. 25-HYDROXYVITAMIN D (25-OHD) LEVELS in TURKISH GERIATRIC POPULATION: A NATIONWIDE STUDY
25-OHD LEVELS in TURKISH GERIATRIC POPULATION
Abstract
Background: 25-hydroxyvitamin D (25-OHD) deficiency is a major health problem worldwide and is associated with many chronic diseases in geriatric population. There is not any 25-OHD levels data among individuals overage 65 so far in Turkey. The aim of this study is to assess 25-OHD levels and the seasonal variations in people over the age of 65 living in Turkey.
Methods: Working across Turkey, 2016, and 2017, the number of tests studied vitamin D in the population over the age of 65 in 2018 were included. Age, gender and seasonal average values were defined. The study data were obtained from the database of the Ministry of Health. Kolmogorov-Smirnov test was used for the distribution of the data. Median and interquartile range (IQR) were calculated for all categories, as the data were non-parametric.
Results: The number of tests belonging to geriatric individuals included in the study was 305,329 tests for 2016, 576,452 tests for 2017 and 752,837 tests for 2018. The median and the IQR of the 25-OHD in elderly population were 16 ng/mL (IQR 7.45-24.55 ng/mL), 16.1 ng/mL (IQR 7.8-24.4 ng/mL), 16.4 ng/mL (IQR 8.95-23.85 ng/mL) respectively.
Conclusions: In Turkey during the period of seasonal sunlight, although it is in 25-OHD levels in older men tend to increase this variability was observed in elderly women. This suggests that older women tend to live more sedentary and do not get enough of the sunrays. The median 25-OHD levels of individuals over the age of 65 tend to decrease each year.
References
2. Holick, M.F., High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc, 2006. 81(3): p. 353-73.
3. van der Wielen, R.P., M.R. Löwik, H. van den Berg, L.C. de Groot, J. Haller, O. Moreiras, et al., Serum vitamin D concentrations among elderly people in Europe. Lancet, 1995. 346(8969): p. 207-10.
4. Holick, M.F., Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr, 2004. 80(6 Suppl): p. 1678s-88s.
5. Hedley, A.A., C.L. Ogden, C.L. Johnson, M.D. Carroll, L.R. Curtin, and K.M. Flegal, Prevalence of overweight and obesity among US children, adolescents, and adults, 1999-2002. Jama, 2004. 291(23): p. 2847-50.
6. Holick, M.F., Resurrection of vitamin D deficiency and rickets. J Clin Invest, 2006. 116(8): p. 2062-72.
7. Bischoff-Ferrari, H.A., M. Borchers, F. Gudat, U. Dürmüller, H.B. Stähelin, and W. Dick, Vitamin D receptor expression in human muscle tissue decreases with age. J Bone Miner Res, 2004. 19(2): p. 265-9.
8. Lin, J., J.E. Manson, I.M. Lee, N.R. Cook, J.E. Buring, and S.M. Zhang, Intakes of calcium and vitamin D and breast cancer risk in women. Arch Intern Med, 2007. 167(10): p. 1050-9.
9. van Schoor, N. and P. Lips, Global Overview of Vitamin D Status. Endocrinol Metab Clin North Am, 2017. 46(4): p. 845-870.
10. Akhtar, S., Vitamin D Status in South Asian Populations - Risks and Opportunities. Crit Rev Food Sci Nutr, 2016. 56(11): p. 1925-40.
11. Prentice, A., Vitamin D deficiency: a global perspective. Nutr Rev, 2008. 66(10 Suppl 2): p. S153-64.
12. MGM. Available from: https//mgm.gov.tr/kurumici/turkiye-guneslenme-suresi.aspx.
13. Hashemipour, S., B. Larijani, H. Adibi, E. Javadi, M. Sedaghat, M. Pajouhi, et al., Vitamin D deficiency and causative factors in the population of Tehran. BMC Public Health, 2004. 4: p. 38.
14. Riaz, H., A.E. Finlayson, S. Bashir, S. Hussain, S. Mahmood, F. Malik, et al., Prevalence of Vitamin D deficiency in Pakistan and implications for the future. Expert Rev Clin Pharmacol, 2016. 9(2): p. 329-38.
15. Trilok Kumar, G., R. Chugh, and M. Eggersdorfer, Poor Vitamin D Status in Healthy Populations in India: A Review of Current Evidence. Int J Vitam Nutr Res, 2015. 85(3-4): p. 185-201.
16. Fanari, Z., S. Hammami, M.B. Hammami, S. Hammami, and A. Abdellatif, Vitamin D deficiency plays an important role in cardiac disease and affects patient outcome: Still a myth or a fact that needs exploration? J Saudi Heart Assoc, 2015. 27(4): p. 264-71.
17. Lips, P., Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev, 2001. 22(4): p. 477-501.
18. Xu, C., R.A. Perera, Y.H. Chan, V.J. Fang, S. Ng, D.K. Ip, et al., Determinants of serum 25-hydroxyvitamin D in Hong Kong. Br J Nutr, 2015. 114(1): p. 144-51.
19. Schleicher, R.L., M.R. Sternberg, A.C. Looker, E.A. Yetley, D.A. Lacher, C.T. Sempos, et al., National Estimates of Serum Total 25-Hydroxyvitamin D and Metabolite Concentrations Measured by Liquid Chromatography-Tandem Mass Spectrometry in the US Population during 2007-2010. J Nutr, 2016. 146(5): p. 1051-61.
20. Nessvi, S., L. Johansson, J. Jopson, A. Stewart, A. Reeder, R. McKenzie, et al., Association of 25-hydroxyvitamin D3)levels in adult New Zealanders with ethnicity, skin color and self-reported skin sensitivity to sun exposure. Photochem Photobiol, 2011. 87(5): p. 1173-8.
21. Nichols, E.K., I.M. Khatib, N.J. Aburto, K.M. Sullivan, K.S. Scanlon, J.P. Wirth, et al., Vitamin D status and determinants of deficiency among non-pregnant Jordanian women of reproductive age. Eur J Clin Nutr, 2012. 66(6): p. 751-6.
22. Ginde, A.A., A.F. Sullivan, J.M. Mansbach, and C.A. Camargo, Jr., Vitamin D insufficiency in pregnant and nonpregnant women of childbearing age in the United States. Am J Obstet Gynecol, 2010. 202(5): p. 436.e1-8.
23. Orwoll, E., C.M. Nielson, L.M. Marshall, L. Lambert, K.F. Holton, A.R. Hoffman, et al., Vitamin D deficiency in older men. J Clin Endocrinol Metab, 2009. 94(4): p. 1214-22.
24. Melhus, H., G. Snellman, R. Gedeborg, L. Byberg, L. Berglund, H. Mallmin, et al., Plasma 25-hydroxyvitamin D levels and fracture risk in a community-based cohort of elderly men in Sweden. J Clin Endocrinol Metab, 2010. 95(6): p. 2637-45.
25. Costanzo, P.R., N.O. Elías, J. Kleiman Rubinsztein, N.X. García Basavilbaso, R. Piacentini, and H.H. Salerni, [Ultraviolet radiation impact on seasonal variations of serum 25-hydroxy-vitamin D in healthy young adults in Buenos Aires]. Medicina (B Aires), 2011. 71(4): p. 336-42.
26. Heidari, B. and M.B. Haji Mirghassemi, Seasonal variations in serum vitamin D according to age and sex. Caspian J Intern Med, 2012. 3(4): p. 535-40.
27. Gonel, A. and A. Yetisgin, False Negative D Vitamin Measurement in LC-MS/MS Method Due to Hyperlipidemia: Case Report. Comb Chem High Throughput Screen, 2019. 22(6): p. 428-430.
28. Gonel, A., I. Kirhan, I. Koyuncu, N. Bayraktar, M.E. Karadag, and M. Karadag, The Role of Interferences in the Increasing Incidence of Vitamin D Deficiency. Endocr Metab Immune Disord Drug Targets, 2020. 20(8): p. 1303-1308.
29. Holick, M.F., Vitamin D deficiency. N Engl J Med, 2007. 357(3): p. 266-81.
30. Mosekilde, L., Vitamin D and the elderly. Clin Endocrinol (Oxf), 2005. 62(3): p. 265-81.
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