Retinol Binding Protein 4 Levels relate to the presence and severity of coronary artery disease
RBP-4 and coronary artery disease
Background: The prevous studies has showed that serum retinol binding protein 4 (RBP4) levels increased in metobolic disorders which are closely associated with cardiovascular dieases (CVD). However the human studies investigating the role of RBP4 in CVD are conflicted. Therefore, we aimed to evaluate the relationship between RBP4 and the presence and the severity of coronary artery disease (CAD) in this study.
Methods: 55 patients with presenting acute coronary syndrome (ACS) and 43 control subjects who had various cardiovascular risk factors with normal coronary artery on coronary angiography were included in this study.The serum RBP4 concentrations were measured using ELISA method and clinically and anatomically score models were used to asses the severity of coronary lesion.
Results: Serum RBP4 level was significantly higher in patients with ACS compared to the controls (68.40 ± 47.94 mg/L vs. 49.46 ± 13.64 mg/L; p = 0.014). RBP4 was correlated with GENSINI and SYNTAX I score (r = 0,286 p=0,034; r = 0.403 p = 0.002 respectively). However, there was no relationship between RBP4 and GRACE score.
Conclusion: Patients with ACS had increased serum RBP4 levels and its high levels were correlated with CAD severity.
2. Liu T, Han C, Sun L, Ding Z, Shi F, Wang R, et al. Association between new circulating proinflammatory and antiinflammatory adipocytokines with coronary artery disease. Coronary Artery Disease 2019, 30:528–535. https://pubmed.ncbi.nlm.nih.gov/31464731/
3. Friebe D, Neef M, Erbs S, Dittrich K, Kratzsch J, Kovacs P, et al. Retinol binding protein 4 (RBP4) is primarily associated with adipose tissue mass in children. Int J Pediatr Obes 2011;6: 345–352. https://pubmed.ncbi.nlm.nih.gov/20950077/
4. Kotnik P, Fischer-Posovszky P, Wabitsch M. RPB4: a controversial adipokine. Eur J Endocrinol 2011; 165: 703–711. https://pubmed.ncbi.nlm.nih.gov/21835764/
5. Craig RL, Chu WS, Elbein SC. Retinol binding protein 4 as a candidate gene for type 2 diabetes and prediabetic intermediate trails. Mole Genet Metab 2007; 90: 338–344. https://pubmed.ncbi.nlm.nih.gov/17174134/
6. Sun Q, Kiernan UA, Shi L, Phillips DA, Kahn BB, Hu FB, et al. Plasma retinol-binding protein 4 (RBP4) levels and risk of coronary heart disease: a prospective analysis among women in the nurses’ health study. Circulation 2013; 127: 1938-1947. https://pubmed.ncbi.nlm.nih.gov/23584360/
7. Liu Y, Wang D, Chen H, Xia M. Circulating retinol binding protein 4 is associated with coronary lesion severity of patients with coronary artery disease. Atherosclerosis 2015; 238:45–51. https://pubmed.ncbi.nlm.nih.gov/25437889/
8. Dessein PH, Tsang L, Norton GR, Woodiwiss AJ, Solomon A. Retinol Binding Protein 4 Concentrations Relate to Enhanced Atherosclerosis in Obese Patients with Rheumatoid Arthritis. PLoS ONE 2014; 9(3): e92739. https://doi.org/10.1371/journal.pone.0092739.
9. Fox KA, Dabbous OH, Goldberg RJ, Pieper KS, Eagle KA, Van de Werf F, et al. Prediction of risk of death and myocardial infarction in the six months after presentation with acute coronary syndrome: prospective multinational observational study (GRACE). BMJ 2006; 333: 1091. https://pubmed.ncbi.nlm.nih.gov/17032691/
10. Gensini GG. Coronary arteriography: role in myocardial revascularization. Postgrad Med 1978;63(1):121- 8. https://pubmed.ncbi.nlm.nih.gov/637926/
11. SYNTAX working group. SYNTAX score calculator. Available at http://www.syntaxscore.com. Accessed May 20, 2012.
12. Endemann DH, Schiffrin EL. Endothelial dysfunction. J Am Soc Nephrol 2004;15:1983– 1992. https://pubmed.ncbi.nlm.nih.gov/15284284/
13. Farjo KM, Farjo RA, Halsey S, Moiseyev G, Ma JX.. Retinol-binding protein 4 induces inflammation in human endothelial cells by an NADPH oxidase- and nuclear factor kappa B-dependent and retinol-independent mechanism. Cole Cell Biol 2012; 32: 5103–5115. https://pubmed.ncbi.nlm.nih.gov/23071093/
14. Zabetian-Targhi F, Mahmoudi MJ, Rezaei N, Mahmoudi M. Retinol Binding Protein 4 in Relation to Diet, Inflammation, Immunity, and Cardiovascular Diseases. Adv Nutr 2015;6:748–762. https://pubmed.ncbi.nlm.nih.gov/26567199/
15. Alkharfy KM, Al-Daghri NM, Vanhoutte PM, Krishnaswamy S, Xu A. Serum Retinol-Binding Protein 4 as a Marker for Cardiovascular Disease in Women. PLoS ONE 2012;7(10):e48612. https://pubmed.ncbi.nlm.nih.gov/23119072/
16. Lambadiari V, Kadoglou NPE, Stasinos V, Maratou E, Antoniadis A, Kolokathis F, et al. Serum levels of retinol-binding protein-4 are associated with the presence and severity of coronary artery disease. Cardiovasc Diabetol . 2014 Aug 21;13:121. https://pubmed.ncbi.nlm.nih.gov/25142320/
17. Hammamia R, Jdidi J, Mroua F, Kallel R, Hentati M, Abid L, et al. Accuracy of the TIMI and GRACE scores in predicting coronary disease in patients with non-ST-elevation acute coronary syndrome. Revista Portuguesa de Cardiologia (English Edition) 2018; 37(1):41-49. https://pubmed.ncbi.nlm.nih.gov/29361323/
18. Kim JH, Rhee EJ, Choi ES, Won JC, Park CY, Lee WY, et al. The Relationship between Serum Retinol-Binding Protein 4 Levels and Coronary Artery Disease in Korean Adults. Korean Diabetes J 2009;33:105-112.
19. von Eynatten M, Lepper PM, Liu D, Lang K, Baumann M, Nawroth PP, et al. Retinol-binding protein 4 is associated with components of the metabolic syndrome, but not with insulin resistance, in men with type 2 diabetes or coronary artery disease. Diabetologia. 2007;50:1930–1937. https://pubmed.ncbi.nlm.nih.gov/17639305/
20. Ingelsson E, Sundstrom J, Melhus H, Michaëlsson K, Berne C, Vasan RS, et al. Circulating retinol-binding protein 4, cardiovascular risk factors and prevalent cardiovascular disease in elderly. Atherosclerosis. 2009;206:239–244. https://pubmed.ncbi.nlm.nih.gov/19339013/
21. Von Eynatten M, Humpert PM. Retinol-binding protein-4 in experimental and clinical metabolic disease. Expert Rev Mol Diagn. 2008;8:289–299. https://pubmed.ncbi.nlm.nih.gov/18598108/
22. Graham TE, Yang Q, Bluher M, Aryal P, Ter Horst KW, Cakir H, et al. Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects. N Engl J Med. 2006;354:2552–2563. https://pubmed.ncbi.nlm.nih.gov/16775236/
23. Balagopal P, Graham TE, Kahn BB, Altomare A, Funanage V, George D. Reduction of elevated serum retinol binding protein in obese children by lifestyle intervention: association with subclinical inflammation. J Clin Endocrinol Metab 2007;92:1971–1974. https://pubmed.ncbi.nlm.nih.gov/17341558/
24. Aigner E, Bachofner N, Klein K, De Geyter C, Hohla F, Patsch W, et al. Retinol-binding protein 4 in polycystic ovary syndrome—association with steroid hormones and response to pioglitazone treatment. J Clin Endocrinol Metab 2009;94:1229–1235. https://pubmed.ncbi.nlm.nih.gov/19158194/
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