Retinol Binding Protein 4 Levels relate to the presence and severity of coronary artery disease

RBP-4 and coronary artery disease

  • Gokay Nar Pamukkale University
  • Sara Cetin Sanlialp Servergazi State Hospital
  • rukiye nar Pamukkale University
Keywords: Adipokine, acute coronary syndrome, retinol binding protein 4, CAD severity


Background: The prevous studies has showed that serum retinol binding protein 4 (RBP4) levels increased in metobolic disorders which are closely associated with cardiovascular dieases (CVD).  However the human studies investigating the role of RBP4 in CVD are conflicted. Therefore, we aimed to evaluate the relationship between RBP4 and the presence and the severity of coronary artery disease (CAD) in this study.

Methods: 55 patients with presenting acute coronary syndrome (ACS) and 43 control subjects who had various cardiovascular risk factors with normal coronary artery on coronary angiography were included in this study.The serum RBP4 concentrations were measured using ELISA method and clinically and anatomically score models were used to asses the severity of coronary lesion.

Results: Serum RBP4 level was significantly higher in patients with ACS compared to the controls (68.40 ± 47.94 mg/L vs. 49.46 ± 13.64 mg/L; p = 0.014).  RBP4 was correlated with GENSINI and SYNTAX I score (r = 0,286 p=0,034; r = 0.403 p = 0.002 respectively). However, there was no relationship between RBP4 and GRACE score.

Conclusion: Patients with ACS had increased serum RBP4 levels and its high levels were correlated with CAD severity.

Author Biographies

Gokay Nar, Pamukkale University

Faculty of Medicine, Department of Cardiology, Denizli

Sara Cetin Sanlialp, Servergazi State Hospital

Department of Cardiology, Denizli


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Original paper