Associations of Serum High-Sensitivity C-Reactive Protein and Prealbumin with Coronary Vessels Stenosis determined by Coronary angiography and Heart Failure in Patients with Myocardial Infarction
hs-CRP and prealbumin PAB in myocardial infarction
Abstract
Background: To explore the associations of serum high-sensitivity C-reactive protein (hs-CRP) and prealbumin (PAB) with the number of diseased coronary vessels, degree of stenosis and heart failure in patients with myocardial infarction (MI).
Methods: A total of 39 MI patients treated in the Cardiology were selected as the observation group, and another 41 patients with normal results of coronary angiography during the same period were selected as the control group. The general data of patients were recorded in detail, the content of serum hs-CRP and PAB in the peripheral blood was detected, and the number of diseased coronary vessels and the degree of stenosis were detected via coronary angiography.
Results: Compared with those in control group, the blood pressure and heart rate significantly rose, the content of indexes related to the severity of MI were significantly increased, the content of hs-CRP was significantly increased, and the content of PAB was significantly decreased in observation group. Hs-CRP was positively correlated with the number of diseased coronary vessels, degree of stenosis and heart failure in patients, but PAB was negatively correlated with the above factors. The survival rate of MI patients with high content of hs-CRP was obviously lower than that of patients with low content of hs-CRP.
Conclusion: Serum hs-CRP and PAB are closely associated with the number of diseased coronary vessels, degree of stenosis and heart failure in MI patients.
References
2. Khowaja S, Karim M, Zahid M, Zahid A, Ahmed S, Kazmi K, et al. Impact of Temperature Variation on Acute Myocardial Infarction in Karachi, Pakistan. Cureus 2019; 11(10): e5910.
3. Ortega-Rodriguez AC, Marin-Jauregui LS, Martinez-Shio E, Hernandez CB, Gonzalez-Amaro R, Escobedo-Uribe CD, et al. Altered NK cell receptor repertoire and function of natural killer cells in patients with acute myocardial infarction: A three-month follow-up study. Immunobiology 2020; 225(3): 151909.
4. Ridker PM, MacFadyen JG, Glynn RJ, Bradwin G, Hasan AA, Rifai N. Comparison of interleukin-6, C-reactive protein, and low-density lipoprotein cholesterol as biomarkers of residual risk in contemporary practice: secondary analyses from the Cardiovascular Inflammation Reduction Trial. Eur Heart J 2020; 41(31): 2952-61.
5. Nikorowitsch J, Ojeda F, Lackner KJ, Schnabel RB, Blankenberg S, Zeller T, et al. Head-to-Head Comparison of the Incremental Predictive Value of The Three Established Risk Markers, Hs-troponin I, C-Reactive Protein, and NT-proBNP, in Coronary Artery Disease. Biomolecules 2020; 10(3): 394.
6. Dag Z, Koseoglu H, Kekilli M. The use of prealbumin as a predictor of malnutrition in cirrhotic patients and the effect of nutritional support in patients with low prealbumin levels. Turk J Med Sci 2020; 50(2): 398-404.
7. Sun DW, An L, Lv GY. Albumin-fibrinogen ratio and fibrinogen-prealbumin ratio as promising prognostic markers for cancers: an updated meta-analysis. World J Surg Oncol 2020; 18(1): 9.
8. Sun Z, Pang S, Cui Y, Yan B. Genetic and Functional Variants Analysis of the GATA6 Gene Promoter in Acute Myocardial Infarction. Front Genet 2019; 10: 1100.
9. Nikorowitsch J, Borchardt T, Appelbaum S, Ojeda F, Lackner KJ, Schnabel RB, et al. Cardio-Renal Biomarker Soluble Urokinase-Type Plasminogen Activator Receptor Is Associated With Cardiovascular Death and Myocardial Infarction in Patients With Coronary Artery Disease Independent of Troponin, C-Reactive Protein, and Renal Function. J Am Heart Assoc 2020; 9(8): e15452.
10. Cosentino N, Genovese S, Campodonico J, Bonomi A, Lucci C, Milazzo V, et al. High-Sensitivity C-Reactive Protein and Acute Kidney Injury in Patients with Acute Myocardial Infarction: A Prospective Observational Study. J Clin Med 2019; 8(12): 2192.
11. Ljuca F, Hadziefendic B, Jahic E, Tihic N, Lukic S. Pentraxin 3 might be better prognostic serum marker than IL-6, IL-10, and high-sensitivity C-reactive protein for major adverse cardiovascular events in patients with ST-elevation myocardial infarction after bare-metal stent implantation. Saudi Med J 2019; 40(12): 1202-8.
12. Foroughinia F, Tabibi AA, Javanmardi H, Safari A, Borhani-Haghighi A. Association between high sensitivity C-reactive protein (hs-CRP) levels and the risk of major adverse cardiovascular events (MACE) and/or microembolic signals after carotid angioplasty and stenting. Caspian J Intern Med 2019; 10(4): 388-95.
13. Hong Y, Seese L, Hickey G, Mathier M, Thoma F, Kilic A. Preoperative prealbumin does not impact outcomes after left ventricular assist device implantation. J Card Surg 2020; 35(5): 1029-36.
14. Matsunaga T, Miyata H, Sugimura K, Motoori M, Asukai K, Yanagimoto Y, et al. Prognostic Significance of C-reactive Protein-to-prealbumin Ratio in Patients with Esophageal Cancer. Yonago Acta Med 2020; 63(1): 8-19.
15. Fu EL, Franko MA, Obergfell A, Dekker FW, Gabrielsen A, Jernberg T, et al. High-sensitivity C-reactive protein and the risk of chronic kidney disease progression or acute kidney injury in post-myocardial infarction patients. Am Heart J 2019; 216: 20-9.
16. Kalyoncuoglu M, Durmus G. Relationship between C-reactive protein-to-albumin ratio and the extent of coronary artery disease in patients with non-ST-elevated myocardial infarction. Coron Artery Dis 2020; 31(2): 130-6.
17. Al AZ, Habib SS, Marzouk A. Predictive value of high sensitivity C-reactive protein on progression to heart failure occurring after the first myocardial infarction. Vasc Health Risk Manag 2019; 15: 221-7.
18. Liu Y, Jia SD, Yao Y, Tang XF, Xu N, Jiang L, et al. Impact of high-sensitivity C-reactive protein on coronary artery disease severity and outcomes in patients undergoing percutaneous coronary intervention. J Cardiol 2020; 75(1): 60-5.
19. Shimizu T, Suwa S, Dohi T, Wada H, Miyauchi K, Shitara J, et al. Clinical Significance of High-Sensitivity C-Reactive Protein in Patients with Preserved Renal Function Following Percutaneous Coronary Intervention. Int Heart J 2019; 60(5): 1037-42.
20. Wang J, Xi H, Zhang K, Li Z, Li L, Chen J, et al. Circulating C-Reactive Protein to Prealbumin Ratio and Prealbumin to Fibrinogen Ratio are Two Promising Inflammatory Markers Associated with Disease Activity in Rheumatoid Arthritis. Clin Lab 2020; 66(5):
21. Wang W, Wang CS, Ren D, Li T, Yao HC, Ma SJ. Low serum prealbumin levels on admission can independently predict in-hospital adverse cardiac events in patients with acute coronary syndrome. Medicine (Baltimore) 2018; 97(30): e11740.
Copyright (c) 2022 Yun Zhu, Zhen Yu, Ronggui Xu, Beibei Wang, Yiqun Lou, Na Zhang, Ziyin Chen
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