- Correlation between 25-hydroxyvitamin D Level of Lactating Mothers and Bone Mineral Density of Infants and Analysis of Risk Factors
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Abstract
Abstract: it was to demonstrate the influencing factors of infant bone mineral density(BMD) and its correlation with serum 25-hydroxyvitamin D (25-(OH)D) in nursing mothers. 200 children aged 0 ~ 1 years were rolled into normal group (n=120) and abnormal group (n=80) regarding the results of ultrasound BMD examination. The sunshine duration of infants with different BMD and 25-(OH)D, calcium and phosphorus levels of nursing mothers were analyzed, and univariate and multivariate analyses of BMD were implemented. The results revealed that the sunshine duration and serum 25-(OH)D level of nursing mothers in abnormal group were inferior to those in normal group (P<0.05). Additionally, a notable positive correlation existedbetween sunshine duration, serum 25-(OH)D level of nursing mothers and BMD (r = 0.911 and 0.503, P<0.05). According to Logistic regression analysis, outdoor activity time 0 ~ 1 h/d, premature infants, and breastfeeding alone were independent risk factors (RFs) for abnormal BMD in infants, and vitamin D(VD) and calcium supplementation were independent protective factors (P<0.05). VD and calcium intake, adequate sunshine duration, mixed feeding, and increasing serum 25-(OH)D can reduce the occurrence of abnormal BMD in infants.
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