Roles of MIR155HG and TNF-α in Evaluation of Prognosis of Patients with Systemic Lupus Erythematosus
Associations of MIR155HG and TNF-α with Systemic Lupus Erythematosus
Abstract
Background: To study the roles of micro ribonucleic acid (miR)-155 host gene (MIR155HG) and tumor necrosis factor-α (TNF-α) in the evaluation of prognosis of patients with systemic lupus erythematosus (SLE).
Methods: A total of 130 patients with SLE admitted to our hospital were selected, and the SLE disease activity index (SLEDAI) score was given. The expressions of MIR155HG and TNF-α were detected via quantitative reverse transcription-polymerase chain reaction (qRT-PCR), the incidence of complications during treatment was observed, and the associations of MIR155HG and TNF-α with SLEDAI before treatment and complications were analyzed. All patients were followed up after discharge, and the related factors to the prognosis of patients were analyzed via Cox regression analysis.
Results: The levels of MIR155HG and TNF-α were higher in patients with an SLEDAI score of 10-14 points than those in patients with an SLEDAI score of 5-9 points and 0-4 points. MIR155HG and TNF-α were positively correlated with the incidence of infection, renal damage and cardiac damage. Moreover, there was also a positive correlation between the expressions of serum MIR155HG and TNF-α in SLE patients. SLEDAI score ≥10 points, complications during hospitalization, and highly-expressed MIR155HG and TNF-α were risk factors related to the prognosis of patients.
Conclusion: MIR155HG and TNF-α are key regulators in the pathogenesis of SLE, and they can affect the prognosis of patients. Such a finding provides potential new targets for the treatment of SLE.
References
1. Tsokos GC. Systemic lupus erythematosus. New Engl J Med 2011; 365(22): 2110-21.
2. Figueiredo-Braga M, Cornaby C, Cortez A, Bernardes M, Terroso G, Figueiredo M, et al. Depression and anxiety in systemic lupus erythematosus: The crosstalk between immunological, clinical, and psychosocial factors. Medicine 2018; 97(28): e11376.
3. Sigdel KR, Cheng A, Wang Y, Duan L, Zhang Y. The Emerging Functions of Long Noncoding RNA in Immune Cells: Autoimmune Diseases. J Immunol Res 2015; 2015(848790.
4. Balasubramaniyan V, Bhat KP. Targeting MIR155HG in glioma: a novel approach. Neuro-Oncology
5. Baytak E, Gong Q, Akman B, Yuan H, Chan WC, Kucuk C. Whole transcriptome analysis reveals dysregulated oncogenic lncRNAs in natural killer/T-cell lymphoma and establishes MIR155HG as a target of PRDM1. Tumour Biol 2017; 39(5): 1393388016.
6. Morman RE, Schweickert PG, Konieczny SF, Taparowsky EJ. BATF regulates the expression of Nfil3, Wnt10a and miR155hg for efficient induction of antibody class switch recombination in mice. Eur J Immunol 2018; 48(9): 1492-505.
7. Khoshmirsafa M, Kianmehr N, Falak R, Mowla SJ, Seif F, Mirzaei B, et al. Elevated expression of miR-21 and miR-155 in peripheral blood mononuclear cells as potential biomarkers for lupus nephritis. Int J Rheum Dis 2019; 22(3): 458-67.
8. Kollias G, Kontoyiannis D, Douni E, Kassiotis G. The role of TNF/TNFR in organ-specific and systemic autoimmunity: implications for the design of optimized 'anti-TNF' therapies. Curr Dir Autoimmun 2002; 5(30-50.
9. Mageed RA, Isenberg DA. Tumour necrosis factor alpha in systemic lupus erythematosus and anti-DNA autoantibody production. Lupus 2002; 11(12): 850-5.
10. Wu H, Liu J, Li W, Liu G, Li Z. LncRNA-HOTAIR promotes TNF-alpha production in cardiomyocytes of LPS-induced sepsis mice by activating NF-kappaB pathway. Biochem Bioph Res Co 2016; 471(1): 240-6.
11. Kong J, Li L, Lu Z, Song J, Yan J, Yang J, et al. MicroRNA-155 Suppresses Mesangial Cell Proliferation and TGF-beta1 Production via Inhibiting CXCR5-ERK Signaling Pathway in Lupus Nephritis. Inflammation 2019; 42(1): 255-63.
12. Petri M, Orbai AM, Alarcon GS, Gordon C, Merrill JT, Fortin PR, et al. Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum 2012; 64(8): 2677-86.
13. Mastorodemos V, Mamoulaki M, Kritikos H, Plaitakis A, Boumpas DT. Central nervous system involvement as the presenting manifestation of autoimmune rheumatic diseases: an observational study using the American College of Rheumatology nomenclature for neuropsychiatric lupus. Clin Exp Rheumatol 2006; 24(6): 629-35.
14. Gonzalez LA, Munoz C, Restrepo M, Vanegas AL, Vasquez G. Tuberculosis infection causing intestinal perforations in 2 patients with systemic lupus erythematosus. Jcr-J Clin Rheumatol 2014; 20(5): 287-90.
15. Nasonov E, Soloviev S, Davidson JE, Lila A, Togizbayev G, Ivanova R, et al. Systemic lupus erythematosus and associated healthcare resource consumption in selected cities from the Russian Federation, Republic of Kazakhstan and Ukraine: the ESSENCE study. J Med Econ 2018; 21(10): 1006-15.
16. Sahebari M, Rezaieyazdi Z, Khodashahi M, Abbasi B, Ayatollahi F. Brain Single Photon Emission Computed Tomography Scan (SPECT) and functional MRI in Systemic Lupus Erythematosus Patients with Cognitive Dysfunction: A Systematic Review. Asia Ocean J Nucl Med Biol 2018; 6(2): 97-107.
17. Rodriguez BR, Ortega GA, Hidalgo MA, Zentella DA, Villarreal-Garza C, Avila-Moreno F, et al. Long non-coding RNAs: implications in targeted diagnoses, prognosis, and improved therapeutic strategies in human non- and triple-negative breast cancer. Clin Epigenetics 2018; 10(88.
18. Wang Y, Chen S, Chen S, Du J, Lin J, Qin H, et al. Long noncoding RNA expression profile and association with SLEDAI score in monocyte-derived dendritic cells from patients with systematic lupus erythematosus. Arthritis Res Ther 2018; 20(1): 138.
19. Xu Y, Deng W, Zhang W. RETRACTED: Long non-coding RNA TUG1 protects renal tubular epithelial cells against injury induced by lipopolysaccharide via regulating microRNA-223. Biomed Pharmacother 2018; 104(509-19.
20. Wu X, Wang Y, Yu T, Nie E, Hu Q, Wu W, et al. Blocking MIR155HG/miR-155 axis inhibits mesenchymal transition in glioma. Neuro-Oncology 2017; 19(9): 1195-205.
21. Wang G, Tam LS, Kwan BC, Li EK, Chow KM, Luk CC, et al. Expression of miR-146a and miR-155 in the urinary sediment of systemic lupus erythematosus. Clin Rheumatol 2012; 31(3): 435-40.
22. Suarez A, Lopez P, Mozo L, Gutierrez C. Differential effect of IL10 and TNFalpha genotypes on determining susceptibility to discoid and systemic lupus erythematosus. Ann Rheum Dis 2005; 64(11): 1605-10.
23. Aringer M, Graninger WB, Steiner G, Smolen JS. Safety and efficacy of tumor necrosis factor alpha blockade in systemic lupus erythematosus: an open-label study. Arthritis Rheum 2004; 50(10): 3161-9.
24. Dogra S, Khullar G. Tumor necrosis factor-alpha antagonists: Side effects and their management. Indian J Dermatol Ve 2013; 79 Suppl 7(S35-46.
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