Association between triglyceride-glucose index and acute kidney injury in patients with acute myocardial infarction based on Medical Information Mart for Intensive Care database: A cross-sectional study
Triglyceride-Glucose Index and Acute Kidney Injury in Myocardial Infarction
Abstract
Background: The relationship between triglyceride glucose (TyG) index and the incidence of acute kidney injury (AKI) in patients with acute myocardial infarction (AMI) is unclear. This study aims to explore the relationship between the two.
Methods: Participants were enrolled from Medical Information Mart for Intensive Care IV (MIMICIV) and grouping of subjects based on the quartile interval of the TyG index. With the presence of AKI as the main outcome, a logistic regression model was constructed. The correlation of the TyG index with the results obtained was examined by using a restricted cubic spline (RCS) model.
Results: Among the 1,101 AMI participants, 64.7% were male patients and the overall incidence rate of AKI was 37.1%. The results of multivariate Logistic regression analysis (LRA) revealed independent correlation of the TyG index with increased AKI risk (odds ratio (OR) = 2.23; confidence interval (CI) = 1.59 to 3.17; P < 0.001). Q4 (9.5-12.208) in the TyG index quartile was independently correlated with increased AKI risk (OR = 2.99, 95% CI = 1.64 to 5.46, P < 0.001). The RCS model showed that the AKI risk increased linearly as the TyG index increased (P=0.313).
Conclusion: In patients with AMI, the incidence of TyG and AKI is closely related. Nevertheless, further studies are needed to verify the finding.
References
1. Chalikias G, Serif L, Kikas P, Thomaidis A, Stakos D, Makrygiannis D, et al. Long-term impact of acute kidney injury on prognosis in patients with acute myocardial infarction. Int J Cardiol 2019; 283: 48-54.
2. Parikh CR, Coca SG, Wang Y, Masoudi FA, Krumholz HM. Long-term prognosis of acute kidney injury after acute myocardial infarction. Arch Intern Med 2008; 168(9): 987-95.
3. Queiroz RE, de Oliveira LS, de Albuquerque CA, Santana CA, Brasil PM, Carneiro LL, et al. Acute kidney injury risk in patients with ST-segment elevation myocardial infarction at presentation to the ED. Am J Emerg Med 2012; 30(9): 1921-7.
4. Chertow GM, Burdick E, Honour M, Bonventre JV, Bates DW. Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J Am Soc Nephrol 2005; 16(11): 3365-70.
5. Rodrigues FB, Bruetto RG, Torres US, Otaviano AP, Zanetta DM, Burdmann EA. Incidence and mortality of acute kidney injury after myocardial infarction: a comparison between KDIGO and RIFLE criteria. Plos One 2013; 8(7): e69998.
6. Micarelli D, Cristi E, Taddei AR, Rovere F, Mercanti C, Feriozzi S. A case of acute renal failure with multiple origins of the renal injury. Cen Case Rep 2020; 9(4): 437-41.
7. Lei L, Li LP, Zeng Z, Mu JX, Yang X, Zhou C, et al. Value of urinary KIM-1 and NGAL combined with serum Cys C for predicting acute kidney injury secondary to decompensated cirrhosis. Sci Rep-Uk 2018; 8(1): 7962.
8. Qin Y, Tang H, Yan G, Wang D, Qiao Y, Luo E, et al. A High Triglyceride-Glucose Index Is Associated With Contrast-Induced Acute Kidney Injury in Chinese Patients With Type 2 Diabetes Mellitus. Front Endocrinol 2020; 11: 522883.
9. Giesa N, Heeren P, Klopfenstein S, Flint A, Agha-Mir-Salim L, Poncette A, et al. MIMIC-IV as a Clinical Data Schema. Stud Health Technol Inform 2022; 294: 559-60.
10. Kellum JA, Lameire N. Diagnosis, evaluation, and management of acute kidney injury: a KDIGO summary (Part 1). Crit Care 2013; 17(1): 204.
11. Yang Q, Zheng J, Chen W, Chen X, Wen D, Chen W, et al. Association Between Preadmission Metformin Use and Outcomes in Intensive Care Unit Patients With Sepsis and Type 2 Diabetes: A Cohort Study. Front Med-Lausanne 2021; 8(640785.
12. Waikar SS, Bonventre JV. Creatinine kinetics and the definition of acute kidney injury. J Am Soc Nephrol 2009; 20(3): 672-9.
13. Forni LG, Darmon M, Ostermann M, Oudemans-van SH, Pettila V, Prowle JR, et al. Renal recovery after acute kidney injury. Intens Care Med 2017; 43(6): 855-66.
14. Zhao S, Yu S, Chi C, Fan X, Tang J, Ji H, et al. Association between macro- and microvascular damage and the triglyceride glucose index in community-dwelling elderly individuals: the Northern Shanghai Study. Cardiovasc Diabetol 2019; 18(1): 95.
15. Shi W, Liu S, Jing L, Tian Y, Xing L. Estimate of reduced glomerular filtration rate by triglyceride-glucose index: insights from a general Chinese population. Postgrad Med 2019; 131(4): 287-94.
16. Liu N, Liu C, Qu Z, Tan J. Association between the triglyceride-glucose index and chronic kidney disease in adults. Int Urol Nephrol 2023; 55(5): 1279-89.
17. Oh D, Park SH, Lee S, Yang E, Choi HY, Park HC, et al. High Triglyceride-Glucose Index with Renal Hyperfiltration and Albuminuria in Young Adults: The Korea National Health and Nutrition Examination Survey (KNHANES V, VI, and VIII). J Clin Med 2022; 11(21):
18. Lei L, Liang H, Qu Y, Zhong Q, Zhang Q, Dai L, et al. Association between triglyceride-glucose index and worsening renal function in the elderly. Front Nutr 2022; 9: 951564.
19. Shacham Y, Gal-Oz A, Leshem-Rubinow E, Arbel Y, Keren G, Roth A, et al. Admission Glucose Levels and the Risk of Acute Kidney Injury in Nondiabetic ST Segment Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention. Cardiorenal Med 2015; 5(3): 191-8.
20. Ruparelia N, Digby JE, Jefferson A, Medway DJ, Neubauer S, Lygate CA, et al. Myocardial infarction causes inflammation and leukocyte recruitment at remote sites in the myocardium and in the renal glomerulus. Inflamm Res 2013; 62(5): 515-25.
21. Wang J, Liu B, Han H, Yuan Q, Xue M, Xu F, et al. Acute Hepatic Insulin Resistance Contributes to Hyperglycemia in Rats Following Myocardial Infarction. Mol Med 2015; 21(1): 68-76.
22. Qin YH, Yan GL, Ma CL, Tang CC, Ma GS. Effects of hyperglycaemia and elevated glycosylated haemoglobin on contrast-induced nephropathy after coronary angiography. Exp Ther Med 2018; 16(1): 377-83.
23. Hunley TE, Ma LJ, Kon V. Scope and mechanisms of obesity-related renal disease. Curr Opin Nephrol Hy 2010; 19(3): 227-34.
24. Johnson AC, Stahl A, Zager RA. Triglyceride accumulation in injured renal tubular cells: alterations in both synthetic and catabolic pathways. Kidney Int 2005; 67(6): 2196-209.
25. Zager RA. Plasma membrane cholesterol: a critical determinant of cellular energetics and tubular resistance to attack. Kidney Int 2000; 58(1): 193-205.
26. Dong J, Yang H, Zhang Y, Chen L, Hu Q. A high triglyceride glucose index is associated with early renal impairment in the hypertensive patients. Front Endocrinol 2022; 13: 1038758.
27. Dong J, Yang H, Zhang Y, Hu Q. Triglyceride-glucose index is a predictive index of hyperuricemia events in elderly patients with hypertension: a cross-sectional study. Clin Exp Hypertens 2022; 44(1): 34-9.
Copyright (c) 2023 Zihan Jin, Lu Xiao, Xinyi Xu, Changhong Miao, Yi Liu
This work is licensed under a Creative Commons Attribution 4.0 International License.
The published articles will be distributed under the Creative Commons Attribution 4.0 International License (CC BY). It is allowed to copy and redistribute the material in any medium or format, and remix, transform, and build upon it for any purpose, even commercially, as long as appropriate credit is given to the original author(s), a link to the license is provided and it is indicated if changes were made. Users are required to provide full bibliographic description of the original publication (authors, article title, journal title, volume, issue, pages), as well as its DOI code. In electronic publishing, users are also required to link the content with both the original article published in Journal of Medical Biochemistry and the licence used.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.