solari D, Longhi M, et al. Advances in Multidisciplinary Management of Skull Base Meningiomas. Cancers (Basel) 2021; 13(11):2664. [CrossRef] [PubMed]
Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010 [published correction appears in CA Cancer J Clin. 2011 Mar-Apr;61(2):133-4]. CA Cancer J Clin. 2010;60(5):277-300. [CrossRef] [PubMed]
Jideani AIO, Silungwe H, Takalani T, Omolola AO, Udeh HO, Anyasi TA. Antioxidant-rich natural fruit and vegetable products and human health. International Journal of Food Properties 2021;24.1:41-67. [CrossRef]
Kako se plucni rak siri do mozga (online). “cited 2022 March 16”. Available from: https://bs.approby.com/kada-se-plucni-rak-siri-do-mozga
Kuranari Y, Tamura R, Tsuda N, Kosugi K, Morimoto Y, Yoshida K, et al. Long-Term Clinical Outcome of First Recurrence Skull Base Meningiomas. J Clin Med 2019; 9(1):106. [CrossRef] [PubMed]
Kuratsu J, Takeshima H, Ushio Y. Trends in the incidence of primary intracranial tumors in Kumamoto, Japan. Int J Clin Oncol 2001;6(4):183-91. [CrossRef] [PubMed]
Lantos PL, Louis DN, Rosenblum MK, Kleihus P. Tumours of the nervous system. In: Graham DI, Lantos PL, editors. Greenfield’s neuropathology. 7th ed. London: Edward Arnold; 2002;(2):767-980.
Lugasi A, Bíró L, Hóvárie J, Sági KV, Brandt S, Barna É. Lycopene content of foods and lycopene intake in two groups of the Hungarian population. Nutrition Research 2003;23(8):1035-44. [CrossRef] [PubMed]
Maher EA, Mietz J, Arteaga CL, DePinho RA, Mohla S. Brain metastasis: opportunities in basic and trans-lational research. Cancer Res 2009;69(15):6015-20. [CrossRef] [PubMed]
Mattei TA, Mattei JA, Ramina R, Aguiar PH, Plese JP, Marino R Jr. Edema and malignancy in meningiomas. Clinics (Sao Paulo) 2005;60(3):201-6. [CrossRef] [PubMed]
Milenković S, Marinković T, Jovanović MB, Đuričić S, Berisavac II, Berisavac I. Cyclin D1 immunoreactivity in meningiomas. Cell Mol Neurobiol 2008;28(6):907-13. [CrossRef] [PubMed]
Owonikoko TK, Arbiser J, Zelnak A, Shu HG, Shim H, Robina AM, et al. Current approaches to the treatment of metastatic brain tumours. Nat Rev Clin Oncol 2014;11(4):203-22. [CrossRef] [PubMed]
Parkin DM, Fernández LM. Use of statistics to assess the global burden of breast cancer. Breast J 2006;12 Suppl 1:S70-S80. [CrossRef] [PubMed]
Radovich TJK. Biology and Classification of Vegetables. In: Sinha NK, Hui YH, Evranuz EO, Siddiq M, Ahmed J, editors. Handbook of Vegetables and Vegetable Pro-cessing. Iowa: Blackwell Publishing; 2011.p.43-7. [CrossRef]
Rajaratnam A, Waugh J. Adrenal metastases of malignant melanoma: characteristic computed tomo-graphy appearances. Australas Radiol 2005;49(4): 325-9. [CrossRef] [PubMed]
Scoccianti S, Ricardi U. Treatment of brain metastases: review of phase III randomized controlled trials. Radiother Oncol 2012;102(2):168-179. [CrossRef] [PubMed]
Singh S, Amirtham U, Premalata CS, Lakshmaiah KC, Viswanath L, Kumar RV. Spectrum of metastatic neoplasms of the brain: A clinicopathological study in a tertiary care cancer centre. Neurol India 2018; 66(3):733-8. [CrossRef] [PubMed]
Sloan AE, Nock CJ, Einstein DB. Diagnosis and treatment of melanoma brain metastasis: a literature review. Cancer Control 2009;16(3):248-55. [CrossRef] [PubMed]
Soffietti R, Rudā R, Mutani R. Management of brain metastases. J Neurol 2002;249(10):1357-69. [CrossRef] [PubMed]
Suhani KM, Ali S, Aggarwal L, Thomas S. Malignant melanoma presenting as inguinal nodal metastasis with unknown primary: a rare presentation. The Inter-net Journal of Surgery 2013;30(2):1541.
Tufan K, Dogulu F, Kurt G, Emmez H, Ceviker N, Baykaner MK. Intracranial meningiomas of childhood and adolescence. Pediatr Neurosurg 2005;41(1):1-7. [CrossRef] [PubMed]
Weir HK, Thun MJ, Hankey BF, Ries LAG, Howe HL, Wingo PA, et al. Annual report to the nation on the status of cancer, 1975-2000, featuring the uses of surveillance data for cancer prevention and control [published correction appears in J Natl Cancer Inst 2003 Nov 5;95(21):1641]. J Natl Cancer Inst 2003; 95(17):1276-99. [CrossRef] [PubMed]