ATOPIC DERMATITIS IN CHILDREN
Abstract
Atopic dermatitis represents a non-infectious, multifactorial inflammatory and chronic dermatosis. Pruritus is the main symptom. The pathophysiology of atopic dermatitis is very complex and includes genetic disorders, a defect in the epidermal barrier, an altered immune response and a disruption of the skin's microbial balance, all of which damage the epidermis, causing itchy skin lesions. The prevalence varies, but it is generally present in 30% of children, and 85% of cases manifest before the age of 5. The triad of atopic diseases consists of atopic dermatitis, allergic rhinitis and asthma. A retrospective analysis of the documentation of the children who were treated at the Pediatric Clinic of the University Clinical Center Niš from 2018 to 2019 focused on anamnestic data, clinical manifestations, and laboratory parameters obtained from the medical records of the subjects. The total number of examined children was 40, among them, 21 were male and 19 female. They were divided into 3 age groups, from 2 months to 7 years. Anamnestic data indicate a connection between AD and other disorders of atopic diseases, allergic rhinitis, asthma, respiratory infections, and milk allergies.
References
Alberto Arnedo-Pena, Luis García-Marcos, Uruena IC, Monge RB, Suarez-Varela MM, Canflanca IM, et al,Air pollution and recent symptoms of asthma, allergic rhinitis, and atopic eczema in schoolchildren aged between 6 and 7 years. Arch Bronconeumol 2009; 45(5): 224-9. [CrossRef] [PubMed]
BaurechtH, Ruhlemann MC, Rodriguez E, Thielking F, Harden I, Erkens AS, et al. Epidermal lipid composition, barrier integrity, and eczematous inflammation are associated with skin microbiome configuration. J Allergy Clin Immunol 2018; 141(5): 1668–76. [CrossRef] [PubMed]
Chu C-Y, Lee C-H, Shih IH, Chen HC, Huang PH, Yang CY, et al. Taiwanese Dermatological Association consensus for the management of atopic dermatitis. Dermatol Sin 2015; 33(4): 220‐30. [CrossRef]
Galli E, Neri I, Ricci G, Baldo E, Barone M, Fortina AB, et al. Consensus conference on clinical management of pediatric atopic dermatitis. Ital J Pediatr 2016; 42: 26. [CrossRef] [PubMed]
Hon KL, Wang SS, and Leung TF. The atopic march: From skin to the airways. Iran J Allergy Asthma Immunol 2012; 11: 73–7. [PubMed]
Jonathan M Spergel, Atopic march: link to upper airways, CurrOpin Allergy Clin Immunol 2005; 5(1): 17-21. [CrossRef] [PubMed]
Kennedy EA, Connolly J, Hourihane JO, Fallon PG, McLean IWH, Murray D, et al. Skin microbiome before development of atopic dermatitis: Early colonization with commensal staphylococci at 2 months is associated with a lower risk of atopic dermatitis at 1 year. J Allergy Clin Immunol 2017; 139(1): 166 – 72. [CrossRef] [PubMed]
Kijima A, Murota H, Takahashi A, Arase N, Yang L, Nishioka M, et al. Prevalence and impact of past history of food allergy in atopic dermatitis. Allergol Int 2013; 62: 105–12. [CrossRef] [PubMed]
LePoidevin LM, Lee DE, Shi VY. A comparison of international management guidelines for atopic dermatitis. Pediatr Dermatol 2019; 36: 36–65. [CrossRef] [PubMed]
Martín Ramírez-Soto, Martín Bedolla-Barajas, Tania González-Mendoza, Prevalence of asthma, allergic rhinitis and atopic dermatitis in school children of the Mexican Bajío region , Rev Alerg Mex 2018; 65(4): 372-8. [CrossRef] [PubMed]
Meng J, Moriyama M, Feld M, Buddenkotte J, Buhl T, Szollosi A, et al. New mechanism underlying IL-31-induced atopic dermatitis. J Allergy Clin Immunol 2018; 141(5): 1677–89. [CrossRef] [PubMed]
National Collaborating Centre for Women's and Children's Health (UK). National Institute for Health and Clinical Excellence: Guidance. Atopic eczema in children: management of atopic eczema in children from birth up to the age of 12 years. London: RCOG Press; 2007. [PubMed]
Roesner LM, Heratizadeh A, Wieschowski S, Mittermann I, Valenta R, Vesper BE, et al. α -NAC-specific autoreactive CD8 + T cells in atopic dermatitis are of an effector memory type and secrete IL-4 and IFN- γ. J Immunol 2016; 196(8): 3245 – 52. [CrossRef] [PubMed]
Sathishkumar D, Moss C. Topical therapy in atopic dermatitisin children. Indian J Dermatol. 2016; 61(6): 656-61. [CrossRef] [PubMed]
Silverberg JI, Nelson DB, Yosipovitch G. Addressing treatment challenges in atopic dermatitis with novel topical therapies. J Dermatolog Treat 2016; 27(6): 568-76. [CrossRef] [PubMed]
Wassmann-Otto A, Heratizadeh A, Wichmann K, Werfel T. Birch pollen-related foods can cause late eczematous reactions in patients with atopic dermatitis. Allergy 2018; 73(10): 2046 – 54. [CrossRef] [PubMed]
Williams HC. Established corticosteroid creams should be applied only once daily in patients with atopic eczema. BMJ 2007; 334. [CrossRef] [PubMed]